Chemically modified hammerhead ribozymes with improved catalytic rates

Biochemistry

Volumn 35, Issue 45, 1996, Pages 14090-14097

  Burgin Jr , Alex B ^a   Gonzalez, Carolyn ^a   Matulic Adamic, Jasenka ^a   Karpeisky, Alexander M ^a   Usman, Nassim ^a   McSwiggen, James A ^a   Beigelman, Leonid ^a  

^a Sirna Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOZYME;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

CATALYSIS; HYDROGEN BONDING; KINETICS; NUCLEIC ACID CONFORMATION; PYRIDONES; RNA, CATALYTIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 10544238475     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961264u     Document Type: Article

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