Physiological approaches to the prediction of drug-drug interactions in study populations

Current Drug Metabolism

Volumn 4, Issue 5, 2003, Pages 347-356

  Chien, J Y ^a   Mohutsky, M A ^a   Wrighton, S A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Drug drug interactions; Modeling; PBPK; Physiologically based pharmacokinetic modeling; Prediction; Simulation

Indexed keywords

CARBAMAZEPINE; CLARITHROMYCIN; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; DRUG METABOLITE; FLUCONAZOLE; ITRACONAZOLE; KETOCONAZOLE; LORNOXICAM; MIDAZOLAM; SIMVASTATIN; STIRIPENTOL; SULFAMETHOXAZOLE; SULFAPHENAZOLE; TERFENADINE; TOLBUTAMIDE; TRIAZOLAM; VERAPAMIL; WARFARIN;

ANALYTIC METHOD; AREA UNDER THE CURVE; BIOLOGICAL MODEL; CLINICAL STUDY; CORRELATION ANALYSIS; DOSE CALCULATION; DRUG BINDING; DRUG CLEARANCE; DRUG DISPOSITION; DRUG EXPOSURE; DRUG INFORMATION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG TISSUE LEVEL; EMPIRICISM; HUMAN; MATHEMATICAL COMPUTING; NONHUMAN; POPULATION RESEARCH; PREDICTION; PROBABILITY; PROSPECTIVE STUDY; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REVIEW; RISK ASSESSMENT; SIDE EFFECT; STOCHASTIC MODEL; VALIDATION PROCESS;

ANIMALS; COMPUTER SIMULATION; DRUG INTERACTIONS; HUMANS; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PHYSIOLOGY; POPULATION; PREDICTIVE VALUE OF TESTS; PROTEIN BINDING; REGIONAL BLOOD FLOW; RISK ASSESSMENT;

EID: 0142074687     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200033489307     Document Type: Review

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