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Volumn 6, Issue 9, 2003, Pages 886-893

Lapatinib ditosylate GlaxoSmithKline

Author keywords

[No Author keywords available]

Indexed keywords

CANERTINIB; CAPECITABINE; CARBOPLATIN; CETUXIMAB; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLUOROURACIL; GEFITINIB; GROWTH FACTOR RECEPTOR; GW 20168; IRINOTECAN; LAPATINIB; OXALIPLATIN; PROTEIN TYROSINE KINASE INHIBITOR; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 0141719490     PISSN: 13697056     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (12)

References (73)
  • 1
  • 2
    • 0030783173 scopus 로고    scopus 로고
    • Inhibitors of tyrosine kinase
    • 272316; note
    • 272316 Inhibitors of tyrosine kinase. Klohs WD, Fry DW, Kraker AJ Curr Opin Oncol 1997 9 6 562-568 Useful review on TK inhibitors selective for EGFR.
    • (1997) Curr Opin Oncol , vol.9 , Issue.6 , pp. 562-568
    • Klohs, W.D.1    Fry, D.W.2    Kraker, A.J.3
  • 3
    • 85017325712 scopus 로고    scopus 로고
    • Tyrosine kinases in disease: Overview of kinase inhibitors as therapeutic agents and current drugs in clinical trials
    • 286424
    • 286424 Tyrosine kinases in disease: Overview of kinase inhibitors as therapeutic agents and current drugs in clinical trials. Strawn LM, Shawver LK Expert Opin Investig Drugs 1998 7 4 553-573
    • (1998) Expert Opin Investig Drugs , vol.7 , Issue.4 , pp. 553-573
    • Strawn, L.M.1    Shawver, L.K.2
  • 4
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • 303414
    • 303414 Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL Science 1987 235 4785 177-182
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 6
    • 0033063774 scopus 로고    scopus 로고
    • The epidermal growth factor receptor and its inhibition in cancer therapy
    • 352971
    • 352971 The epidermal growth factor receptor and its inhibition in cancer therapy. Woodburn JR Pharmacol Ther 1999 82 2 241-250
    • (1999) Pharmacol Ther , vol.82 , Issue.2 , pp. 241-250
    • Woodburn, J.R.1
  • 7
    • 0033025369 scopus 로고    scopus 로고
    • Inhibition of the epidermal growth factor receptor family of tyrosine kinases as an approach to cancer chemotherapy progression from reversible to irreversible inhibitors
    • 352972
    • 352972 Inhibition of the epidermal growth factor receptor family of tyrosine kinases as an approach to cancer chemotherapy progression from reversible to irreversible inhibitors. Fry DW Pharmacol Ther 1999 82 2 207-218
    • (1999) Pharmacol Ther , vol.82 , Issue.2 , pp. 207-218
    • Fry, D.W.1
  • 8
    • 0032851961 scopus 로고    scopus 로고
    • Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin)
    • 365612
    • 365612 Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin). Sliwkowski MX, Lofgren JA, Lewis GD, Hotaling TE, Fendly BM, Fox JA Semin Oncol 1999 62 4 Suppl 12 60-70
    • (1999) Semin Oncol , vol.62 , Issue.4 SUPPL. 12 , pp. 60-70
    • Sliwkowski, M.X.1    Lofgren, J.A.2    Lewis, G.D.3    Hotaling, T.E.4    Fendly, B.M.5    Fox, J.A.6
  • 9
    • 0032127350 scopus 로고    scopus 로고
    • Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts
    • 365628
    • 365628 Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. Baselga J, Norton L, Albanell J, Kim YM, Mendelsohn J Cancer Res 1998 58 13 2825-2831
    • (1998) Cancer Res , vol.58 , Issue.13 , pp. 2825-2831
    • Baselga, J.1    Norton, L.2    Albanell, J.3    Kim, Y.M.4    Mendelsohn, J.5
  • 10
  • 11
    • 0000061256 scopus 로고    scopus 로고
    • GW2016, a dual inhibitor of ErbB-2 and EGFR tyrosine kinases: Effects on receptor tyrosine autophosphorylation, downstream signaling intermediaries, and in vivo anti-tumor activity
