Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 68, Issue 1, 2003, Pages 47-56

  Cappon, G D ^a,b   Cook, J C ^a   Hurtt, M E ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b PFIZER INC   (United States)

Author keywords

CJ 19,209; Developmental toxicity; Diclofenac; Diflunisal; Ibuprofen; Ketorolac; Meloxicam; Nonsteroidal anti inflammatory drug; Rat; Teratology

Indexed keywords

ACETYLSALICYLIC ACID; CJ 19209; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; DIFLUNISAL; IBUPROFEN; KETOROLAC; MELOXICAM; NONSTEROID ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DEVELOPMENTAL STAGE; DIAPHRAGM HERNIA; DOSE RESPONSE; DRUG EXPOSURE; DRUG SELECTIVITY; FEMALE; FETUS; FETUS DEVELOPMENT; GESTATIONAL AGE; HEART DEVELOPMENT; HEART VENTRICLE SEPTUM DEFECT; INCIDENCE; MAXIMUM TOLERATED DOSE; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; REVIEW;

ABDOMINAL WALL; ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BODY WEIGHT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG ADMINISTRATION SCHEDULE; EATING; FEMALE; FETAL WEIGHT; GASTROSCHISIS; HEART SEPTAL DEFECTS, VENTRICULAR; HERNIA, UMBILICAL; ISOENZYMES; MEMBRANE PROTEINS; PREGNANCY; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER; TERATOGENS;

ORYCTOLAGUS CUNICULUS;

EID: 0141892542     PISSN: 15429733     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdrb.10008     Document Type: Review

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