Trefoil factor-2 is an allergen-induced gene regulated by Th2 cytokines and STAT6 in the lung

American Journal of Respiratory Cell and Molecular Biology

Volumn 29, Issue 4, 2003, Pages 458-464

  Nikolaidis, Nikolaos M ^b   Zimmermann, Nives ^b   King, Nina E ^b   Mishra, Anil ^b   Pope, Samuel M ^b   Finkelman, Fred D ^b   Rothenberg, Marc E ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CYTOKINE; FUNGUS ANTIGEN; INTERLEUKIN 13; INTERLEUKIN 4; OVALBUMIN; STAT6 PROTEIN; TREFOIL PEPTIDE;

ACUTE DISEASE; ALLERGIC REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPERGILLUS FUMIGATUS; ASTHMA; CHRONICITY; CONTROLLED STUDY; GASTROINTESTINAL MUCOSA; GASTROINTESTINAL SECRETION; GENE CONTROL; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; IMMUNE RESPONSE; IMMUNE RESPONSE GENE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; TH2 CELL; TREFOIL FACTOR 2 GENE; UPREGULATION; WOUND HEALING;

ALLERGENS; ANIMALS; ASPERGILLUS FUMIGATUS; ASTHMA; BRONCHI; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; INTERLEUKIN-13; INTERLEUKIN-4; LUNG; MICE; MICE, INBRED BALB C; MUCINS; MUSCLE PROTEINS; NEUROPEPTIDES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVALBUMIN; PEPTIDES; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR; TH2 CELLS; TRANS-ACTIVATORS;

ANIMALIA; ASPERGILLUS; ASPERGILLUS FUMIGATUS; FUNGI; LOTUS;

EID: 0141526109     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2002-0309OC     Document Type: Article

References (45)