    • 403973; Abs 3635
    • 403973 GW2016, a dual inhibitor of ErbB-2 and EGFR tyrosine kinases: Effects on receptor tyrosine autophosphorylation, downstream signaling intermediaries, and in vivo anti-tumor activity. Xia W, Mullin R, Keith B, Rusnak D, Alligood K, Owens G, Murray D, Crosby R, Finlay C, Gilmer T, Lackey K et al. Proc Annu Meet Am Assoc Cancer Res 2001 42 Abs 3635
    • (2001) Proc Annu Meet Am Assoc Cancer Res , vol.42
    • Xia, W.1    Mullin, R.2    Keith, B.3    Rusnak, D.4    Alligood, K.5    Owens, G.6    Murray, D.7    Crosby, R.8    Finlay, C.9    Gilmer, T.10    Lackey, K.11
  • 12
    • 0033590602 scopus 로고    scopus 로고
    • Augmentation of a humanized anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225
    • 404256
    • 404256 Augmentation of a humanized anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225. Ye D, Mendelsohn J, Fan Z Oncogene 1999 18 3 731-738
    • (1999) Oncogene , vol.18 , Issue.3 , pp. 731-738
    • Ye, D.1    Mendelsohn, J.2    Fan, Z.3
  • 16
    • 0000061252 scopus 로고    scopus 로고
    • The effects of the novel EGFR/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and transformed cell lines
    • 405294; Abs 4309
    • 405294 The effects of the novel EGFR/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and transformed cell lines. Rusnak DW, Affleck K, Gilmer TM, Jowett A, Lackey K, Spector N, Xia W Proc Annu Meet Am Assoc Cancer Res 2001 42 Abs 4309
    • (2001) Proc Annu Meet Am Assoc Cancer Res , vol.42
    • Rusnak, D.W.1    Affleck, K.2    Gilmer, T.M.3    Jowett, A.4    Lackey, K.5    Spector, N.6    Xia, W.7
  • 18
    • 0141485098 scopus 로고    scopus 로고
    • Therapeutic advantage of a dual tyrosine kinase inhibitor (GW2016) in combination with chemotherapy drugs or trastuzumab against human breast cancer cells with HER2 overexpression
    • 447534; Abs 4974
    • 447534 Therapeutic advantage of a dual tyrosine kinase inhibitor (GW2016) in combination with chemotherapy drugs or trastuzumab against human breast cancer cells with HER2 overexpression. Konecny GE, Venkatesan N, Beryt M, Finn R, Slamon DJ, Lackey K, Rusnak DW, Pegram M Proc Annu Meet Am Assoc Cancer Res 2002 43 Abs 4974
    • (2002) Proc Annu Meet Am Assoc Cancer Res , vol.43
    • Konecny, G.E.1    Venkatesan, N.2    Beryt, M.3    Finn, R.4    Slamon, D.J.5    Lackey, K.6    Rusnak, D.W.7    Pegram, M.8
  • 22
    • 0141708469 scopus 로고    scopus 로고
    • Effects of an aldose reductase inhibitor, fidarestat, on the increase of oxidative stress and VEGF production in human retinal pigment epithelial cells exposed to high glucose
    • 454603; Abs 836P
    • 454603 Effects of an aldose reductase inhibitor, fidarestat, on the increase of oxidative stress and VEGF production in human retinal pigment epithelial cells exposed to high glucose. Taniko K, Mukae N, Hirooka H, Kato N, Jomori T Diabetes 2002 51 2 Abs 836P
    • (2002) Diabetes , vol.51 , pp. 2
    • Taniko, K.1    Mukae, N.2    Hirooka, H.3    Kato, N.4    Jomori, T.5
  • 23
    • 0035553174 scopus 로고    scopus 로고
    • The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
    • 454703
    • 454703 The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Rusnak DW, Lackey K, Affleck K, Wood E, Alligood KJ, Rhodes N, Keith BR, Murray DM, Glennon K, Knight WB, Mullin RJ et al. Mol Cancer Ther 2001 1 2 85-94
    • (2001) Mol Cancer Ther , vol.1 , Issue.2 , pp. 85-94
    • Rusnak, D.W.1    Lackey, K.2    Affleck, K.3    Wood, E.4    Alligood, K.J.5    Rhodes, N.6    Keith, B.R.7    Murray, D.M.8    Glennon, K.9    Knight, W.B.10    Mullin, R.J.11
