Overexpression of ErbB2 impairs ligand-dependent downregulation of epidermal growth factor receptors via a post-transcriptional mechanism

Journal of Cellular Biochemistry

Volumn 74, Issue 1, 1999, Pages 23-30

  Huang, Guocai ^a   Chantry, Andrew ^b   Epstein, Richard J ^b,c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c DIVISION OF MEDICAL ONCOLOGY   (Singapore)

Author keywords

Downregulation; EGF receptor; ErbB2; Growth substances

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL STRAIN 3T3; CONTROLLED STUDY; GENE OVEREXPRESSION; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTO ONCOGENE; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0033168414     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19990701)74:1<23::AID-JCB3>3.0.CO;2-L     Document Type: Article

References (52)

1. Allred DC, Clark GM, Tandon AK, Molina R, Tormey DC, Osborne CK, Gilchrist KW, Mansour EG, Abeloff M, Eudey L, et al. 1992. HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma. J Clin Oncol 10:599-605.
2. Bargmann CI, Hung M, Weinberg RA. 1986. The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature 319:226-230.
3. Baulida J, Kraus MH, Alimandi M, Di Fiore PP, Carpenter G. 1996. All erbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J Biol Chem 271:5251-5257.
4. Chantry A. 1995. The kinase domain and membrane localization determine intracellular interactions between epidermal growth factor receptors. J Biol Chem 270:3068-3073.
5. Chen C, Okayama H. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7:2745-2752.
6. Decker SJ, Alexander C, Habib T. 1992. Epidermal growth factor (EGF)-stimulated tyrosine phosphorylation and EGF receptor degradation in cells expressing EGF receptors truncated at residue 973. J Biol Chem 267:1104-1108.
7. Di Fiore PP, Pierce JH, Kraus KH, Segatto D, King CR, Aaronson SA. 1987. erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science 237:178-181.
8. Di Marco E, Pierce JH, Knicley CL, DiFiore PP. 1990. Transformation of NIH 3T3 cells by overexpression of the normal coding sequence of the rat neu gene. Mol Cell Biol 10:3247-3252.
9. Epstein RJ. 1995. Preferential detection of catalytically inactive c-erbB-2 by antibodies to unphosphorylated peptides mimicking receptor tyrosine autophosphorylation sites. Oncogene 11:315-323.
10. r 175,000 c-neu receptor isoform in G8/DHFR cells by serum starvation. J Biol Chem 265:10746-10751.
11. Felder S, Miller K, Moehren G, Ullrich A, Schlessinger J, Hopkins CR. 1990. Kinase activity controls the sorting of epidermal growth factor receptor within the multivesicular body. Cell 61:623-634.
12. French AR, Sudlow GP, Wiley HS, Lauffenburger DA. 1994. Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions. J Biol Chem 269:15749-15755.
13. Galcheva-Gargova Z, Theroux SJ, Davis RJ. 1995. The epidermal growth factor receptor is covalently linked to ubiquitin. Oncogene 11:2649-2655.
14. Glenney JR, Chen WS, Lazar CS, Walton GM, Zokas LM, Rosenfeld MG, Gill GN. 1988. Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of antiphosphotyrosine antibodies. Cell 52:675-684.
15. Gulliford T, Huang GC, Ouyang X, Epstein RJ. 1997. Reduced ability of transforming growth factor-alpha to induce hetero-oligomerization and downregulation of EGFR suggests a mechanism of oncogenic synergy with ErbB2. Oncogene 15:2219-2223.
16. Helin K, Beguinot L. 1991. Internalization and down regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines. J Biol Chem 266:8363-8368.
17. Hoffman P, Carlin C. 1994. Adenovirus E3 protein causes constitutively internalized epidermal growth factor receptors to accumulate in a prelysosomal compartment, resulting in enhanced degradation. Mol Cell Biol 14:3695-3706.
18. Hopkins CR. 1992. Selective membrane protein trafficking: vectorial flow and filter. Trends Biochem Sci 17:27-32.
19. Huang GC, Ouyang X, Epstein RJ. 1998. Proxy activation of ErbB2 by heterologous ligands suggests a heterotetrameric mechanism of receptor tyrosine kinase interaction. Biochem J 331:113-119.
20. Huang HS, Nagane M, Klingbeil CK. 1997. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem 272:2927-2935.
21. Kawamoto T, Sato JD, Le A, Polikoff J, Sato GH, Mendelsohn J. 1983. Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proc Natl Acad Sci USA 80:1337-1341.
22. King CR, Borrello I, Bellot F, Comoglio P, Schlessinger J. 1988. EGF binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3. EMBO J 7:1647-1651.
23. King I, Sartorelli AC. 1989. Epidermal growth factor receptor gene expression, protein kinase activity, and terminal differentiation of human malignant epidermal cells. Cancer Res 49:5677-5681.
