Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis

Journal of Medicinal Chemistry

Volumn 42, Issue 19, 1999, Pages 3852-3859

  Hajduk, Philip J ^b   Dinges, Jürgen ^b   Schkeryantz, Jeffrey M ^b   Janowick, David ^b   Kaminski, Michele ^b   Tufano, Michael ^b   Augeri, David J ^b   Petros, Andrew ^b   Nienaber, Vicki ^b   Zhong, Ping ^b   Hammond, Rachel ^b   Coen, Michael ^b   Beutel, Bruce ^b   Katz, Leonard ^a,b   Fesik, Stephen W ^b  

^a KOSAN BIOSCIENCES INC   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LINCOSAMIDE; MACROLIDE; METHYLTRANSFERASE; METHYLTRANSFERASE INHIBITOR; MIKAMYCIN B; RIBOSOME RNA; TRANSFERASE INHIBITOR; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; ENZYME INHIBITOR INTERACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RNA METHYLATION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG RESISTANCE, MICROBIAL; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; METHYLTRANSFERASES; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN CONFORMATION; S-ADENOSYLMETHIONINE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 0033598415     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990293a     Document Type: Article

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