  • 24
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • 454900
    • 454900 Cell signaling by receptor tyrosine kinases. Schlessinger J Cell 2000 103 2 211-225
    • (2000) Cell , vol.103 , Issue.2 , pp. 211-225
    • Schlessinger, J.1
  • 25
    • 0030944455 scopus 로고    scopus 로고
    • ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
    • 454996
    • 454996 ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. Graus-Porta D, Beerli RR, Daly JM, Hynes NE EMBO J 1997 16 7 1647-1655
    • (1997) EMBO J , vol.16 , Issue.7 , pp. 1647-1655
    • Graus-Porta, D.1    Beerli, R.R.2    Daly, J.M.3    Hynes, N.E.4
  • 26
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • 455014
    • 455014 Epidermal growth factor-related peptides and their receptors in human malignancies. Salomon DS, Brandt R, Ciardiello F, Normanno N Crit Rev Oncol Hematol 1995 19 3 183-232
    • (1995) Crit Rev Oncol Hematol , vol.19 , Issue.3 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3    Normanno, N.4
  • 27
    • 0035256698 scopus 로고    scopus 로고
    • Untangling the ErbB signalling network
    • 455345
    • 455345 Untangling the ErbB signalling network. Yarden Y, Sliwkowski MX Nat Rev Mol Cell Biol 2001 2 2 127-137
    • (2001) Nat Rev Mol Cell Biol , vol.2 , Issue.2 , pp. 127-137
    • Yarden, Y.1    Sliwkowski, M.X.2
  • 28
    • 0032479006 scopus 로고    scopus 로고
    • Prognostic applications of the epidermal growth factor receptor and its ligand, transforming growth factor-α
    • 460591
    • 460591 Prognostic applications of the epidermal growth factor receptor and its ligand, transforming growth factor-α. Wikstrand CJ, Bigner DD J Natl Cancer Inst 1998 90 11 799-801
    • (1998) J Natl Cancer Inst , vol.90 , Issue.11 , pp. 799-801
    • Wikstrand, C.J.1    Bigner, D.D.2
  • 29
    • 0034597662 scopus 로고    scopus 로고
    • Enhanced drug resistance in cells coexpressing ErbB2 with EGF receptor or ErbB3
    • 460593
    • 460593 Enhanced drug resistance in cells coexpressing ErbB2 with EGF receptor or ErbB3. Chen X, Yeung TK, Wang Z Biochem Biophys Res Commun 2000 277 3 757-763
    • (2000) Biochem Biophys Res Commun , vol.277 , Issue.3 , pp. 757-763
    • Chen, X.1    Yeung, T.K.2    Wang, Z.3
  • 30
    • 0023686033 scopus 로고
    • Signal transduction by allosteric receptor oligomerization
    • 460597
    • 460597 Signal transduction by allosteric receptor oligomerization. Schlessinger J Trends Biochem Sci 1988 13 11 443-447
    • (1988) Trends Biochem Sci , vol.13 , Issue.11 , pp. 443-447
    • Schlessinger, J.1
  • 31
    • 0345487906 scopus 로고    scopus 로고
    • Product development pipeline - October 2002
    • 467734; October 23
    • 467734 Product development pipeline - October 2002. GlaxoSmithKline Plc Company Publication 2002 October 23
    • (2002) GlaxoSmithKline Plc Company Publication
  • 32
    • 10744230853 scopus 로고    scopus 로고
    • A phase III clinical trial of ZD1839 in combination with gemcitabine and cisplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer (INTACT 1)
    • 471987; Abs 4
    • 471987 A phase III clinical trial of ZD1839 in combination with gemcitabine and cisplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer (INTACT 1). Giaccone G, Johnson DH, Manegold C, Scagliotti GV, Rosell R, Wolf M, Rennie P, Ochs J, Averbuch S, Faudi A Proc Eur Med Soc Oncol 2002 2 Abs 4
    • (2002) Proc Eur Med Soc Oncol , vol.2
    • Giaccone, G.1    Johnson, D.H.2    Manegold, C.3    Scagliotti, G.V.4    Rosell, R.5    Wolf, M.6    Rennie, P.7    Ochs, J.8    Averbuch, S.9    Faudi, A.10
