Synthesis and enzymic hydrolysis of oligoribonucleotides incorporating 3-deazaguanosine: The importance of the nitrogen-3 atom of single conserved guanosine residues on the catalytic activity of the hammerhead ribozyme

Helvetica Chimica Acta

Volumn 86, Issue 8, 2003, Pages 2726-2740

  Seela, Frank ^a   Debelak, Harald ^a   Andrews, Lori ^b   Beigelman, Leonid ^b  

^a UNIVERSITY OF OSNABRÜCK   (Germany)

^b Sirna Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; ENZYMES; HYDROLYSIS; REACTION KINETICS; SYNTHESIS (CHEMICAL);

SOLID PHASE SYNTHESIS;

PROTEINS;

3 DEAZAGUANOSINE; AMINO ACID; BASE; GUANOSINE DERIVATIVE; NITROGEN; NUCLEIC ACID BASE; OLIGORIBONUCLEOTIDE; PHOSPHORAMIDIC ACID; RIBOZYME; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SYNTHESIS; HYDROLYSIS; KINETICS; PRIORITY JOURNAL; SOLID STATE;

EID: 0141648532     PISSN: 0018019X     EISSN: None     Source Type: Journal    
DOI: 10.1002/hlca.200390222     Document Type: Article

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