1. ISAAC. 1998. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 351:1225-1232.
2. Broide, D. H. 2001. Molecular and cellular mechanisms of allergic disease. J. Allergy Clin. Immunol. 108:S65-S71.
3. Busse, W. W., and R. F. Lemanske, Jr. 2001. Asthma. N. Engl. J. Med. 344:350-362.
4. Lee, N. A., E. W. Gelfand, and J. J. Lee. 2001. Pulmonary T cells and eosinophils: coconspirators or independent triggers of allergic respiratory pathology? J. Allergy Clin. Immunol. 107:945-957.
5. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. M. Bentley, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298-304.
6. Hogan, S. P., K. I. Matthaei, J. M. Young, A. Koskinen, I. G. Young, and P. S. Foster. 1998. A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5. J. Immunol. 161:1501-1509.
7. Drazen, J. M., J. P. Arm, and K. F. Austen. 1996. Sorting out the cytokines of asthma. J. Exp. Med. 183:1-5.
8. Ray, A., and L. Cohn. 1999. Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation. J. Clin. Invest. 104:985-993.
9. Wills-Karp, M. 1999. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17:255-281.
10. Bochner, B. S., B. J. Undem, and L. M. Lichtenstein. 1994. Immunological aspects of allergic asthma. Annu. Rev. Immunol. 12:295-335.
11. Holgate, S. T., D. E. Davies, P. M. Lackie, S. J. Wilson, S. M. Puddicombe, and J. L. Lordan. 2000. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J. Allergy Clin. Immunol. 105:193-204.
12. Boushey, H. A., Jr. 2001. Experiences with monoclonal antibody therapy for allergic asthma. J. Allergy Clin. Immunol. 108:S77-S83.
13. Barnes, P. J. 2000. New directions in allergic diseases: mechanism-based anti-inflammatory therapies. J. Allergy Clin. Immunol. 106:5-16.
14. Zimmermann, N., N. E. King, J. Laporte, M. Yang, A. Mishra, S. M. Pope, E. E. Muntel, D. P. Witte, A. E. Pegg, P. S. Foster, Q. Hamid, and M. E. Rothenberg. 2003. Dissection of experimental asthma with DNA microarray analysis: identification of arginase in asthma pathogenesis. J. Clin. Invest. 111:1863-1874.
15. Thim, L. 1997. Trefoil peptides: from structure to function. Cell. Mol. Life Sci. 53:888-903.
16. Podolsky, D. K. 2000. Mechanisms of regulatory peptide action in the gastrointestinal tract: trefoil peptides. J. Gastroenterol. 35:69-74.
17. Farrell, J. J., D. Taupin, T. J. Koh, D. Chen, C. M. Zhao, D. K. Podolsky, and T. C. Wang. 2002. TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury. J. Clin. Invest. 109:193-204.
18. Thim, L., F. Madsen, and S. S. Poulsen. 2002. Effect of trefoil factors on the viscoelastic properties of mucus gels. Eur. J. Clin. Invest. 32:519-527.
19. Mishra, A.,T. E. Weaver, D. C. Beck, and M. E. Rothenberg. 2001. Interleukin-5-mediated allergic airway inflammation inhibits the human surfactant protein C promoter in transgenic mice. J. Biol. Chem. 276:8453-8459.
20. Finkelman, F. D., K. B. Madden, S. C. Morris, J. M. Holmes, N. Boiani, I. M. Katona, and C. R. Maliszewski. 1993. Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. J. Immunol. 151:1235-1244.
21. Rankin, J. A., D. E. Picarella, G. P. Geba, U.-A. Temann, B. Prasad, B. DiCosmo, A. Tarallo, B. Stripp, J. Whitsett, and R. A. Flavell. 1996. Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc. Natl. Acad. Sci. USA 93:7821-7825.
22. Shimoda, K., J. van Deursen, M. Y. Sangster, S. R. Sarawar, R. T. Carson, R. A. Tripp, C. Chu, F. W. Quelle, T. Nosaka, D. A. Vignali, P. C. Doherty, G. Grosveld, W. E. Paul, and J. N. Ihle. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380:630-633.
23. Pope, S. M., E. B. Brandt, A. Mishra, S. P. Hogan, N. Zimmermann, K. I. Matthaei, P. S. Foster, and M. E. Rothenberg. 2001. IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism. J. Allergy Clin. Immunol. 108:594-601.
24. Zimmermann, N., S. P. Hogan, A. Mishra, E. B. Brandt, T. R. Bodette, S. M. Pope, F. D. Finkelman, and M. E. Rothenberg. 2000. Murine eotaxin-2: A constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression. J. Immunol. 165:5839-5846.
25. Kurup, V. P., S. Mauze, H. Choi, B. W. Seymour, and R. L. Coffman. 1992. A murine model of allergic bronchopulmonary aspergillosis with elevated eosinophils and IgE. J. Immunol. 148:3783-3788.