  • 33
    • 0141596717 scopus 로고    scopus 로고
    • American Association of Pharmaceutical Scientists 2002 Annual Meeting and Exposition (Part III) - Toronto, Canada
    • 472744
    • 472744 American Association of Pharmaceutical Scientists 2002 Annual Meeting and Exposition (Part III) - Toronto, Canada. Koushik K, Kompella U IDDB Meeting Report 2002 November 10-14
    • IDDB Meeting Report 2002 November 10-14
    • Koushik, K.1    Kompella, U.2
  • 34
    • 0037068741 scopus 로고    scopus 로고
    • Anti-tumor activity of GW572016: A dual tyrosine kinase inhibitor blocks EGF activation of EGFR/ErbB2 and downstream Erk1/2 and AKT pathways
    • 474696
    • 474696 Anti-tumor activity of GW572016: A dual tyrosine kinase inhibitor blocks EGF activation of EGFR/ErbB2 and downstream Erk1/2 and AKT pathways. Xia W, Mullin RJ, Keith BR, Liu LH, Ma H, Rusnak DW, Owens G, Alligood KJ, Spector NL Oncogene 2002 21 41 6255-6263
    • (2002) Oncogene , vol.21 , Issue.41 , pp. 6255-6263
    • Xia, W.1    Mullin, R.J.2    Keith, B.R.3    Liu, L.H.4    Ma, H.5    Rusnak, D.W.6    Owens, G.7    Alligood, K.J.8    Spector, N.L.9
  • 35
    • 0141596716 scopus 로고    scopus 로고
    • Product development pipeline - December 2002
    • 478510; February 12
    • 478510 Product development pipeline - December 2002. GlaxoSmithKline Plc Company Publication 2003 February 12
    • (2003) GlaxoSmithKline Plc Company Publication
  • 36
    • 0036316380 scopus 로고    scopus 로고
    • Potential benefits of the irreversible pan-ErbB inhibitor, CI-1033, in the treatment of breast cancer
    • 483258
    • 483258 Potential benefits of the irreversible pan-ErbB inhibitor, CI-1033, in the treatment of breast cancer. Allen LF, Lenehan PF, Eiseman IA, Elliott WL, Fry DW Semin Oncol 2002 29 3 Suppl 11 11-21
    • (2002) Semin Oncol , vol.29 , Issue.3 SUPPL. 11 , pp. 11-21
    • Allen, L.F.1    Lenehan, P.F.2    Eiseman, I.A.3    Elliott, W.L.4    Fry, D.W.5
  • 37
    • 0019332558 scopus 로고
    • Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity
    • 489651
    • 489651 Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity. Cohen S, Carpenter G, King L J Biol Chem 1980 255 10 4834-4842
    • (1980) J Biol Chem , vol.255 , Issue.10 , pp. 4834-4842
    • Cohen, S.1    Carpenter, G.2    King, L.3
  • 38
    • 0022600388 scopus 로고
    • The neu oncogene encodes an epidermal growth factor receptor-related protein
    • 489652
    • 489652 The neu oncogene encodes an epidermal growth factor receptor-related protein. Bargmann CI, Hung MC, Weinberg RA Nature 1986 319 6050 226-230
    • (1986) Nature , vol.319 , Issue.6050 , pp. 226-230
    • Bargmann, C.I.1    Hung, M.C.2    Weinberg, R.A.3
  • 39
    • 0024326947 scopus 로고
    • Isolation and characterization of ErbB3, a third member of the ErbB/epidermal growth factor receptor family: Evidence for overexpression in a subset of human mammary tumors
    • 489653
    • 489653 Isolation and characterization of ErbB3, a third member of the ErbB/epidermal growth factor receptor family: Evidence for overexpression in a subset of human mammary tumors. Kraus MH, Issing W, Miki T, Popescu NC, Aaronson SA Proc Natl Acad Sci USA 1989 86 23 9193-9197
    • (1989) Proc Natl Acad Sci USA , vol.86 , Issue.23 , pp. 9193-9197
    • Kraus, M.H.1    Issing, W.2    Miki, T.3    Popescu, N.C.4    Aaronson, S.A.5
  • 41
    • 0029814271 scopus 로고    scopus 로고
    • A hierarchical network of interreceptor interactions determines signal transduction by neu differentiation factor/neuregulin and epidermal growth factor
