The intrinsic radiosensitivity of normal and tumour cells

International Journal of Radiation Biology

Volumn 73, Issue 4, 1998, Pages 409-413

  West, C M L ^a   Davidson, S E ^b   Elyan, S A G ^a   Swindell, R ^b   Roberts, S A ^a   Orton, C J ^a   Coyle, C A ^b   Valentine, H ^a   Wilks, D P ^a   Hunter, R D ^b   Hendry, J H ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER RADIOTHERAPY; CLINICAL TRIAL; CLONOGENIC ASSAY; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; LYMPHOCYTE; MAJOR CLINICAL STUDY; MORBIDITY; PRIORITY JOURNAL; RADIOSENSITIVITY; SURVIVAL RATE; TUMOR CELL; UTERINE CERVIX CARCINOMA;

EID: 7144226576     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530098142248     Document Type: Conference Paper

References (31)

1. BENTZEN, S. M., 1997, Potential clinical impact of normal-tissue intrinsic radiosensitivity testing. Radiotherapy and Oncology, 43, 121-131.
2. BENTZEN, S. M., OVERGAARD, M. and OVERGAARD, J., 1993, Clinical correlations between late normal tissue endpoints alter radiotherapy: implications for predictive assays of radiosensitivity. European Journal of Cancer, 29A, 1373-1376.
3. BOURNE, R. G., KEARSLEY, J. H., GROVE, W. D. and ROBERTS, S. J., 1983, The relationship between early and late gastrointestinal complications of radiation therapy for carcinoma of the cervix. International Journal of Radiation Oncology, Biology, Physics, 9, 1445-1450.
4. BUDACH, W., HARTFORD, A. and GIOIOSO, D., 1992, Tumors arising in SCID mice share enhanced radiation sensitivity of SCID normal tissues. Cancer Research, 52, 6292-6296.
5. BURNET, N. G., WURM, R. and PEACOCK, J. H., 1996, Low dose rate fibroblast radiosensitivity and the prediction of patient response to radiotherapy. International Journal of Radiation Biology, 70, 289-300.
6. CHASSAGNE, D., SISMONDI, P., HORIOT, J. C., SINISTRERO, G., BEY, P., ZOLA, P., PERNOT, M., GERBAULET, A., KUNKLER, I. and MICHEL, G., 1993, A glossary for reporting complications of treatment in gynecological cancers. Radiotherapy and Oncology, 26, 195-202.
7. DAHL, O., HORN, A. and MELLA, O., 1994, Do acute side-effects during radiotherapy predict tumour response in rectal carcinoma? Acta Oncologica, 33, 400-413.
8. DAHLBERG, W. K., LITTLE, J. H., FLETCHER, J. A., SUIT, H. D. and OKUNIEFF, P., 1993, Radiosensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patients. International Journal of Radiation Biology, 63, 191-198.
9. DUNST, J. and GEBHART, D., 1995, Unexpected tumour response, radiation myelitis and increased in vitro radiosensitivity of lymphocytes in a patient with non-small cell lung cancer. Radiotherapy and Oncology, 36, 156-158.
10. EIFEL, P. J., LEVENBACK, C., WHARTON, J. T. and OSWALD, M. J., 1995, Time course and incidence of late complications in patients treated with radiation therapy for FIGO stage Ib carcinoma of the uterine cervix. International Journal of Radiation Oncology. Biology, Physics, 32, 1289-1300.
11. ELYAN, S. A. G., WEST, C. M. L., ROBERTS, S. A. and HUNTER, R. D., 1993a, Use of low-dose rate to measure the intrinsic radiosensitivity of human T-lymphocytes. International Journal of Radiation Biology, 64, 375-383.
12. ELYAN, S. A. G., WEST, C. M. L., ROBERTS, S. A. and HUNTER, R. D., 1993b, Use of an internal standard in comparative measurements of the intrinsic radiosensitivity of human T-lymphocytes. International Journal of Radiation Biology, 64, 385-391.
13. FORMENTI, S. C., CHAK, L., GILL, P., BUESS, E. M. and HILL, C. K., 1995, Increased radiosensitivity of normal tissue fibroblasts in patients with acquired immunodeficiency syndrome (AIDS) and with Kaposi's sarcoma. International Journal of Radiation Biology, 68, 411-412.
14. GEARA, F. B., PETERS, L. J., ANG, K. K., GARDEN, A. S., TUCKER, S. L., LEVY, L. B. and BROWN, B. W., 1996, Comparison between normal tissue reactions and local tumor control in head and neck cancer patients treated by definitive radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 35, 455-462.
