Diarylurea Compounds Inhibit Caspase Activation by Preventing the Formation of the Active 700-Kilodalton Apoptosome Complex

Molecular and Cellular Biology

Volumn 23, Issue 21, 2003, Pages 7829-7837

  Lademann, Ulrik ^a   Cain, Kelvin ^c   Gyrd Hansen, Mads ^a   Brown, David ^c   Peters, Dan ^b   Jäättelä, Marja ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b NEUROSEARCH A S   (Denmark)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; APOPTOSIS INHIBITOR; APOPTOSOME; CASPASE; CASPASE 9; CASPASE INHIBITOR; CELL PROTEIN; CYTOCHROME C; HYBRID PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; INITIATOR CASPASE 9; MITOCHONDRIAL PROTEIN; PROTEIN BCL 2; PROTEIN INHIBITOR; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SERINE PROTEINASE OMI; TETRAPEPTIDE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; UREA DERIVATIVE;

APOPTOSIS; ARTICLE; CELL DEATH; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSOL; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; MITOCHONDRION; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASES; CELL LINE, TUMOR; CYTOCHROMES C; DEOXYADENINE NUCLEOTIDES; ENZYME ACTIVATION; ENZYME INHIBITORS; FAS LIGAND PROTEIN; HUMANS; MACROMOLECULAR SUBSTANCES; MEMBRANE GLYCOPROTEINS; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; UREA;

INTRACISTERNAL A-PARTICLES;

EID: 0142027846     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.21.7829-7837.2003     Document Type: Article

References (31)

1. Boldin, M. P., T. M. Goncharov, Y. V. Goltsev, and D. Wallach. 1996. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85:803-815.
2. Bratton, S. B., G. Walker, D. L. Roberts, K. Cain, and G. M. Cohen. 2001. Caspase-3 cleaves Apaf-1 into an approximately 30-kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1. 4 MDa apoptosome complex. Cell Death Differ. 8:425-433.
3. Cain, K., S. B. Bratton, C. Langlais, G. Walker, D. G. Brown, X. M. Sun, and G. M. Cohen. 2000. Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes. J. Biol. Chem. 275:6067-6070.
4. Cain, K., D. G. Brown, C. Langlais, and G. M. Cohen. 1999. Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex. J. Biol. Chem. 274:22686-22692.
5. Cecconi, F., G. Alvarez-Bolando, B. I. Meyer, K. A. Roth, and P. Gruss. 1998. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94:727-737.
6. Deng, Y., Y. Lin, and X. Wu. 2002. TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. Genes Dev. 16:33-45.
7. Ferri, K. R., and G. Kroemer. 2001. Organelle-specific initiation of cell death pathways. Nat. Cell Biol. 3:E255-E263.
8. Foghsgaard, L., D. Wissing, D. Mauch, U. Lademann, L. Bastholm, M. Boes, F. Elling, M. Leist, and M. Jäättelä. 2001. Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor. J. Cell Biol. 153:999-1009.
9. 2 in breast carcinoma cells. Oncogene 10:2297-2305.
10. Jäättelä, M., D. Wissing, K. Kokholm, T. Kallunki, and M. Egeblad. 1998. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J. 17:6124-6134.
11. Kaufmann, S. H., and M. O. Hengartner. 2001. Programmed cell death: alive and well in the new millennium. Trends Cell Biol. 11:526-534.
12. Kluck, R. M., E. Bossy-Wetzel, D. R. Green, and D. D. Newmeyer. 1997. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136.
13. Kuida, K., T. F. Haydar, C.-Y. Kuan, Y. Gu, C. Taya, H. Karasuyama, M. S.-S. Su, P. Rakic, and R. A. Flavell. 1998. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94:325-337.
14. Leist, M., and M. Jäättelä. 2001. Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell Biol. 2:589-598.
15. Li, H., H. Zhu, C.-J. Xu, and J. Yuan. 1998. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the fas pathway of apoptosis. Cell 94:491-501.
16. Li, P., D. Nijhawan, I. Budihardjo, S. M. Srinivasula, M. Ahmad, E. S. Alnemeri, and X. Wang. 1997. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates apoptotic protease cascade. Cell 91:479-489.
17. Lipinski, C. A., F. Lombardo, B. W. Dominy, and P. J. Feeney. 2001. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 46: 3-26.
18. Liu, X., C. N. Kim, J. Yang, R. Jemmerson, and X. Wang. 1996. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86:147-157.
19. Luo, X., I. Budihardjo, H. Zou, C. Slaughter, and X. Wang. 1998. Bid, a BclII interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481-490.
20. Mathiasen, I. S., and M. Jäättelä. 2002. Triggering caspase-independent cell death to combat cancer. Trends Mol. Med. 8:212-220.
21. Mathiasen, I. S., U. Lademann, and M. Jäättelä. 1999. Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53. Cancer Res. 59:4848-4856.
22. Mattson, M. P. 2000. Apoptosis in neurodegenerative disorders. Nat. Rev. Mol. Cell Biol. 1:120-129.
23. Muzio, M., A. M. Chinnaiyan, F. C. Kischkel, K. O'Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J. D. Bretz, M. Zhang, R. Gentz, M. Mann, P. H. Krammer, M. E. Peter, and V. M. Dixit. 1996. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85:817-827.
24. Pan, G., E. W. Humke, and V. M. Dixit. 1998. Activation of caspases triggered by cytochrome c in vitro. FEMS Lett. 426:151-154.
25. Reed, J. C. 2001. Apoptosis-regulating proteins as targets for drug discovery. Trends Mol. Med. 7:314-319.
26. Rensing-Ehl, A., K. Frei, R. Flury, B. Matiba, S. M. Mariani, M. Weller, P. Aebischer, P. H. Krammer, and A. Fontana. 1995. Local Fas/APO-1 (CD95) ligand-mediated tumor cell killing in vivo. Eur. J. Immunol. 25:2253-2258.
27. Scaffidi, C., S. Fulda, A. Srinivasan, C. Friesen, F. Li, K. J. Tomaselli, K. M. Debatin, P. H. Krammer, and M. E. Peter. 1998. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17:1675-1687.
28. Slee, E. A., M. T. Harte, R. M. Kluck, B. B. Wolf, C. A. Casiano, D. D. Newmeyer, H. G. Wang, J. C. Reed, D. W. Nicholson, E. S. Alnemri, D. R. Green, and S. J. Martin. 1999. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J. Cell Biol. 144:281-292.
29. Stennicke, H. R., J. M. Jurgensmeier, H. Shin, Q. Deveraux, B. B. Wolf, X. Yang, Q. Zhou, H. M. Ellerby, L. M. Ellerby, D. Bredesen, D. R. Green, J. C. Reed, C. J. Froelich, and G. S. Salvesen. 1998. Pro-caspase-3 is a major physiologic target of caspase-8. J. Biol. Chem. 273:27084-27090.
30. Strasser, A., L. O'Connor, and V. M. Dixit. 2000. Apoptosis signaling. Annu. Rev. Biochem. 69:217-245.
31. Thornberry, N. A., and Y. Lazebnik. 1998. Caspases: enemies within. Science 281:1312-1316.