    • 489661
    • 489661 A hierarchical network of interreceptor interactions determines signal transduction by neu differentiation factor/neuregulin and epidermal growth factor. Tzahar E, Waterman H, Chen X, Levkowitz G, Karunagaran D, Lavi S, Ratzkin BJ, Yarden Y Mol Cell Biol 1996 16 10 5276-5287
    • (1996) Mol Cell Biol , vol.16 , Issue.10 , pp. 5276-5287
    • Tzahar, E.1    Waterman, H.2    Chen, X.3    Levkowitz, G.4    Karunagaran, D.5    Lavi, S.6    Ratzkin, B.J.7    Yarden, Y.8
  • 42
  • 43
    • 0024395587 scopus 로고
    • Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts
    • 489663
    • 489663 Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts. Kokai Y, Myers JN, Wada T, Brown VI, LeVea CM, Davis JG, Dobashi K, Greene MI Cell 1989 58 2 287-292
    • (1989) Cell , vol.58 , Issue.2 , pp. 287-292
    • Kokai, Y.1    Myers, J.N.2    Wada, T.3    Brown, V.I.4    Levea, C.M.5    Davis, J.G.6    Dobashi, K.7    Greene, M.I.8
  • 44
    • 0027421389 scopus 로고
    • Interaction of the neu/p185 and EGF receptor tyrosine kinases: Implications for cellular transformation and tumor therapy
    • 489664
    • 489664 Interaction of the neu/p185 and EGF receptor tyrosine kinases: Implications for cellular transformation and tumor therapy. Dougall WC, Qian X, Greene MI J Cell Biochem 1993 53 1 61-73
    • (1993) J Cell Biochem , vol.53 , Issue.1 , pp. 61-73
    • Dougall, W.C.1    Qian, X.2    Greene, M.I.3
  • 45
    • 0034600849 scopus 로고    scopus 로고
    • The ErbB signaling network: Receptor heterodimerization in development and cancer
    • 489670
    • 489670 The ErbB signaling network: Receptor heterodimerization in development and cancer. Olayioye MA, Neve RM, Lane HA, Hynes NE EMBO J 2000 19 13 3159-3167
    • (2000) EMBO J , vol.19 , Issue.13 , pp. 3159-3167
    • Olayioye, M.A.1    Neve, R.M.2    Lane, H.A.3    Hynes, N.E.4
  • 46
    • 7144227965 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials
    • 489672
    • 489672 Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials. Voldborg BR, Damstrup L, Spang-Thomsen M, Poulsen HS Ann Oncol 1997 8 12 1197-1206
    • (1997) Ann Oncol , vol.8 , Issue.12 , pp. 1197-1206
    • Voldborg, B.R.1    Damstrup, L.2    Spang-Thomsen, M.3    Poulsen, H.S.4
  • 47
    • 0022485548 scopus 로고
    • Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185
    • 489673
    • 489673 Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Bargmann CI, Hung MC, Weinberg RA Cell 1986 45 5 649-657
    • (1986) Cell , vol.45 , Issue.5 , pp. 649-657
    • Bargmann, C.I.1    Hung, M.C.2    Weinberg, R.A.3
  • 48
    • 0023733226 scopus 로고
    • Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the ErbB-2 gene
    • 489675
    • 489675 Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the ErbB-2 gene. Segatto O, King CR, Pierce JH, Di Fiore PP, Aaronson SA Mol Cell Biol 1988 8 12 5570-5574
    • (1988) Mol Cell Biol , vol.8 , Issue.12 , pp. 5570-5574
    • Segatto, O.1    King, C.R.2    Pierce, J.H.3    Di Fiore, P.P.4    Aaronson, S.A.5
  • 49
    • 0024505028 scopus 로고
    • A point mutation in the neu oncogene mimics ligand induction of receptor aggregation
    • 489676
    • 489676 A point mutation in the neu oncogene mimics ligand induction of receptor aggregation. Weiner DB, Liu J, Cohen JA, Williams WV, Greene MI Nature 1989 339 6221 230-231
    • (1989) Nature , vol.339 , Issue.6221 , pp. 230-231
    • Weiner, D.B.1    Liu, J.2    Cohen, J.A.3    Williams, W.V.4    Greene, M.I.5
  • 50
    • 0027012928 scopus 로고
    • c-ErbB2 amplification and overexpression in human tumors
    • 489680