26. Kurup, V. P., H. Choi, P. S. Murali, and R. L. Coffman. 1994. IgE and eosinophil regulation in a murine model of allergic aspergillosis. J. Leukoc. Biol. 56:593-598.
27. Wills-Karp, M. 2001. IL-12/IL-13 axis in allergic asthma. J. Allergy Clin. Immunol. 107:9-18.
28. Hamelmann, E., J. Schwarze, K. Takeda, A. Oshiba, G. L. Larsen, C. G. Irvin, and E. W. Gelfand. 1997. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am. J. Respir. Crit. Care Med. 156:766-775.
29. Foster, P. S., A. W. Mould, M. Yang, J. Mackenzie, J. Mattes, S. P. Hogan, S. Mahalingam, A. N. McKenzie, M. E. Rothenberg, I. G. Young, K. I. Matthaei, and D. C. Webb. 2001. Elemental signals regulating eosinophil accumulation in the lung. Immunol. Rev. 179:173-181.
30. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of Stat6 in IL-4 signaling. Nature 380:627-630.
31. Ihle, J. N. 2001. The Stat family in cytokine signaling. Curr. Opin. Cell Biol. 13:211-307.
32. Ribieras, S., O. Lefebvre, C. Tomasetto, and M. C. Rio. 2001. Mouse Trefoil factor genes: genomic organization, sequences and methylation analyses. Gene 266:67-75.
33. Al-azzeh, E. D., P. Fegert, N. Blin, and P. Gott. 2000. Transcription factor GATA-6 activates expression of gastroprotective trefoil genes TFF1 and TFF2. Biochim. Biophys. Acta 1490:324-332.
34. Bulitta, C. J., J. V. Fleming, R. Raychowdhury, D. Taupin, I. Rosenberg, and T. C. Wang. 2002. Autoinduction of the trefoil factor 2 (TFF2) promoter requires an upstream cis-acting element. Biochem. Biophys. Res. Commun. 293:366-374.
35. Kuperman, D. A., X. Huang, L. L. Koth, G. H. Chang, G. M. Dolganov, Z. Zhu, J. A. Elias, D. Sheppard, and D. J. Erle. 2002. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat. Med. 8:885-889.
36. Blease, K., J. M. Schuh, C. Jakubzick, N. W. Lukacs, S. L. Kunkel, B. H. Joshi, R. K. Puri, M. H. Kaplan, and C. M. Hogaboam. 2002. Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma. Am. J. Pathol. 160:481-490.
37. Trifilieff, A., A. El-Hasim, R. Corteling, and C. E. Owen. 2000. Abrogation of lung inflammation in sensitized Stat6-deficient mice is dependent on the allergen inhalation procedure. Br. J. Pharmacol. 130:1581-1588.
38. Rio, M. C., M. P. Chenard, C. Wolf, L. Marcellin, C. Tomasetto, R. Lathe, J. P. Bellocq, and P. Chambon. 1991. Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract. Gastroenterology 100:375-379.
39. Wright, N. A., R. Poulsom, G. W. Stamp, P. A. Hall, R. E. Jeffery, J. M. Longcroft, M. C. Rio, C. Tomasetto, and P. Chambon. 1990. Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues. J. Pathol. 162:279-284.
40. Alison, M. R., R. Chinery, R. Poulsom, P. Ashwood, J. M. Longcroft, and N. A. Wright. 1995. Experimental ulceration leads to sequential expression of spasmolytic polypeptide, intestinal trefoil factor, epidermal growth factor and transforming growth factor alpha mRNAs in rat stomach. J. Pathol. 175:405-414.
41. Holgate, S. T., P. M. Lackie, D. E. Davies, W. R. Roche, and A. F. Walls. 1999. The bronchial epithelium as a key regulator of airway inflammation and remodelling in asthma. Clin. Exp. Allergy 29:90-95.
42. Vignola, A. M., G. Chiappara, L. Siena, A. Bruno, R. Gagliardo, A. M. Merendino, B. S. Polla, A. P. Arrigo, G. Bonsignore, J. Bousquet, and P. Chanez. 2001. Proliferation and activation of bronchial epithelial cells in corticosteroid-dependent asthma. J. Allergy Clin. Immunol. 108:738-746.
43. Hastie, A. T., W. K. Kraft, K. B. Nyce, J. G. Zangrilli, A. I. Musani, J. E. Fish, and S. P. Peters. 2002. Asthmatic epithelial cell proliferation and stimulation of collagen production: human asthmatic epithelial cells stimulate collagen type III production by human lung myofibroblasts after segmental allergen challenge. Am. J. Respir. Crit. Care Med. 165:266-272.
44. Konturek, P. C., T. Brzozowski, S. J. Konturek, G. Elia, N. Wright, Z. Sliwowski, L. Thim, and E. G. Hahn. 1997. Role of spasmolytic polypeptide in healing of stress-induced gastric lesions in rats. Regul. Pept. 68:71-79.
45. Hunt, J. F., K. Fang, R. Malik, A. Snyder, N. Malhotra, T. A. Platts-Mills, and B. Gaston. 2000. Endogenous airway acidification. Implications for asthma pathophysiology. Am. J. Respir. Crit. Care Med. 161:694-699.