Prediction of normal tissue response and individualization of doses in radiotherapy

Physics in Medicine and Biology

Volumn 48, Issue 19, 2003, Pages 3213-3223

  Guirado, Damián ^a   Ruiz de Almodóvar, José Mariano ^a  

^a HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; DNA; DOSIMETRY; MONTE CARLO METHODS; TISSUE;

RADIOSENSITIVITY;

RADIOTHERAPY;

ARTICLE; BIOASSAY; CANCER CONTROL; CANCER RADIOTHERAPY; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; HEALTH PROGRAM; HUMAN; INDIVIDUALIZATION; MONTE CARLO METHOD; PATIENT MONITORING; PREDICTION; PRIORITY JOURNAL; PROBABILITY; QUANTITATIVE ANALYSIS; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIATION MONITORING; RADIOSENSITIVITY; RELIABILITY; SENSITIVITY ANALYSIS; TISSUE REACTION;

ADAPTATION, PHYSIOLOGICAL; CELL SURVIVAL; COMPUTER SIMULATION; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; MODELS, BIOLOGICAL; MODELS, STATISTICAL; NEOPLASMS; RADIATION TOLERANCE; RADIOMETRY; RADIOTHERAPY; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

EID: 0141894126     PISSN: 00319155     EISSN: None     Source Type: Journal    
DOI: 10.1088/0031-9155/48/19/008     Document Type: Article

References (32)