24. Kokai Y, Myers JN, Wada T, Brown VI, LeVea CM, Davis JG, Dobashi K, Greene MI. 1989. Synergistic interaction of p185/c-neu and the EGF receptor leads to transformation of rodent fibroblasts. Cell 58:287-292.
25. Kornilova E, Sorkina T, Beguinot L, Sorkin A. 1996. Lysosomal targeting of epidermal growth factor receptors via a kinase-dependent pathway is mediated by the receptor carboxyterminal residues 1022-1123. J Biol Chem 271: 30340-30346.
26. Kurten RC, Cadena DL, Gill GN. 1996. Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Science 272:1008-1010.
27. Kwatra MM, Bigner DD, Cohn JA. 1992. The ligand binding domain of the epidermal growth factor receptor is not required for receptor dimerization. Biochim Biophys Acta 1134:178-181.
28. Lamaze C, Schmid SL. 1995. Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase. J Cell Biol 129:47-54.
29. Lemoine NR, Staddon S, Dickson C, Barnes DM, Gullick WJ. 1990. Absence of activating transmembrane mutations in the c-erbB-2 proto-oncogene in human breast cancer. Oncogene 5:237-239.
30. Lenferink AE, Pinkas-Kramarski R, van de Poll ML, van Vugt MJ, Klapper LN, Tzahar E, Waterman H, Sela M, van Zoelen EJ, Yarden Y. 1998. Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J 17:3385-3397.
31. c-crbB-2 receptor protein-tyrosine kinase induced by geldenamycin. J Biol Chem 271:22796-22801.
32. Mori S, Tanaka K, Omura S, Saito Y. 1995. Degradation process of ligand-stimulated platelet-derived growth factor β-receptor involves ubiquitin-proteasome proteolytic pathway. J Biol Chem 270:29447-29452.
33. Muller WJ, Arteaga CL, Muthuswamy SK, et al. 1996. Synergistic interaction of the neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice. Mol Cell Biol 16:5726-5736.
34. Nesterov A, Wiley HS, Gill GN. 1995. Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins. Proc Natl Acad Sci USA 92:8719-8723.
35. Opresko LK, Chang C, Will BH, Burke PM, Gill GN, Wiley HS. 1995. Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain. J Biol Chem 270:4325-4333.
36. Oshima M, Weiss L, Dougall WC, Greene MI, Guroff G. 1995. Down-regulation of c-neu receptors by nerve growth factor in PC12 cells. J Neurochem 65:427-433.
37. Ouyang X, Gulliford T, Chantry A, Epstein RJ. 1996. Human cancer cells exhibit protein kinase C-dependent c-erbB-2 transmodulation which correlate with phosphatase sensitivity and kinase activity. J Biol Chem 271: 21786-21792.
38. Ouyang X, Gulliford T, Huang GC, Epstein RJ. 1999. Transforming growth factor-alpha short-circuits downregulation of the epidermal growth factor receptor. J Cell Physiol (in press)
39. Pandit SD, Donis-Keller H, Iwamoto T, Tomich JM, Pike LJ. 1996. The multiple endocrine neoplasia type 2B point mutation alters long-term regulation and enhances the transforming capacity of the epidermal growth factor receptor. J Biol Chem 271:5850-5858.
40. Reiss M, Stash EB, Vellucci VF, Zhou Z. 1991. Activation of the autocrine transforming growth factor alpha pathway in human squamous carcinoma cells. Cancer Res 51:6254-6262.
41. Robinson MS. 1987. 100-kD coated vesicle proteins: molecular heterogeneity and intracellular distribution studied with monoclonal antibodies. J Cell Biol 104:887-895.
42. Skehan P, Storeng R, Scudeiro D, et al. 1990. New colorimetric cytotoxicity assay for anticancer drug screening. J Natl Cancer Inst 82:1107-1112.
43. Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. 1987. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177-182.
44. Sorkin A, Carpenter G. 1993. Interaction of activated EGF receptors with coated pit adapting. Science 261:612-615.
45. 974-containing internalization motif. J Biol Chem 271:13377-13384.
46. Sorkin A, McKinsey T, Shih W, Kirchhausen T, Carpenter G. 1995. Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2. J Biol Chem 270:619-625.
47. Stoscheck CM, Carpenter G. 1984. Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts. J Cell Biol 98:1048-1053.
48. Towbin H, Staehelin T, Gordon J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354.
49. Ullrich A, Schlessinger J. 1990. Signal transduction by receptors with tyrosine kinase activity. Cell 61:203-212.
50. van de Vijver MJ, Kumar R, Mendelsohn J. 1991. Ligand-induced activation of A431 cell epidermal growth factor receptors occurs primarily by an autocrine pathway that acts upon receptors on the surface rather than intracellularly. J Biol Chem 266:7503-7508.
51. Warren RA, Green FA, Enns CA. 1997. Saturation of the endocytic pathway for the transferrin receptor does not affect the endocytosis of the epidermal growth factor receptor. J Biol Chem 272:2116-2121.
52. Wells A, Welsh J, Lazar C, Wiley H, Gill G, Rosenfeld M. 1990. Ligand-induced transformation by a noninternalizing epidermal growth factor receptor. Science 247:962-964.