Diet fat saturation and feeding state modulate rates of cholesterol synthesis in normolipidemic men

Journal of Nutrition

Volumn 127, Issue 2, 1997, Pages 332-340

  Mazier, M J Patricia ^a,b   Jones, Peter J H ^a,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ST FRANCIS XAVIER UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

cholesterol synthesis; dietary fat; humans

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; CALCULATION; CATABOLISM; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; DIAGNOSTIC ACCURACY; DIETARY INTAKE; FAT INTAKE; FEEDING BEHAVIOR; HUMAN; HUMAN EXPERIMENT; HYPERLIPIDEMIA; LIPID BLOOD LEVEL; MALE; NORMAL HUMAN; PROTEIN METABOLISM;

EID: 0031049286     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/127.2.332     Document Type: Article

References (38)

1. Allain, C. C., Poon, L., Chan, S. G., Richmond, W. & Fu, P. (1974) Enzymatic determination of total serum cholesterol. Clin. Chem. 20: 470-475.
2. Bannon, C. D., Craske, J. D., Har, N. T., Harper, N. L. & O'Rourke, K. L. (1982) Analysis of fatty acid methyl esters with high accuracy and reliability. II. Methylation of fats and oils with boron triflouride-methanol. J. Chromatogr. 247: 63-69.
3. Bell, L., Jones, P.J.H., Telch, J., Clandinin, M. T. & Pencharz, P. B. (1985) Prediction of energy needs for clinical studies. Nutr. Res. 5: 123-129.
4. Bucolo, G. & David, H. (1973) Quantitative determination of serum triglycerides by the use of enzymes. Clin. Chem. 19: 476-482.
5. Connor, W. E., Witiak, D. T., Stone, D. B. & Armstrong, M. L. (1969) Cholesterol balance and fecal neutral steroid and bile acid excretion in normal men fed dietary fats of different fatty acid composition. J. Clin. Invest. 48: 1363-1375.
6. Dell, R. B., Mott, G. E., Jackson, E. M., Ramakrishnan, R., Carey, K. D., McGill, H. C. & Goodman, D. S. (1985) Whole body and tissue cholesterol turnover in the baboon. J. Lipid Res. 26: 327-337.
7. Dietschy, J. M. & Spady, D. K. (1984) Measurement of rates of cholesterol synthesis using tritiated water. J. Lipid. Res. 25: 1469-1476.
8. Fernandez, M. L. & McNamara, D. J. (1994) Dietary fat saturation and chain length modulate guinea pig hepatic cholesterol metabolism. J. Nutr. 124: 331-339.
9. Folch, J., Lees, M. & Sloane Stanley, G. H. (1957) A simple method for the extraction and purification of total lipides from animal tissues. J. Biol. Chem. 226: 497-509.
10. Foster, D. M., Barrett, P.H.R., Toffolo, G., Beltz, W. F. & Cobelli, C. (1993) Estimating the fractional synthetic rate of plasma apolipoproteins and lipids from stable isotope data. J. Lipid Res. 34: 2193-2205.
11. Foster, D. M. & Boston, R. C. (1983) The use of compartmental analysis: the SAAM and CONSAM programs. In: Compartmental Distribution of Radiotraers (Robertson, J. S., ed.), pp. 73-142. CRC Press, Boca Raton, FL.
12. Goodman, D. S., Noble, R. P. & Dell, R. B. (1973) Three-pool model of the long-term turnover of plasma cholesterol in man. J. Lipid Res. 14: 178-188.
13. Grundy, S. M. & Ahrens, E. H., Jr. (1969) Measurements of cholesterol turnover, synthesis, and absorption in man, carried out by isotope kinetic and sterol balance techniques. J. Lipid Res. 10: 91-107.
14. Grundy, S. M. & Ahrens, E. H., Jr. (1970) The effects of unsaturated dietary fats on absorption, excretion, synthesis, and distribution of chelesterol in man. J. Clin. Invest. 49: 1135-1152.
15. Health and Welfare Canada (1988) Canadian Nutrient File. Canadian Government Printing Centre, Ottawa, Canada.
16. Jones, P.J.H., Leitch, C. A., Li, Z. C. & Connor, W. E. (1993) Hman cholesterol synthesis measurement using deuterated water. Theoretical and procedural consideartions. Arterioschler. Thromb. 13: 247-253.
17. Jones, P.J.H., Lichtenstein, A. H. & Schaefer, E. J. (1994a) Interaction of dietary fat saturation and cholesterol level on cholesterol synthesis measured using deuterium incorporation. J. Lipid Res. 35: 1093-1101.
