Actions of leptin on growth hormone secretagogue-responsive neurones in the rat hypothalamic arcuate nucleus recorded in vitro

Journal of Neuroendocrinology

Volumn 13, Issue 2, 2001, Pages 209-215

  Tung, Y C L ^a   Hewson, A K ^a   Dickson, Suzanne L ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Feeding; Ghrelin; GHRP 6; Growth hormone releasing hormone; Neuropeptide Y

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; LEPTIN; NEUROPEPTIDE Y; PROTEIN FOS;

ANIMAL CELL; ARCUATE NUCLEUS; ARTICLE; CELL POPULATION; CONTROLLED STUDY; ELECTROSTIMULATION; GENE EXPRESSION; GROWTH HORMONE RELEASE; HYPOTHALAMUS; IN VITRO STUDY; MALE; NERVE CELL; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECORDING; SYNAPTIC TRANSMISSION;

ANIMALS; ARCUATE NUCLEUS; BODY WEIGHT; EATING; ELECTROPHYSIOLOGY; GROWTH HORMONE; INJECTIONS, INTRAVENTRICULAR; LEPTIN; MALE; NEURONS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR;

EID: 0035187884     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2001.00615.x     Document Type: Article

References (49)

1. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone
2. Growth hormone secretagogues: Physiological role and clinical utility
3. Systemic administration of growth hormone-releasing peptide (GHRP-6) activates hypothalamic arcuate neurones
4. Central actions of peptide and non-peptide growth hormone secretagogues in the rat
5. GHRP-6 induced changes in electrical activity of single cells in the arcuate, ventromedial and periventricular nucleus nuclei of a hypothalamic slice preparation in vitro
6. A pituitary gland and hypothalamic receptor that functions in growth hormone release
7. Ghrelin is a growth-hormone-releasing acylated peptide from stomach
8. Induction of Fos mRNA in neuropeptide Y and growth hormone-releasing hormone neurones in the rat arcuate nucleus following systemic injection of the growth hormone secretagogue, GHRP-6
9. Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurones in the mediobasal hypothalamus
10. Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat
11. Chronic administration of neuropeptide Y into the lateral ventricle inhibits both the pituitary-testicular axis and growth hormone and insulin-like growth factor I secretion in intact adult male rats
12. Neuropeptide Y injected in the paraventricular hypothalamus: A powerful stimulant of feeding behavior
13. Neuropeptide Y stimulates feeding but inhibits sexual behavior in rats
14. Intracerebroventricular growth-hormone-releasing peptide-6 stimulates eating without affecting plasma growth hormone responses in rats
15. Intracelebroventricular administration of the growth hormone-releasing peptide KP-102 increases food intake in free-feeding rats
16. Positional cloning of the mouse obese gene and its human homologue
17. A novel leptin receptor isoform in rat
18. Localization of leptin receptor mRNA expression in mouse brain
19. Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus-relationship with NPY neurones
20. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus
21. Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus
22. Leptin receptor immunoreactivity in chemically defined target neurones of the hypothalamus
23. Proopiomelanocortin neurones are direct targets for leptin in the hypothalamus
24. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
25. Effects of the obese gene product on body weight regulation in oblob mice
26. Weight-reducing effect of the plasma-protein encoded by the obese gene
27. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in oblob mice
28. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus
29. Regulation of in vivo growth hormone secretion by leptin
30. Role of growth hormone (GH)-releasing hormone and somatostatin on leptin-induced GH secretion
31. Phasically firing neurones in the supraoptic nucleus of the rat hypothalamus: Immunocytochemical and electrophysiological studies
32. The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system
33. The anatomy of neuropeptide-Y-containing neurones in rat brain
34. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus
35. Leptin inhibits hypothalamic neurones by activation of ATP-sensitive potassium channels
36. Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus
37. Leptin is a potent stimulator of spontaneous pulsatile growth hormone (GH) secretion and the GH response to GH-releasing hormone
38. An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide Y-containing system which lacks noradrenaline in the rat
39. Arcuate nucleus neurones that project to the hypothalamic paraventricular nucleus: Neuropeptidergic identity and consequences of adrenalectomy on mRNA levels in the rat
40. An electrophysiological and morphological investigation of the projections of growth hormone-releasing peptide-6-responsive neurones in the rat arcuate nucleus to the median eminence and to the paraventricular nucleus
41. Activation of the hypothalamo-pituitary-adrenal axis by the growth hormone (GH) secretagogue, GH-releasing peptide-6, in rats
42. Activation of arcuate nucleus neurones by systemic administration of leptin and growth hormone-releasing peptide-6 in normal and fasted rats
43. Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels
44. Induction of Fos expression in hypothalamic magnocellular neurones requires synaptic activation and not simply increased spike activity
45. Interactions between leptin and hypothalamic neuropeptide Y neurones in the control of food intake and energy homeostasis in the rat
46. Leptin regulates GH secretion in the rat by acting on GHRH and somatostatinergic functions
47. Central leptin infusion effects the expression of hypothalamic genes involved in growth hormone regulation
48. Chronic central infusion of growth hormone secretagogues: Effects on Fos expression and peptide gene expression in the rat arcuate nucleus