In vitro radiosensitivity of tumour cells and fibroblasts derived from head and neck carcinomas: Mutual relationship and correlation with clinical data

British Journal of Cancer

Volumn 79, Issue 7-8, 1999, Pages 1074-1084

  Stausbol Gron B ^a   Bentzen, S M ^b   Jorgensen K E ^b   Nielsen, O S ^b   Bundgaard, T ^b   Overgaard, J ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NONE

Author keywords

Differentiation; Fibroblasts; In vitro radiosensitivity; Predictive assays; Squamous cell carcinoma of the head and neck; Tumour cells

Indexed keywords

ADULT; AGED; ARTICLE; CANCER GRADING; FEMALE; FIBROBLAST; HEAD AND NECK CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIOSENSITIVITY; SQUAMOUS CELL CARCINOMA; TUMOR BIOPSY; TUMOR CELL; TUMOR DIFFERENTIATION;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CELL COUNT; FEMALE; FIBROBLASTS; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; LINEAR MODELS; MALE; MIDDLE AGED; RADIATION TOLERANCE; REPRODUCIBILITY OF RESULTS; TUMOR STEM CELL ASSAY;

EID: 0032983404     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690172     Document Type: Article

References (43)

1. Allalunis-Turner M, Pearcey RG, Barron GM, Buryn DA, Babiak JC and Honoré LH (1991) Inherent radiosensitivity testing of tumor biopsies obtained from patients with carcinoma of the cervix or endometrium. Radiother Oncol 22: 201-205
2. Allalunis-Turner M, Day R, Pearcey R and Urtasun R (1992) Radiosensitivity lesting in gynecological tumours and malignant gliomas. In Radiation Research: A Twentieth Century Perspective, Dewey W, Edington M, Fry R, Hall E and Whitmore G (eds), p. 712-715. Academic Press: San Diego
3. Azumi N and Battifora H (1987) The distribution of vimentin and keratin in epithelial and nonepithelial neoplasms. Am J Clin Pathol 88: 286-296
4. Beck-Bornholdt HP and Dubben HH (1994) Potential pitfalls in the use of P-values and in interpretation of significance levels. Radiother Oncol 33: 171-176
5. Bentzen SM (1997) Potential clinical impact of normal-tissue intrinsic radiosensitivity testing. Radiother Oncol 45: 121-131
6. Bentzen SM and Overgaard J (1994) Patient-to-patient variability in the expression of radiation-induced normal tissue injury. Semin Radiat Oncol 4: 68-80
7. Bernier J, Thames HD, Smith CD and Horiot JC (1998) Tumour response, mucosal reactions and late effects after conventional and hyperfractionated radiotherapy. Radiother Oncol 47: 137-143
8. Brock W, Baker FL and Peters LJ (1989) Radiosensitivity of human head and neck squamous cell carcinomas in primary culture and its potential as a predictive assay of tumor radiocurability. Int J Radiat Biol 56: 751-760
9. Brock W, Baker FL, Wike JL, Sivon SL and Peters LJ (1990) Cellular radiosensitivity of primary head and neck squamous cell carcinomas and local tumour control. Int J Radiat Oncol Biol Phys 18: 1283-1286
10. Broders A (1920) Squamous cell epithelioma of the lip. J Am Med Assoc 74: 656-664
11. Bujko K, Skoczylas JZ, Burzykowski T, Hliniak A and Chmielewska E (1994) Is radiosensitivity of laryngeal mucosa similar to radiosensitivity of its malignant derivative squamous cell supraglottic cancer? Radiother Oncol 32(suppl. 1): s87
12. Courtenay V (1984) A replenishable soft agar colony assay for human tumour sensitivity testing. Recent Results Cancer Res 94: 17-34
13. Courtenay V, Selby PJ, Smith IE, Mills J and Peckham MJ (1978) Growth of human tumour cell colonies from biopsies using two soft-agar techniques. Br J Cancer 38:77-81
14. Dahl O, Horn A and Mella O (1994) Do acute side-effects during radiotherapy predict tumour response in rectal carcinoma? Acta Oncol 33: 409
15. Dahlberg W, Little JB, Reicher JA, Suit HD and Okunieff P (1993) Radiosensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patients. Int J Radiat Biol 63: 191-198
16. Davidson SE, West CML, Roberts SA, Hendry JH and Hunter RD (1990) Radiosensitivity testing of primary cervical carcinoma: evaluation of intra-and inter-tumour heterogeneity. Radiother Oncol 18: 349-356
17. Deacon J, Peckham MJ and Steel GG (1984) The responsiveness of human tumours and the initial slope of the cell survival curve. Radiother Oncol 2: 317-323
18. Dische S, Saunders M, Barrett A, Harvey A, Gibson D and Parmar M (1997) A randomised multicentre trial of CHART vs conventional radiotherapy in head and neck cancer. Radiother Oncol 44: 123-136
19. Eschwege F, Bourhis J, Girinski T, Lartigau E, Guichard M, Deblé D, Kepta L, Wilson GD and Luboinski B (1997) Predictive assays of radiation response in patients with head and neck squamous cell carcinoma: a review of the Institute Gustave Roussy experience. Int J Radiat Biol Phys 39: 849-853
20. Fertil B and Malaise E (1981) Inherent cellular radiosensitivity as a basic concept for human tumour radiotherapy. Int J Radiat Oncol Biol Phys 7: 621-629