1. Barber J B, Burrill W, Spreadborough A R, Levine E, Warren C, Kiltie A E, Roberts S A and Scott D 2000 Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer Radiother. Oncol. 55 179-86
2. Begg A C, Russell N S, Knaken H and Lebesque J V 1993 Lack of correlation of human fibroblast radiosensitivity in vitro with early skin reactions in patients undergoing radiotherapy Int. J. Radiat. Biol. 64 393-405
3. Borgmann K, Röper B, El-Awady R A, Brackrock S, Bigalke M, Dörk T, Alberti W, Dikomey E and Dahm-Daphi J 2002 Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations Radiother. Oncol. 64 141-52
4. Brahme A 2001 Individualizing cancer treatment: biological optimization models in treatment planning and delivery Int. J. Radiat. Oncol. Biol. Phys. 49 327-37
5. Brammer I, Zoller M and Dikomey E 2001 Relationship between cellular radiosensitivity and DNA damage measured by comet assay in human normal NBS and AT fibroblast Int. J. Radiat. Biol. 77 929-38
6. Brock W A, Tucker S L, Geara F B, Turesson I, Wike J, Nyman J and Peters L J 1995 Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer Int. J. Radiat. Oncol. Biol. Phys. 32 1371-9
7. Carlomagno F, Burnet N G, Turesson I, Nyman J, Peacock J H, Dunning A M, Ponder B A and Jackson S P 2000 Comparison of DNA repair protein expression and activities between human fibroblast cell lines with different radiosensitivities Int. J. Cancer 85 845-9
8. Dickson J, Magee B, Stewart A and West C 2002 Relationship between residual radiation-induced Dna double-strand breaks in cultured fibroblasts and late radiation reactions: a comparison of training and validation cohorts of breast cancer patients Radiother. Oncol. 62 321-6
9. Dikomey E, Brammer I, Johansen J, Bentzen S M and Overgaard J 2000 Relationship between DNA double strand breaks, cell killing, and fibrosis studied in confluent skin fibroblast derived from breast cancer patients Int. J. Radiat. Oncol. Biol. Phys. 46 481-90
10. Jonhson N L, Kotz S and Balakrishnan N 1994 Continuous Univariate Distributions vol 1 2nd edn (New York: Wiley) p 337
11. Källman P, Ågren A and Brahme A 1992 Tumor and normal tissue responses to fractionated no-uniform dose-delivery Int. J. Radiat. Biol. 23 249-62
12. Kiltie A E, Ryan A J, Swindell R, Barber J B, West C M, Magee B and Hendry J H 1999 A correlation between residual radiation-induced DNA double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients Radiother. Oncol. 51 55-65
13. Koch A L 1966 The logarithm in biology 1. Mechanisms generating the lognormal distribution exactly J. Theoret. Biol. 12 276-90
14. Koch A L 1969 The logarithm in biology 2. Distribution simulating the lognormal J. Theoret. Biol. 23 251-68
15. Mackay R I and Hendry J H 1999 The modelled benefits of individualizing patients' dose using cellular radiosensitivity assays with inherent variability Radiother. Oncol. 50 67-75
16. Núñez M I, Guerrero R, López E, del Moral M R, Valenzuela M T, Siles E, Villalobos M, Pedraza V, Peacock J H and Ruiz de Almodóvar J M 1998 DNA damage and prediction of radiation response in lymphocytes and epidermal skin human cells Int. J. Cancer 76 354-61
17. Núñez M I, Mcmillan T J, Valenzuela M T, Ruiz de Almodóvar J M and Pedraza V 1996 Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells Radiother. Oncol. 39 155-65
18. Oppitz U, Schulte S, Stopper H, Baier K, Muller M, Wulf J, Schakowski R and Flentje M 2002 In vitro radiosensitivity measured in lymphocytes and fibroblasts by colony formation and comet assay: comparison with clinical acute reactions to radiotherapy in breast cancer patients Int. J. Radiat. Biol. 78 611-6
19. Ozsahin M, Ozsahin H, Yuquan S, Larsson B, Wügler F E and Crompton N E A 1997 Rapid assay of intrinsic radiosensitivity based on apoptosis in human CD4 and CD8 T-lymphocytes Int. J. Radiat. Oncol. Biol. Phys. 38 429-40
20. Peacock J, Ashton A, Bliss J, Bush C, Eady J, Jackson C, Owen R, Regan J and Yarnold J 2000 Cellular radiosensitivity and complication risk after curative radiotherapy Radiother. Oncol. 55 173-8
21. Powell S N, Mills J and Mcmillan T J 1998 Radiosensitive human tumour cell lines show misrepair of DNA termini Br. J. Radiol. 71 1178-84
22. Ramsay J and Birrell G 1995 Normal tissue radiosensitivity in breast cancer patients Int. J. Radiat. Oncol. Biol. Phys. 31 339-44
23. Ruiz de Almodóvar J M, Guirado D, Núñez M I, López E, Guerrero R, Valenzuela M T, Villalobos M and del Moral R 2002 Individualisation of radiotherapy in breast cancer patient: possible usefulness of a DNA damage assay to measure normal cell radiosensitivity Radiother. Oncol. 62 327-33
24. Ruiz de Almodóvar J M, Núñez M I, Mcmillan T J, Olea N, Mort C, Villalobos M, Pedraza V and Steel G G 1994a Initial radiation-induced DNA damage in human tumour cell lines: a correlation with intrinsic cellular radionsensitivity Br. J. Cancer 69 457-62
25. Ruiz de Almodóvar J M, Steel G G, Whitaker S J and Mcmillan T J 1994b A comparison of methods for calculating DNA double strand break induction frequency in mammalian cells by pulse field gel electrophoresis Int. J. Radial. Biol. 6 641-9
26. Safwat A, Bentzen S M, Turesson I and Hendry J H 2002 Deterministic rather than stochastic factors explain most of the variation in the expression of skin telangiectasia after radiotherapy Int. J. Radiat. Oncol. Biol. Phys. 52 198-204
27. Stausbøl-Grøn B, Bentzen S M, Jorgensen K E, Nielsen O S, Bundgaard T and Overgaard J 1999 In vitro radiosensitivity of tumour cells and fibroblasts derived from head and neck carcinomas: mutual relationship and correlation with clinical data Br. J. Cancer 79 1074-84
28. Tucker S L, Geara F B, Peters L J and Brock W A 1996 How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity? Radiother. Oncol. 38 103-13
29. Tucker S L, Turesson I and Thames H D 1992 Evidence for individual differences in the radiosensitivity of human skin Eur. J. Cancer 28A 1783-91
30. Turesson I, Nyman J, Holmberg E and Oden A 1996 Prognosis factor for acute and late skin reactions in radiotherapy patients Int. J. Radiat. Oncol. Biol. Phys. 36 1065-75
31. West C M, Davidson S E, Elyan S A, Swindell R, Roberts S A, Orton C J, Coyle C A, Valentine H, Wilks D P, Hunter R D and Hendry J H 1998 The intrinsic radiosensitivity of normal and tumor cells Int. J. Radiat. Biol. 73 409-13
32. West C M, Davidson S E, Elyan S A, Valentine H, Roberts S A, Swindell R and Hunter R D 2001 Lymphocyte radiosensitivity is a significant prognosis factor for morbidity in carcinoma of the cervix Int. J. Radiat. Oncol. Biol. Phys. 51 10-15