    • 489680 c-ErbB2 amplification and overexpression in human tumors. Lofts FJ, Gullick WJ Cancer Treat Res 1992 61 161-179
    • (1992) Cancer Treat Res , vol.61 , pp. 161-179
    • Lofts, F.J.1    Gullick, W.J.2
  • 52
    • 0025073536 scopus 로고
    • Expression of epidermal growth factor receptor and HER-2/neu in normal and neoplastic cervix, vulva, and vagina
    • 489690
    • 489690 Expression of epidermal growth factor receptor and HER-2/neu in normal and neoplastic cervix, vulva, and vagina. Berchuck A, Rodriguez G, Kamel A, Soper JT, Clarke Pearson DL, Bast RC Obstet Gynecol 1990 76 3 Pt 1 381-387
    • (1990) Obstet Gynecol , vol.76 , Issue.3 PART 1 , pp. 381-387
    • Berchuck, A.1    Rodriguez, G.2    Kamel, A.3    Soper, J.T.4    Clarke Pearson, D.L.5    Bast, R.C.6
  • 53
    • 0030611147 scopus 로고    scopus 로고
    • Epidermal growth factor receptor, c-ErbB-2 and p53 overexpressions in epithelial hyperplastic lesions of the larynx
    • 489693
    • 489693 Epidermal growth factor receptor, c-ErbB-2 and p53 overexpressions in epithelial hyperplastic lesions of the larynx. Gale N, Zidar N, Kambic V, Poljak M, Cor A Acta Otolaryngol Suppl 1997 527 105-110
    • (1997) Acta Otolaryngol Suppl , vol.527 , pp. 105-110
    • Gale, N.1    Zidar, N.2    Kambic, V.3    Poljak, M.4    Cor, A.5
  • 54
    • 0031865433 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor family proteins (EGFR, c-ErbB-2 and c-ErbB-3) in gastric cancer and chronic gastritis
    • 489698
    • 489698 Expression of epidermal growth factor receptor family proteins (EGFR, c-ErbB-2 and c-ErbB-3) in gastric cancer and chronic gastritis. Slesak B, Harlozinska A, Porebska I, Bojarowski T, Lapinska J, Rzeszutko M, Wojnar A Anticancer Res 1998 18 4A 2727-2732
    • (1998) Anticancer Res , vol.18 , Issue.4 A , pp. 2727-2732
    • Slesak, B.1    Harlozinska, A.2    Porebska, I.3    Bojarowski, T.4    Lapinska, J.5    Rzeszutko, M.6    Wojnar, A.7
  • 55
    • 0343819997 scopus 로고    scopus 로고
    • Expression of the tyrosine kinase activity growth factor receptors (EGFR, Erb B2, Erb B3) in colorectal adenocarcinomas and adenomas
    • 489702
    • 489702 Expression of the tyrosine kinase activity growth factor receptors (EGFR, Erb B2, Erb B3) in colorectal adenocarcinomas and adenomas. Porebska I, Harlozinska A, Bojarowski T Tumor Biol 2000 21 2 105-115
    • (2000) Tumor Biol , vol.21 , Issue.2 , pp. 105-115
    • Porebska, I.1    Harlozinska, A.2    Bojarowski, T.3
  • 56
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
    • 489708
    • 489708 Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. Cobleigh MA, Vogel CL, Tripathy D, Robert NJ, Scholl S, Fehrenbacher L, Wolter JM, Paton V, Shak S, Lieberman G, Slamon DJ J Clin Oncol 1999 17 9 2639-2648
    • (1999) J Clin Oncol , vol.17 , Issue.9 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3    Robert, N.J.4    Scholl, S.5    Fehrenbacher, L.6    Wolter, J.M.7    Paton, V.8    Shak, S.9    Lieberman, G.10    Slamon, D.J.11
  • 57
    • 0031974705 scopus 로고    scopus 로고
    • Therapeutic application of anti-growth factor receptor antibodies
    • 489716
    • 489716 Therapeutic application of anti-growth factor receptor antibodies. Fan Z, Mendelsohn J Curr Opin Oncol 1998 10 1 67-73
    • (1998) Curr Opin Oncol , vol.10 , Issue.1 , pp. 67-73
    • Fan, Z.1    Mendelsohn, J.2
  • 58
    • 2442659899 scopus 로고    scopus 로고
    • Perspectives on anti-HER monoclonal antibodies
    • 489741
    • 489741 Perspectives on anti-HER monoclonal antibodies. Ransom M, Sliwkowski MX Oncology 2002 63 Suppl 1 17-24
