Role and mechanisms of secondary mitochondrial failure

Acta Neurochirurgica, Supplement

Volumn 1999, Issue SUPPL. 73, 1999, Pages 7-13

  Siesjö, Bo K ^a   Elmer E ^a   Janelidze, S ^a   Keep, M ^a   Kristian T ^a   Ouyang, Y B ^a   Uchino, H ^a  

^a QUEEN S MEDICAL CENTER   (United States)

Author keywords

Cyclosporin A; FK506; Ischemia; Mitochondrial permeability transition (MPT); PBN

Indexed keywords

ANIMAL; BRAIN ISCHEMIA; CELL DEATH; FOREBRAIN; MITOCHONDRION; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; TIME; TRANSIENT ISCHEMIC ATTACK; VASCULARIZATION;

ANIMALS; BRAIN ISCHEMIA; CELL DEATH; ISCHEMIC ATTACK, TRANSIENT; MITOCHONDRIA; PROSENCEPHALON; TIME FACTORS;

EID: 0032619360     PISSN: 00651419     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6391-7_2     Document Type: Article

References (78)

1. Almeida A, Allen KL, Bates TE, Clark JB (1995) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. J Neurochem 65: 1698-1703
2. Ankarcrona M, Dypbukt JM, Bonfoco F., Zhivotovsky B, Orrenius S, Lipton S, Nicotera P (1995) Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15: 961-973
3. Bernardi P (1996) The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death. Biochim Biophys Acta 1275: 5-9
4. Bernardi P, Petronilli V (1996) The permeability transition pore as a mitodiondrial calcium release channel: a critical appraisal. J Bioenerg Biomembr 28: 131-138
5. Bonfoco E, Kraine D, Ankarcrona M, Nicotera P, Lipton SA (1995) Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92: 7162-7166
6. Butcher SP, Henshall DC, Teramura Y, Iwasaki K, Sharkey J (1997) Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism. J Neurosci 17: 6939-6946
7. Choi DW (1988) Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci 11: 465-469
8. Crompton M, Andreeva L (1993) On the involvement of a mitochondrial pore in reperfusion injury. Basic Res Cardiol 88: 513-23
9. 2+ uniporter. Biochem J 302: 181-185
10. Dawson VL, Dawson TM (1996) Nitric oxide actions in neurochemistry. Neurochem Int 29: 97-110
11. Deshpande JK, Siesjö BK, Wieloch T (1987) Calcium accumulation and neuronal damage in the rat hippocampus following cerebral ischemia. J Cereb Blood Flow Metab 7: 89-95
12. Drake M, Friberg H, Boris-Möller F, Sakata K, Wieloch T (1996) The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain. Acta Physiol Scand 158: 155-159
13. Endres M, Wang ZQ, Namura S, Waeber C, Moskowitz MA (1997)Ischemic brain injury is mediated by the activation of poly (ADP-ribose) polymerase. J Cereb Blood Flow Metab 17: 1143-1151
14. Erecinska M, Silver I (1994) Ions and energy in mammalian brain. Prog Neurobiol 43: 37-71
15. Estevez AG, Spear N, Manuel SM, Radi R, Henderson CE, Barbeito L, Beckman JS (1998) Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation. J Neurosci 18: 923-931
16. Folbergrová J, Zhao Q, Katsura K, Siesjö BK (1995) N-tertbutyl-α-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. Proc Natl Acad Sci USA 92: 5057-5061
17. Garcia JH, Liu KF, Relton JK (1995) Interleukin-1 receptor antagonist decreases the number of necrotic neurons in rats with middle cerebral artery occlusion. Am J Pathol 147: 1477-1486
18. Griffiths EJ, Halestrap AP (1991) Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin. Biochem J 274: 611-614
19. Hansen AJ (1985) Effect of anoxia on ion distribution in the brain. Physiol Rev 65: 101-148
20. Hara H, Friedlander RM, Gagliardini V, Ayata C, Fink K, Huang Z, Shimizu-Sasamata M, Yuan J, Moskowitz MA (1997) Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc Natl Acad Sci USA 94: 2007-2012
21. Henke W, Jung K (1993) Comparison of the effects of the immunosuppressive agents FK506 and cyclosporin A on rat kidney mitochondria. Biochem Pharmacol 46: 829-832
22. Hillered L, Siesjö BK, Arfors KE (1984) Mitochondrial response to transient forebrain ischemia and recirculation in the rat. J Cereb Blood Flow Metab 4: 438-446
23. Hillered L, Smith M-L, Siesjö BK (1985) Lactic acidosis and recovery of mitochondrial function following forebrain ischemia in the rat. J Cereb Blood Flow Metab 5: 259-266
24. Hirsch T, Marzo I, Kroemer G (1997) Role of the mitochondrial permeability transition pore in apoptosis. Biosci Rep 17: 67-76
25. Iadecola C, Zhang F, Xu X (1995) Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am J Physiol 268: R286-292
