Design of artificial transcriptional activators with rigid poly-L-proline linkers

Journal of the American Chemical Society

Volumn 124, Issue 44, 2002, Pages 13067-13071

  Arora, Paramjit S ^a   Ansari, Aseem Z ^b,c   Best, Timothy P ^a   Ptashne, Mark ^b   Dervan, Peter B ^a  

^a California Institute of Technology   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION ACTIVATION;

DNA;

POLYAMIDES;

DNA; PEPTIDE; POLYAMIDE; PROLINE DERIVATIVE; SYNTHETIC PEPTIDE; TRANSCRIPTION FACTOR;

ARTICLE; CHEMICAL STRUCTURE; DNA BINDING; EUKARYOTE; PROTEIN DOMAIN; TRANSCRIPTION INITIATION;

AMINO ACID SEQUENCE; BASE SEQUENCE; BIOMIMETIC MATERIALS; CROSS-LINKING REAGENTS; DNA-BINDING PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0037032308     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0208355     Document Type: Article

References (16)

1. Ptashne, M.; Gann, A. Nature 1997, 386, 569-577.
2. Ptashne, M.; Gann, A. Genes and Signals; Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, 2001.
3. Mapp, A. K.; Ansari, A. Z.; Ptashne, M.; Dervan, P. B. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 3930-3935.
4. Ansari, A. Z.; Mapp, A. K.; Nguyen, D.; Dervan, P. B.; Ptashne, M. Chem. Biol. 2001, 8, 583-592.
5. Stryer, L.; Haugland, R. P. Biochemistry 1967, 6, 719-726.
6. Baird, E. E.; Dervan, P. B. J. Am. Chem. Soc. 1996, 118, 6141-6146.
7. Mapp, A. K.; Dervan, P. B. Tetrahedron Lett. 2000, 41, 9451-9454.
8. Senear, D. F.; Brenowitz, M.; Shea, M. A.; Ackers, G. K. Biochemistry 1986, 25, 7344-7354.
9. Brenowitz, M.; Senear, D. F.; Shea, M. A.; Ackers. G. K. Methods Enzymol. 1986, 130, 132-181.
10. Haugland, R. P. Hondbook of Fluorescent Probes and Research Chemicals; 6th Ed.: Molecular Probes Inc.: Eugene. OR, 1996.
11. Kim, T. K.; Roeder, R. G. J. Biol. Chem. 1993, 268, 20866-20869.
12. Gill, G.; Ptashne, M. Nature 1988, 334, 721-724.
13. (a) Kuznetsova, S.; Ait-Si-Ali, S.; Nagibneva, I.; Troalan, F.; Le Villain, J.-P.; Harel-Bellan, A.; Svinarchuk, F. Nucleic Acids Res. 1999. 27,3995-4000.
14. (b) Stanojevic, D.; Young, R. A. Biochemistry 2002, 7209-7216.
15. (a) Denison, C.; Kodadek, T. Chem. Biol. 1998, 5, 129-145.
16. (b) Liu B.; Han, Y.; Corey, D. R.; Kodadek, T. J. Am. Chem. Soc. 2002, 124, 1838-1839.