    • (2002) Oncology , vol.63 , Issue.SUPPL. 1 , pp. 17-24
    • Ransom, M.1    Sliwkowski, M.X.2
  • 59
    • 0024822342 scopus 로고
    • Epidermal growth factor receptors in breast cancer: Association with early relapse and death, poor response to hormones and interactions with neu
    • 489742
    • 489742 Epidermal growth factor receptors in breast cancer: Association with early relapse and death, poor response to hormones and interactions with neu. Harris AL, Nicholson S, Sainsbury JR, Farndon J, Wright C J Steroid Biochem 1989 34 1-6 123-131
    • (1989) J Steroid Biochem , vol.34 , Issue.1-6 , pp. 123-131
    • Harris, A.L.1    Nicholson, S.2    Sainsbury, J.R.3    Farndon, J.4    Wright, C.5
  • 61
    • 0030741967 scopus 로고    scopus 로고
    • Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma
    • 489744
    • 489744 Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma. Gilbertson RJ, Perry RH, Kelly PJ, Pearson AD, Lunec J Cancer Res 1997 57 15 3272-3280
    • (1997) Cancer Res , vol.57 , Issue.15 , pp. 3272-3280
    • Gilbertson, R.J.1    Perry, R.H.2    Kelly, P.J.3    Pearson, A.D.4    Lunec, J.5
  • 62
    • 0028156927 scopus 로고
    • Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: A mechanism of interreceptor kinase activation and transphosphorylation
    • 489745
    • 489745 Heterodimerization of epidermal growth factor receptor and wild-type or kinase-deficient Neu: A mechanism of interreceptor kinase activation and transphosphorylation. Qian X, LeVea CM, Freeman JK, Dougall WC, Greene MI Proc Natl Acad Sci USA 1994 91 4 1500-1504
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.4 , pp. 1500-1504
    • Qian, X.1    LeVea, C.M.2    Freeman, J.K.3    Dougall, W.C.4    Greene, M.I.5
  • 64
    • 0033168414 scopus 로고    scopus 로고
    • Overexpression of ErbB2 impairs ligand-dependent downregulation of epidermal growth factor receptors via a post-transcriptional mechanism
    • 489848
    • 489848 Overexpression of ErbB2 impairs ligand-dependent downregulation of epidermal growth factor receptors via a post-transcriptional mechanism. Huang G, Chantry A, Epstein RJ J Cell Biochem 1999 74 1 23-30
    • (1999) J Cell Biochem , vol.74 , Issue.1 , pp. 23-30
    • Huang, G.1    Chantry, A.2    Epstein, R.J.3
  • 65
    • 0035888069 scopus 로고    scopus 로고
    • Truncated ErbB2 receptor enhances ErbB1 signaling and induces reversible, ERK-independent loss of epithelial morphology
    • 489850
    • 489850 Truncated ErbB2 receptor enhances ErbB1 signaling and induces reversible, ERK-independent loss of epithelial morphology. Egeblad M, Mortensen OH, Jaattela M Int J Cancer 2001 94 2 185-191
    • (2001) Int J Cancer , vol.94 , Issue.2 , pp. 185-191
    • Egeblad, M.1    Mortensen, O.H.2    Jaattela, M.3
  • 66
    • 0033605560 scopus 로고    scopus 로고
    • ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors
    • 489851
    • 489851 ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors. Worthylake R, Opresko LK, Wiley HS J Biol Chem 1999 274 13 8865-8874
    • (1999) J Biol Chem , vol.274 , Issue.13 , pp. 8865-8874
    • Worthylake, R.1    Opresko, L.K.2    Wiley, H.S.3
  • 67
    • 0036225446 scopus 로고    scopus 로고
    • Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth
    • 489860
    • 489860 Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth. Normanno N, Campiglio M, De LA, Somenzi G, Maiello M, Ciardiello F, Gianni L, Salomon DS, Menard S Ann Oncol 2002 13 1 65-72
    • (2002) Ann Oncol , vol.13 , Issue.1 , pp. 65-72
    • Normanno, N.1    Campiglio, M.2    De, L.A.3    Somenzi, G.4    Maiello, M.5    Ciardiello, F.6    Gianni, L.7    Salomon, D.S.8    Menard, S.9