26. 2+-requiring, cyclosporin-sensitive pathway. Biochem Biophys Res Commun 161: 619-625
27. Kamiike W, Fujikawa M, Koseki M, Sumimura J, Miyata M, Kawashima Y, Wada H, Tagawa K (1989) Different patterns of leakage of cytosolic and mitochondrial enzymes. Clin Chim Acta 185: 265-270
28. Kantrow SP, Piantadosi CA (1997) Release of cytochrome c from liver mitochondria during permeability transition. Biochem Biophys Res Commun 232: 669-671
29. Kirino T (1982) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 239: 57-69
30. Kristián T, Siesjö BK (1997) Changes in ionic fluxes during cerebral ischaemia. Int Rev Neurobiol 40: 27-45
31. Kuroda S, Katsura K, Hillered L, Bates TE, Siesjö BK (1996) Delayed treatment with α-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiol Dis 3: 149-157
32. Kuroda S, Katsura KI, Tsuchidate R, Sicsjö BK (1996) Secondary bioenergetic failure after transient focal ischaemia is due to mitochondrial injury. Acta Physiol Scand 156: 149-150
33. Kuroda S, Siesjö B (1996) Postischemic administration of FK506 reduces infarct volume following transient focal brain ischemia. Neurosci Res Comm 19: 83-90
34. Kuroda S, Siesjö BK (1997) Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows. Clin Neurosci 4: 199-212
35. Kurokawa T, Kobayashi H, Nonami T, Harada A, Nakao A, Sugiyama S, Ozawa T, Takagi H (1992) Beneficial effects of cyclosporine on postischemic liver injury in rats. Transplantation 53: 308-311
36. Li P-A, Vogel J, Smith M-L, Kuschinsky W, Siesjö BK (1998) Brain damage due to transient forebrain ischemia in hyperglycemic rats is not due to capillary plugging. Brain Res (in press)
37. Marchetti P, Hirsch T, Zamzami N, Castedo M, Decaudin D, Susin SA, Masse B, Krocmer G (1996) Mitochondrial permeability transition triggers lymphocyte apoptosis. J Immunol 157: 4830-4836
38. Morley P, Hogan MJ, Hakim AM (1994) Calcium-mediated mechanisms of ischemic injury and protection. Brain Pathol 4: 37-47
39. Moskowitz MA, Dalkara T (1996) Nitric oxide and cerebral ischemia. Adv Neurol 71: 365-367; discussion 367-369
40. Murphy AN, Bredesen DE, Cortopassi G, Wang E, Fiskum G (1996) Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc Natl Acad Sci USA 93: 9893-9898
41. Nakai A, Kuroda S, Kristián T, Siesjö BK (1997) The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat. Neurobiol Dis 4: 288-300
42. Ouyang YB, Kuroda S, Kristián T, Siesjö BK (1997) Release of mitochondrial aspartate aminotransferase (mAST) following transient local cerebral ischemia suggests the opening of a mitochondrial permeability transition pore. Neurosci Res Comm 20: 167-173
43. Packer MA, Murphy MP (1994) Peroxynitrite causes calcium efflux from mitochondria which is prevented by cyclosporin A. FEBS Lett 345: 237-240
44. Packer MA, Murphy MP (1995) Peroxynitrite formed by simultaneous nitric oxide and superoxide generation causes cyclosporin A-sensitive mitochondrial calcium efflux and depolarisation. Eur J Biochem 234: 231-239
45. Pelekanou V, Trezise AE, Moore AL, Kay JE (1991) FK506 and rapamycin do not affect platelet aggregation or mitochondrial function. Transplant Proc 2.3: 3200-3201
46. Pelligrino DA (1993) Saying NO to cerebral ischemia [editorial]. J Neurosurg Anesthesiol 5: 221-231
47. Pulsinelli WA, Brierley JB, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11: 491-498
48. Pulsinelli WA, Duffy TE (1983) Regional energy balance in rat brain after transient forebrain ischemia. J Neurochem 40: 1500 1503
49. Rehnerona S, Mela L, Siesjö BK (1979) Recovery of brain mitochondrial function in the rat after complete and incomplete cerebral ischemia. Stroke 10: 437-446
50. Rothwell NJ, Strijbos PJ (1995) Cytokines in neurodegeneration and repair. Int J Dev Neurosci 13: 179-185
51. Sharkey J, Butcher SP (1994) Immunophilins mediate the neuroprotective effects of FK506 in local cerebral ischemia. Nature 371: 336-339
52. Shimizu S, Kamiike W, Hatanaka N, Nishimura M, Miyata M, Inoue T, Yoshida Y, Tagawa K, Matsuda H (1994) Enzyme release from mitochondria during reoxygenation of rat liver. Transplantation 57: 144-148
53. Siesjö B (1991) The role of calcium in cell death. In: Price D, Aguayo A, Thoenen H (eds) Neurodegenerative disorders: Mechanisms and prospects for therapy. John Wiley & Sons Ltd, Chichester
