Toll-like receptor 5-mediated corneal epithelial inflammatory responses to Pseudomonas aeruginosa flagellin

Investigative Ophthalmology and Visual Science

Volumn 44, Issue 10, 2003, Pages 4247-4254

  Zhang, Jing ^a   Xu, Keping ^a   Ambati, Balamurali ^a   Yu, Fu Shin X ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLAGELLIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 5; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL FLAGELLUM; CONTROLLED STUDY; CORNEA EPITHELIUM; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; KERATITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

ANTIBODIES, BLOCKING; BLOTTING, WESTERN; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIUM, CORNEAL; FLAGELLIN; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; I-KAPPA B PROTEINS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; MEMBRANE GLYCOPROTEINS; PHOSPHORYLATION; PSEUDOMONAS AERUGINOSA; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 5; TOLL-LIKE RECEPTORS;

EID: 0141653750     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.03-0219     Document Type: Article

References (44)

1. Cohen E, Laibson P, Arentsen J, Clemons C. Comeal ulcers associated with cosmetic extended wear soft contact lenses. Ophthalmology. 1987;94:109-114.
2. Ogawa G, Hyndiuk R. Bacterial keratitis and conjunctivitis. In: Smolin G, Thoft R, eds. The Cornea. Boston: Little, Brown; 1994:125-167.
3. Lyczak JB, Cannon CL, Pier GB. Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microbes Infect. 2000;2:1051-1060.
4. Kurpakus-Wheater M, Kernacki KA, Hazlett LD. Maintaining corneal integrity how the "window" stays clear. Prog Histochem Cytochem. 2001;36:185-259.
5. Fleiszig S, Arora S, Van R, Ramphal R. FlhA, a component of the flagellum assembly apparatus of Pseudomonas aeruginosa, plays a role in internalization by corneal epithelial cells. Infect Immun. 2001;69:4931-4937.
6. Philpott DJ, Girardin SE, Sansonetti PJ. Innate immune responses of epithelial cells following infection with bacterial pathogens. Curr Opin Immunol. 2001;13:410-416.
7. Eaves-Pyles T, Murthy K, Liaudet L, et al. Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction. J Immunol. 2001;166:1248-1260.
8. Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory, gene expression. J Immunol. 2001;167:1882-1885.
9. DiMango E, Zar HJ, Bryan R, Prince A. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J Clin Invest. 1995;96:2204-2210.
10. Feldman M, Bryan R, Rajan S, et al. Role of Flagella in pathogenesis of Pseudomonas aeruginosa, pulmonary, infection. Infect Immun. 1998;66:43-51.
11. Ramphal R, Arora SK, Ritchings BW. Recognition of mucin by the adhesin-flagellar system of Pseudomonas aeruginosa. Am J Respir Crit Care Med. 1996;154:S170-S174.
12. Steiner TS, Nataro JP, Poteet-Smith CE, Smith JA, Guerrant RL. Enteroaggregative Escherichia coli expresses a novel flagellin that causes IL-8 release from intestinal epithelial cells. J Clin Invest. 2000;105:1769-1777.
13. Hayashi F, Smith KD, Ozinsky A, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 410:1099-1103.
14. Gewirtz AT, Simon PO, Jr, Schmitt CK, et al. Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response. J Clin Invest. 2001;107:99-109.
15. Sierro F, Dubois B, Coste A, Kaiserlian D, Kraehenhuhl JP, Sirard JC. Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells. Proc Natl Acad Sci USA. 98:13722-13727.
16. Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol. 2001;1:135-145.
17. Medzhitov R, Janeway C Jr. Innate immunity. N Engl J Med. 2000;343:338-344.
18. Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol. 2002;20:197-216.
19. Medvedev AE, Kopydlowski KM, Vogel SN. Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression. J Immunol. 2000;164:5564-5574.
20. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2:675-680.
21. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413:732-738.
22. Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem. 1999;274:10689-106892.
23. Kawasaki K, Akashi S, Shimazu R, Yoshida T, Miyake K, Nishijima M. Mouse toll-like receptor 4. MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J Biol Chem. 2000;275:2251-2254.
24. Hemmi H, Takeuchi O, Kawai T, et al. A toll-like receptor recognizes bacterial DNA. Nature. 2000;408:740-745.
25. Khatri S, Lass JH, Heinzel FP, et al. Regulation of endotoxin-induced keratitis by PECAM-1, MIP-2, and toll-like receptor 4. Invest Ophthalmol Vis Sci. 2002;43:2278-2284.
26. Saint Andre A, Blackwell NM, Hall LR, et al. The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness. Science. 2002;295:1892-1895.
27. Song PI, Abraham TA, Park Y, et al. The expression of functional LPS receptor proteins CD14 and toll-like receptor 4 in human corneal cells. Invest Ophthalmol Vis Sci. 2001;42:2867-2877.
28. Brett P, Mah D, Woods D. Isolation and characterization of Pseudomonas pseudomallei flagellin proteins. Infect Immun. 1994;62:1914-1919.
29. Rudner XL, Berk RS, Hazlett LD. Immunization with homologous Pseudomonas aeruginosa pili protects against ocular disease. Reg Immunol. 1993;5:245-252.
30. Rheinwald JG, Hahn WC, Ramsey MR, et al. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol. 2002;22:5157-5172.
31. Garrett ES, Perlegas D, Wozniak DJ. Negative control of flagellum synthesis in Pseudomonas aeruginosa is modulated by the alternative sigma factor AlgT (AlgU). J Bacteriol. 1999;181:7401-7404.
32. Yi X, Wang Y, Yu FS. Corneal epithelial tight junctions and their response to lipopolysaccharide challenge. Invest Ophthalmol Vis Sci. 2000;41:4093-4100.
33. Samatey FA, Imada K, Nagashima S, et al. Structure of the bacterial flagellar protofilament and implications for a switch for supercoiling. Nature. 2001;410:331-337.
34. Donnelly MA, Steiner TS. Two nonadjacent regions in enteroaggregative Escherichia coli flagellin are required for activation of toll-like receptor 5. J Biol Chem. 2002;277:40456-40461.
35. Gomez-Gomez L, Bauer Z, Boller T. Both the extracellular leucinerich repeat domain and the kinase activity of FSL2 are required for flagellin binding and signaling in Arabidopsis. Plant Cell. 2001;13:1155-1163.
36. Cole N, Krockenberger M, Bao S, Beagley KW, Husband AJ, Willcox M. Effects of exogenous interleukin-6 during Pseudomonas aeruginosa corneal infection. Infect Immun. 2001;69:4116-4119.
37. Hobden JA, Masinick SA, Barrett RP, Hazlett LD. Proinflammatory cytokine deficiency and pathogenesis of Pseudomonas aeruginosa keratitis in aged mice. Infect Immun. 1997;65:2754-2758.
38. Rosenbaum J, Planck S, Huang X, Rich L, Ansel J. Detection of mRNA for the cytokines, interleukin-1 alpha and interleukin-8, in corneas from patients with pseudophakic bullous keratopathy. Invest Ophthalmol Vis Sci. 1995;36:2151-2155.
39. Williams JM, Fini ME, Cousins SW, Repose JS. Corneal responses to infection. In: Krachmer JH, Mannis MJ, Holland EJ, eds. Cornea. St. Louis: Mosby; 1997;128-162.
40. Gipson I, Sugrue S. Cell biology of the corneal epithelium. In: Albert D, Jakobiec F, eds. Principles and Practice of Ophthalmology. Philadelphia: WB Saunders; 1994;3-16.
41. Stapleton F, Dart JK, Seal DV, Matheson M. 1995 Epidemiology of Pseudomonas aeruginosa keratitis in contact lens wearers. Epidemiol Infect. 114:395-402.
42. Schein OD, Glynn RJ, Poggio EC, Seddon JM, Kenyon KR. The relative risk of ulcerative keratitis among users of daily-wear and extended-wear soft contact lenses a case-control study. N Engl J Med. 1989;321:773-778.
43. Cario E, Podolsky DK. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun. 2000;68:7010-7017.
44. Laibson PR. Cornea and sclera. Arch Ophthalmol. 1972;88:553-574.