Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria

Biochemistry

Volumn 37, Issue 20, 1998, Pages 7103-7112

  Bussiere, Dirksen E ^a   Muchmore, Steven W ^a   Dealwis, Christopher G ^a,b   Schluckebier, Gerd ^a   Nienaber, Vicki L ^a   Edalji, Rohinton P ^a   Walter, Karl A ^a   Ladror, Uri S ^a   Holzman, Thomas F ^a   Abad Zapatero, Cele ^a  

^a ABBOTT LABORATORIES   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLTRANSFERASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS SUBTILIS; CRYSTAL STRUCTURE; DNA BINDING; ENZYME CONFORMATION; ENZYME STRUCTURE; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN RNA BINDING; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BASE SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MICROBIAL; MACROLIDES; METHYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RNA, RIBOSOMAL; S-ADENOSYLHOMOCYSTEINE; VIRGINIAMYCIN;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS);

EID: 0032546573     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi973113c     Document Type: Article

References (55)

1. Weisblum, B. (1995) Antimicrob. Agents Chemother. 39, 577-585.
2. Westh, H., Hougaard, D. M., Vuust, J., and Rosdahl, V. T. (1995) Antimicrob. Agents Chemother. 39, 369-373.
3. Shivakumar, A. G., and Dubnau, D. (1981) Nucleic Acids Res. 9, 2549-2562.
4. Iordanescu, S. (1976) Arch. Roum. Pathol. Exp. Microbiol. 35, 111-118.
5. Monod, M., Denoya, C., and Dubnau, D. (1986) J. Bacteriol. 167, 138-147.
6. Su, S. L., and Dubnau, D. (1990) Biochemistry 29, 6033-6042.
7. Zhong, P., Pratt, S. D., Edalji, R. P., Walter, K. A., Holzman, T. F., Shivakumar, A. G., and Katz, L. (1995) J. Bacteriol. 177, 4327-4332.
8. Denoya, C. D., and Dubnau, D. (1987) J. Bacteriol. 169, 3857-3860.
9. Denoya, C. D., and Dubnau, D. (1989) J. Biol. Chem. 264, 2615-2624.
10. Skinner, R., Cundliffe, E., and Schmidt, F. J. (1983) J. Biol. Chem. 258, 12702-12706.
11. Cheng, X., Kumar, S., Posfai, J., Pflugrath, J. W., and Roberts, R. (1993) Cell 74, 299-307.
12. Klimasauskas, S. K., Roberts, R. J., and Cheng, X. (1994) Cell 76, 357-369.
13. O'Gara, M., Klimasauskas, S., Roberts, R. J., and Cheng, X. (1996) J. Mol. Biol. 261, 634-645.
14. O'Gara, M., Roberts, R. J., and Cheng, X. (1996) J. Mol. Biol. 263, 597-606.
15. Reinisch, K. M., Chen, L., Verdine, G. L., and Lipscomb, W. N. (1995) Cell 82, 143-153.
16. Schluckebier, G., Kozak, M., Bleimling, N., Weinhold, E., and Saenger, W. (1997) J. Mol. Biol. 265, 56-67.
17. Gong, W., O'Gara, M., Blumenthal, M., and Cheng, X. (1997) Nucleic Acids Res. 25, 2702-2715.
18. Wilson, G. G., and Murray, N. E. (1991) Annu. Rev. Genet. 25, 585-627.
19. Hodel, A. E., Gershon, P. D., Shi, X., and Quiocho, F. A. (1996) Cell 85, 247-256.
20. Vidgren, J., Svensson, L. A., and Liljas, A. (1994) Nature 368, 354-357.
21. Fu, Z., Hu, Y., Konishi, K., Takata, Y., Ogawa, H., Gomi, T., Fujioka, M., and Takusagawa, F. (1996) Biochemistry 35, 11985-11993.
22. Djordjevic, S., and Stock, A. M. (1997) Structure 5, 545-558.
23. Cheng, X. (1995) Annu. Rev. Biophys. Biomol. Struct. 24, 293-318.
24. Yu, L., Petros, A. M., Schnuchel, A., Zhong, P., Severin, J. M., Walter, K., Holzman, T. F., and Fesik, S. W. (1997) Nat. Struct. Biol. 4, 483-489.
25. Bussiere, D. E., Bastia, D., and White, S. W. (1995) Cell 80, 651-660.
26. Hendrickson, W. A. (1991) Science 254, 51-58.
27. Strauss, M. G., Westbrook, E. M., Naday, I., Coleman, T. A., Westbrook, M. L., Travis, D. J., Sweet, R. M., Pflugrath, J. W., and Stanton, M. (1990) Nucl. Instrum. Methods Phys. Res., Sect. A 297, 275-295.
28. Messerchmidt, A., and Pflugrath, J. W. (1987) J. Appl. Crystallogr. 20, 306-315.
29. Kabsch, W. (1988) J. Appl. Crystallogr. 21, 916-924.
30. Tate, M. W., Eikenberry, E. F., Barna, M. E., Wall, J. L., Lowrance, J. L., and Grunner, S. M. (1995) J. Appl. Crystallogr. 28, 196-205.
31. Gewirth, D. (1996) The HKL Manual, 5th ed., Yale University Press, New Haven, CT.
32. CCP4 (1994) Acta Crystallogr. D50, 760-763.
33. Furey, W., and Swaminathan, S. (1998) Methods Enzymol. 277 (in press).
34. La Fortelle, E. d., and Bricogne, G. (1997) Methods Enzymol. 276, 472-494.
35. Abrahams, J. P., and Leslie, A. G. W. (1996) Acta Crystallogr. D52, 30-42.
36. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1991) Acta Crystallogr. A47, 110-119.
37. Biosym, Inc. (1994) Quanta Manual.
38. Brünger, A. T., Kuriyan, J., and Karplus, M. (1987) Science 235, 458-460.
39. Brünger, A. T. (1992) Nature 355, 472-474.
40. Bernstein, F. C., Koetzle, T. P., Williams, G. J. B., Meyer, E. F., Brice, M. D., Rodgers, J. R., Kennard, O., and Shimanouchi, T. (1977) J. Mol. Biol. 112, 532-543.
41. Alexandrov, N. N. (1996) Protein Eng. 9, 727-732.
42. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291.
43. Burd, C., and Dreyfuss, G. (1994) Science 265, 615-620.
44. Nagai, K. (1996) Curr. Opin. Struct. Biol. 6, 53-61.
45. Xing, Y., GuhaThakurta, D., and Draper, D. E. (1997) Nat. Struct. Biol. 4, 24-27.
46. Brünger, A. T. (1997) Nat. Struct. Biol. 4 (Suppl.), 862-865.
47. Wilson, G. G. (1992) Methods Enzymol. 216, 259-279.
48. Posfai, J., Bhagwat, A. S., Posfai, G., and Roberts, R. J. (1989) Nucleic Acids Res. 17, 2421-2435.
49. Malone, T., Blumenthal, R. M., and Cheng, X. (1995) J. Mol. Biol. 253, 618-632.
50. Schluckebier, G., Labahn, J., Granzin, J., and Saenger, W. (1998) Biol. Chem. (in press).
51. Schluckebier, G., O'Gara, M., Saenger, W., and Cheng, X. (1995) J. Mol. Biol. 247, 16-20.
52. Noller, H. F. (1984) Annu. Rev. Biochem. 53, 119-162.
53. Carson, M. (1987) J. Mol. Graphics 5, 103-106.
54. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
55. Nicholls, A. J., Sharp, K. A., and Honing, B. (1991) Proteins: Struct., Fund., Genet. 11, 281-296.