21. Fertil B and Malaise E (1985) Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumours: analysis of 101 published survival curves. Int J Radiat Oncol Biol Phys 11:1699-1707
22. Geara F, Peters LJ, Ang KK, Garden AS, Tucker SL, Levy LB and Brown BW (1996) Comparison between normal tissue reactions and local tumor control in head and neck cancer patients treated by definitive radiotherapy. Int J Radiat Oncol Biol Phys 35: 455-462
23. Girinski T and Fertil B (1993) Predictive value of in vitro radiosensitivity parameters in head and neck cancers and cervical carcinomas: preliminary correlations with local control and overall survival. Int J Radiat Oncol Biol Phys 25: 3-7
24. Girinski T, Bernheim A, Lubin R, Tavakoli-Razavi T, Baker F, Janot F, Wibault P, Cosset JM, Duvillard P, Duverger A and Fertil B (1994) In vitro parameters and treatment outcome in head and neck cancers treated with surgery and/or radiation: cell characterization and correlations with local control and overall survival. Int J Radiat Oncol Biol Phys 30: 789-794
25. Hansen O, Overgaard J, Hansen H, Overgaard M, Høyer M, Jørgensen KE, Bastholt L and Berthelsen A (1997) Importance of overall treatment time for the outcome of radiotherapy of advanced head and neck carcinoma: dependency on tumor differentiation. Radiother Oncol 43: 47-51
26. Haustermans K, Hofland I, Ramaekers M, Ivanyi D, Balm AJM, Geboes K, Lerut T, van der Schueren E and Begg AL (1996) Enrichment of tumor cells for cell kinetic analysis in human tumor biopsies using cytokeratin gating. Radiother Oncol 41: 237-248
27. Hermanek P and Sobin L (eds) (1987) UICC's TNM Classification of Malignant Tumours. Head and Neck Tumours, p. 13-29. Springer-Verlag: Berlin
28. Kocagöncü K, Marangoni G, Cozzi-Fogliata A, Griffin S, Garavaglia G, Thum P and Bernier J (1994) Intrinsic radiosensitivily of head and neck carcinomas as predictive test for clinical tumour control: comparative analysis and critical assessment of technical reliability. Radiat Oncol Invest 2: 177-184
29. Moll R, Franke WW, Schiller DL, Geiger B and Krepler R (1982) The catalog of human cytokeratins: patterns of expression in normal epithelia, tumours and cultured cells. Cell 31: 11-24
30. Nordsmark M, Overgaard M and Overgaard J (1996) Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 41: 31-39
31. Peters LJ, Brock WA, Chapman JD and Wilson G (1988) Predictive assays of tumour radiocurability. Am J Clin Oncol 11: 275-287
32. Schwartz J, Beckett M, Mustafi R, Vaughan A and Weichselbaum R (1992) Evaluation of different in vitro assays of inherent sensitivity as predictors of radiotherapy response. In: Radiation Research: A Twentieth Century Perspective, Dewey W, Edington M, Fry R, Hall E and Whitmore G (eds), p. 716-721. Academic Press: San Diego
33. Stausbøl-Grøn B. Nielsen OS, Bentzen SM and Overgaard J (1995) Selective assessment of in vitro radiosensitivity of tumour cells and fibroblasts from single tumour biopsies using immunocytochemical identification of colonies in the soft agar clonogenic assay. Radiother Oncol 37: 87-99
34. Stausbøl-Grøn B, Bentzen SM and Overgaard J (1996) Predictive assays in radiotherapy. The Aarhus experience. In vitro radiosensitivity in SCC of the head and neck. Radiother Oncol 40 (suppl. 1): s68
35. Stausbøl-Grøn B, Bentzen SM and Overgaard J (1998) Characterisation and radiosensitivity of fibroblasts derived from squamous cell carcinomas of the head and neck, and the surrounding mucosa. Acta Oncol 37; 697-700
36. Suo Z, Holm R and Nesland JM (1992) Squamous cell carcinomas, an immunohistochemical and ultrastructural study. Anticancer Res 12: 2025-2032
37. Taghian A, Suit H, Pardo F, Gioioso D, Tomkinson K, Dubois W and Gerweck L (1992) In vitro intrinsic radiation sensitivity of glioblastoma multiforme. Int J Radiat Oncol Biol Phys 23: 55-62
38. Tucker S, Turesson I and Thames HD (1992) Evidence for individual differences in the radiosensitivity of human skin. Eur J Cancer 28A: 1783-1791
39. West CML (1995) Intrinsic radiosensitivity as a predictor of patient response to radiotherapy. Br J Radiol 68: 827-837
40. West CML and Sutherland R (1986) A radiobiological comparison of human tumor soft-agar clonogenic assays. Int J Cancer 37: 897-903
41. West CML, Davidson SE and Hunter RD (1989) Evaluation of surviving fractional 2 Gy as a potential prognostic factor for the radiotherapy of carcinoma of the cervix. Int J Radiat Biol 56: 761-765
42. West CML, Davidson SE, Roberts SA and Hunter RD (1993) Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix. Br J Cancer 68: 819-823
43. West CML, Davidson SE, Roberts S and Hunter R (1997) The independence of intrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix. Br J Cancer 76: 1184-1190