15. GIRINSKY, T., BERNHAI, A., LUBIN, R., et al., 1994, In vitro parameters and treatment outcome in head and neck cancers treated with surgery and/or radiation: cell characterization and correlations with local control and overall survival. International Journal of Radiation Oncology, Biology, Physics, 30, 789-794.
16. HART, R. M., KIMLER, B. F., EVANS, R. G. and PARK, C. H., 1987, Radiotherapeutic management of medulloblastoma in a pediatric patient with ataxia telangiectasia. International Journal of Radiation Oncology, Biology, Physics, 13, 1237-1240.
17. JOHANSEN, J., BENTZEN, S. M., OVERGAARD, J. and OVERGAARD, M., 1996, Relationship between the in vitro radiosensitivity of skin fibroblasts and the expression of subcutaneous fibrosis, telangiectasia, and skin erythema after radiotherapy. Radiotherapy and Oncology, 40, 101-109.
18. KLINE, J. C., BUCHLET, D. A., BOONE, M. L., PECKHAM, B. M. and CARR, W. F., 1972, The relationship of reactions to complications in the radiation therapy of cancer of the cervix. Radiology, 105, 413-416.
19. MACIEJEWSKI, B., WITHERS, H. R., TAYLOR. J. M. and HLINIAK, A., 1990, Dose fractionation and regeneration in radiotherapy for cancer of the oral cavity and oropharynx. Part 2. Normal tissue responses: acute and late effects. International Journal of Radiation Oncology, Biology, Physics, 18, 101-111.
20. MACKAY, R. I., NIEMIERKO, A., GOITEIN, M. and HENDRY, J. H., 1998, Potential clinical impact of normal-tissue intrinsic radiosensitivity testing. Radiotherapy and Oncology, 46, 215-219.
21. PEDERSEN, D., BENTZEN, S. M. and OVERGAARD, J., 1994, Early and late radiotherapeutic morbidity in 442 consecutive patients with locally advanced carcinoma of the uterine cervix. International Journal of Radiation Oncology, Biology, Physics, 29, 941-952.
22. PETERS, L. J., 1990. Inherent radiosensitivity of tumor and normal tissue cells as a predictor of human tumor response. Radiotherapy and Oncology, 17, 177-190.
23. TAYLOR, A. M. R., HARNDEN, D. G., ARLETT, C. F., HARCOURT, S. A., LEHMANN, A. R., STEVENS, S. and BRIDGES, B. A., 1975, Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity. Nature, 258, 427-429.
24. TUCKER, S. L., GEARA, F. B., PETERS, L. J. and BROCK, W. A., 1996, How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity? Radiotherapy and Oncology, 38, 103-113.
25. TUCKER, S. L., TURESSON, I. and THAMES, H. D., 1992. Evidence for individual differences in the radiosensitivity of human skin. European Journal of Cancer, 28A, 1783-1791.
26. TURESSON, I., NYMAN, J., HOLMBERG, E. and ODEN, A., 1996, Prognostic factors for acute and late skin reactions in radiotherapy patients. International Journal of Radiation Oncology, Biology, Physics, 36, 1065-1075.
27. WEST, C. M. L., 1995, Intrinsic radiosensitivity as a predictor of patient response to radiotherapy. British Journal of Radiology, 68, 827-837.
28. WEST, C. M. L., DAVIDSON, S. E., ROBERTS, S. A. and HUNTER, R. D., 1993, Intrinsic radiosensitivity and prediction of patient response to radiotherapy for carcinoma of the cervix. British Journal of Cancer, 68, 819-823.
29. WEST, C. M. L., DAVIDSON, S. E., ROBERTS, S. A. and HUNTER, R. D., 1997, The independence of -ntrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix. British Journal of Cancer, 76, 1184-1190.
30. WEST, C. M. L., ELYAN, S. A. G., BERRY, P., COWAN, R. and SCOTT, D., 1995, A comparison of the radiosensitivity of lymphocytes from normal donors, cancer patients, individuals with ataxia-telangiectasia (A-T) and A-T hetorozygotes. International Journal of Radiation Biology, 68, 197-203.
31. WEST, C. M. L. and HENDRY, J. H., 1992, Intrinsic radiosensitivity as a predictor of patient response 10 radiotherapy. British Journal of Radiology, 24(Suppl.), 146-152.