  • 68
    • 0347955437 scopus 로고    scopus 로고
    • A phase II, open-label, multicenter study of GW572016 in patients with metastatic colorectal cancer refractory to 5-FU in combination with irinotecan and/or oxaliplatin
    • 492986; Abs 978
    • 492986 A phase II, open-label, multicenter study of GW572016 in patients with metastatic colorectal cancer refractory to 5-FU in combination with irinotecan and/or oxaliplatin. Belanger M, Jones CM, Germond C, Berger MS Proc Am Soc Clin Oncol 2002 22 Abs 978
    • (2003) Proc Am Soc Clin Oncol , vol.22
    • Belanger, M.1    Jones, C.M.2    Germond, C.3    Berger, M.S.4
  • 69
    • 0141819722 scopus 로고    scopus 로고
    • A phase II, open-label, multicenter study of GW572016 in patients with trastuzumab refractory metastatic breast cancer
    • 492991; Abs 981
    • 492991 A phase II, open-label, multicenter study of GW572016 in patients with trastuzumab refractory metastatic breast cancer. Kaplan EH, Jones CM, Berger MS Proc Am Soc Clin Oncol 2003 22 Abs 981
    • (2003) Proc Am Soc Clin Oncol , vol.22
    • Kaplan, E.H.1    Jones, C.M.2    Berger, M.S.3
  • 71
    • 0141708467 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic (PK) study of oral GW572016, a potent reversible dual inhibitor of both ErbB1 and ErbB2 tyrosine kinase (TK), administered in combination with capecitabine
    • 493275; Abs 901
    • 493275 Phase I and pharmacokinetic (PK) study of oral GW572016, a potent reversible dual inhibitor of both ErbB1 and ErbB2 tyrosine kinase (TK), administered in combination with capecitabine. De Bono JS, Schwartz G, Monroe P, Beeram M, Hammond L, Smith D, Loftiss J, Stead A, Pandite L, Rowinsky EK Proc Am Soc Clin Oncol 2003 22 Abs 901
    • (2003) Proc Am Soc Clin Oncol , vol.22
    • De Bono, J.S.1    Schwartz, G.2    Monroe, P.3    Beeram, M.4    Hammond, L.5    Smith, D.6    Loftiss, J.7    Stead, A.8    Pandite, L.9    Rowinsky, E.K.10
  • 72
    • 0344341539 scopus 로고    scopus 로고
    • Safety, clinical efficacy, and biologic assessments from EGF100004: A randomized phase IB study of GW572016 for patients with metastatic carcinomas overexpressing EGFR or ErbB2
    • 493292; Abs 772
    • 493292 Safety, clinical efficacy, and biologic assessments from EGF100004: A randomized phase IB study of GW572016 for patients with metastatic carcinomas overexpressing EGFR or ErbB2. Spector N, Raefsky E, Hurwitz H, Hensing T, Dowalti A, Dees C, O'Neill B, Smith DA, Mangum S, Burris HA Proc Am Soc Clin Oncol 2003 22 Abs 772
    • (2003) Proc Am Soc Clin Oncol , vol.22
    • Spector, N.1    Raefsky, E.2    Hurwitz, H.3    Hensing, T.4    Dowalti, A.5    Dees, C.6    O'Neill, B.7    Smith, D.A.8    Mangum, S.9    Burris, H.A.10
  • 73
    • 0000780450 scopus 로고    scopus 로고
    • ZD1839 ('Iressa') in combination with paclitaxel & carboplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (NSCLC): Results from a phase III clinical trial (INTACT 2)
    • 493445; Abs 4680
    • 493445 ZD1839 ('Iressa') in combination with paclitaxel & carboplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (NSCLC): Results from a phase III clinical trial (INTACT 2). Johnson DH, Herbst R, Giaccone G, Schiller J, Natale RB, Miller V, Wolf M, Helton A, Averbuch S, Grous J Ann Oncol 2002 13 Suppl 5 Abs 4680
    • (2002) Ann Oncol , vol.13 , Issue.SUPPL. 5
    • Johnson, D.H.1    Herbst, R.2    Giaccone, G.3    Schiller, J.4    Natale, R.B.5    Miller, V.6    Wolf, M.7    Helton, A.8    Averbuch, S.9    Grous, J.10


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