54. Siesjö BK (1988) Historical overview. Calcium, ischemia, and death of brain cells. Ann NY Acad Sci 522: 638-661
55. Siesjö BK (1990) Calcium, excitotoxins, and brain damage. News Physiol Sci 5: 120-125
56. Siesjö BK (1992) Pathophysiology and treatment of focal cerebral ischemia. I. Pathophysiology. J Neurosurg 77: 169-184
57. Siesjö BK (1992) Pathophysiology and treatment of focal cerebral ischemia. II. Mechanisms of damage and treatment. J Neurosurg 77: 337-354
58. Siesjö BK, Kristián T, Katsura K (1995) The role of calcium in delayed postischemic brain damage. In: Moskowitz M, Caplan LR (eds) Cerebrovascular diseases, 19th Princeton Stroke Conference. Butterworth-Heinemann, Boston
59. Siesjö BK, Siesjö P (1996) Mechanisms of secondary brain injury. Eur J Anaesthesiol 13: 247-268
60. Sims NR (1991) Selective impairment of respiration in mitochondria isolated from brain subrogions following transient forebrain ischemia in the rat. J Neurochem 56: 1836-1844
61. Sims NR, Pulsinelli WA (1987) Altered mitochondrial respiration in selectively vulnerable brain subregions following transient forebrain ischemia in the rat. J Neurochem 49: 1367-1374
62. Susin SA, Zamzami N, Castedo M, Daugas F., Wang HG, Geley S, Fassy F, Reed JC, Kroemer G (1997) The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95-and ceramide-induced apoptosis. J Exp Med 186: 25-37
63. Susin SA, Zamzami N, Castedo M, Hirsch T, Marchetti P, Macho A, Daugas E, Geuskens M, Kroemer G (1996) Bcl-2 inhibits the mitochondrial release of an apoplogenic protease. J Exp Med 184: 1331-1341
64. Takahashi K, Greenberg JH, Jackson P, Maclin K, Zhang J (1997) Neuroprotective effects of inhibiting poly(ADP-ribose) synthetase on focal cerebral ischemia in rats. J Cereb Blood Flow Metab 17: 1137-1142
65. Tsuchidate R, He Q-P, Smith M-L, Siesjö BK (1997) Regional cerebral blood flow during and after 2 hours of middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 17: 1066-1073
66. Tymianski M, Tator CH (1996) Normal and abnormal calcium homcostasis in neurons: a basis for the pathophysiology of traumatic and ischemic central nervous system injury. Neurosurgery 38: 1176-1195
67. Uchino H, Elmer, Uchino K, Smith M-I., Siesjö BK (1998) Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat. Brain Res (in press)
68. Uchino H, Elmer E, Uchino K, Lindvall O, Siesjö BK (1995) Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat. Acta Physiol Scand 155: 469-471
69. Wagner KR, Kleinholz M, de Courten-Myers GM, Myers RE (1992) Hyperglycemic versus normoglycemic stroke: topography of brain metabolites, intracellular pH, and infarct size. J Cereb Blood Flow Metab 12: 213-222
70. Wagner KR, Kleinholz M, Myers RF, (1990) Delayed decreases in specific brain mitochondrial electron transfer complex activities and cytochrome concentrations following anoxia/ischemia. J Neurol Sci 100: 142-151
71. Wagner KR, Kleinholz M, Myers RE (1990) Delayed onset of neurologic deterioration following anoxia/ischemia coincides with appearance of impaired brain mitochondrial respiration and decreased cytochrome oxidase activity. J Cereb Blood How Metab 10: 417-423
72. Zaidan E, Sheu KF, Sims NR (1998) The pyruvate dehydrogenase complex is partially inactivated during early recirculation following short-term forebrain ischemia in rats. J Neurochem 70: 233-241
73. Zaidan E, Sims NR (1994) The calcium content of mitochondria from brain subregions following short-term forebrain ischemia and recirculation in the rat. J Neurochem 63: 1812-1819
74. Zamzami N, Hirsch T, Dallaporta B, Petit PX, Kroemer G (1997) Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis. J Bioenerg Biomemb 29: 185-193
75. Zamzami N, Marchetti P, Castedo M, Hirsch T, Susin SA, Masse B, Kroemer G (1996) Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrance potential during apoptosis. FEBS Lett 384: 53-57
76. Zamzami N, Susin SA, Marehetti P, Hirsch T, Gomez-Monterrey I, Castedo M, Kroemer G (1996) Mitochondrial control of nuclear apoptosis. J Exp Med 183: 1533-1544
77. Zhao Q, Pahlmark K, Smith M-L, Siesjö BK (1994) Delayed treatment with the spin trap α-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rals. Acta Physiol Scand 152: 349-350
78. Zoratti M, Szabo I (1995) The mitochondrial permeability transition. Biochim Biophys Acta 1241: 139-176