18. Jones, P.J.H., Lichtenstein, A. H., Schaefer, E. J., & Namchuk, G. L. (1994b) Effect of dietary fat selection on plasma cholesterol synthesis in older, moderately hypercholesterolemic humans. Arterioschler. Thromb. 14: 542-548.
19. Jones, P.J.H., Pappu, A. S., Illingworth, D. R. & Leitch, C. A. (1992) Correspondence between plasma mevalonic acid levels and deuterium uptake in measuring human cholesterol synthesis. Eur. J. Clin. Invest. 22: 609-613.
20. Jones, P.J.H., Scanu, A. M. & Schoeller, D. A. (1988) Plasman cholesterol synthesis using deuterated water in humans: effect of short-term food restriction. J. Lab. Clin. Med. 111: 627-633.
21. Jones, P.J.H. & Schoeller, D. A. (1990) Evidence for diurnal periodicity in human cholesterol synthesis. J. Lipid Res. 31: 667-673.
22. Kushner, R. F. & Schoeller, D. A. (1986) Estimation of total body water by bioelectrical impedance analysis. Am. J. Clin. Nutr. 44: 417-424.
23. Mattson, F. H. & Grundy, S. M. (1985) Comparison of effects of dietrary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoporoteins in man. J. Lipid Res. 26: 194-202.
24. Marquardt, D. W. (1963) An algorithm for least-squares estimation of nonlinear parameters. J. Soc. Indust. Appl. Math. 11: 431-441.
25. Mazier, M.J.P. & Jones, P.J.H. (1991) Dietary fat quality and circulating cholesterol levels in humans: a review of actions and mechanisms. Prog. Food Nutr. Sci. 15: 21-41.
26. McNamara, D. J., Kolb, R., Parker, T. S., Batwin, H., Samuel, P., Brown, C. D. & Ahrens, E. H., Jr. (1987) Heterogeneity of cholesterol homeostasis in man: responses to changes in dietary fat quality and cholesterol quantity. J. Clin. Invest. 79: 1729-1739.
27. Mensink, R. P. (1994) Dietary monounsaturated fatty acids and serum lipoprotein levels in healthy subjects. Atherosclerosis 110: S65-S68.
28. Mifflin, M. D., St. Jeor, S. T., Hill, L. A., Scott, B. J., Daugherty, S. A. & Koh, Y. O. (1990) A new predictive equation for tresting energy expenditure in healthy individuals. Am. J. Clin. Nutr. 51: 241-247.
29. Nestel, P. J., Havenstein, N., Whyte, H. M., Scott, T. J. Cool, L. J. (1973) Lowering of plasma cholesterol and enhancement sterol excretion with the consumption of polyunsaturated ruminant fats. N. Engl. J. Med. 288: 379-382.
30. Oh, S. Y. & Monaco, P. A. (1985) Effect of dietary cholesterol and degree of fat unsaturation on plasma lipid levels, lipoprotein composition, and fecal steroid excretion in normal young adult men. Am. J. Clin. Nutr. 42: 399-413.
31. Schwartz, C. C., Zech, L. A., VanderBroek, J. M. & Cooper, P. A. (1993) Cholesterol kinetics in subjects with bile fistula. Positive relationship between size of the bile acid precursor pool and bile acid synthesis rate. J. Clin. Invest. 91: 923-938.
32. Shepherd, J., Packard, C. J., Grundy, S. M., Yeshurun, D., Gotto, A. M., Jr. & Taunton, O. D. (1980) Effects of saturated and polyunsaturated after diets on the chemical composition and metabolism of low density lipoproteins in man. J. Lipid Res. 21: 91-99.
33. Spady, D. K. & Dietschy, J. M. (1983) Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster, and rat. J. Lipid Res. 24: 303-315.
34. Spritz, N., Ahrens, E. H., Jr. & Grundy, S. M. (1965) Sterol balance in man as plasma cholesterol concentrations are altered by exchanges of dietary fat. J. Clin. Invest. 44: 1482-1493.
35. Stahler, F., Gruber, W., Stinshoff, K. & Roschlau, P. (1977) A reliable enzymatic assay for cholesterol determination. Med. Lab. 30: 29-37.
36. Turley, S. D., Spady, D. K. & Dietschy, J. M. (1995) Role of liver in the synthesis of cholesterol and the clearance of low density lipoproteins in the cynomolgus monkey. J. Lipid Res. 36: 67-79.
37. Warnick, G. R., Nguyen, T. & Albers, A. (1985) Comparison of improved precipitiation methods for quantification of high-density lipoprotein cholesterol. Clin. Chem. 31: 217-222.
38. Zar, J. H. (1974) Biostatistical Analysis. Prentice-Hall, Englewood Cliffs, NJ.