The 2.2 Å structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: Implications for the reaction mechanism

Journal of Molecular Biology

Volumn 289, Issue 2, 1999, Pages 277-291

  Schluckebier, Gerd ^a   Zhong, Ping ^a   Stewart, Kent D ^a   Kavanaugh, Tom J ^a   Abad Zapatero, Cele ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Antibiotic resistance; Methyltransferase; S adenosyl L methionine; Sinefungin; X ray structure

Indexed keywords

ADENINE; AMINO ACID; ENZYME INHIBITOR; HOMOCYSTEINE; MACROLIDE; METHYLTRANSFERASE; RIBOSOME RNA; RNA 23S; RNA METHYLTRANSFERASE; S ADENOSYLMETHIONINE; SINEFUNGIN; TRANSFERASE; ADENOSINE; ANTIFUNGAL AGENT; DRUG DERIVATIVE; LIGAND; RRNA (ADENOSINE O 2' )METHYLTRANSFERASE; RRNA (ADENOSINE-O-2'-)METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE;

ANTIBIOTIC RESISTANCE; ARTICLE; CHEMICAL STRUCTURE; COMPARATIVE STUDY; CONFORMATIONAL TRANSITION; CORRELATION FUNCTION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STRUCTURE; LIGAND BINDING; PRIORITY JOURNAL; AMINO ACID SEQUENCE; BACILLUS SUBTILIS; BINDING SITE; BIOSYNTHESIS; CHEMISTRY; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ADENOSINE; AMINO ACID SEQUENCE; ANTIBIOTICS, ANTIFUNGAL; BACILLUS SUBTILIS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MICROBIAL; LIGANDS; METHYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RNA, RIBOSOMAL, 23S; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE;

EID: 0033522646     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.2788     Document Type: Article

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