The bronchial epithelium as a key regulator of airway inflammation and remodelling in asthma

Clinical and Experimental Allergy, Supplement

Volumn 29, Issue 2, 1999, Pages 90-95

  Holgate, S T ^a,b   Lackie, P M ^a   Davies, D E ^a   Roche, W R ^a   Walls, A F ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Asthma; Epidermal growth factor receptors; Epithelium; Myofibroblasts; Remodelling

Indexed keywords

CELL ADHESION MOLECULE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR;

ALLERGIC ASTHMA; BRONCHUS HYPERREACTIVITY; BRONCHUS MUCOSA; CONFERENCE PAPER; ENZYME RELEASE; EOSINOPHIL; HUMAN; MAST CELL; MEDIATOR RELEASE; MYOFIBROBLAST; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; T LYMPHOCYTE;

ANIMALS; ASTHMA; BRONCHI; BRONCHITIS; CELL ADHESION MOLECULES; ENDOPEPTIDASES; EPITHELIUM; HUMANS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 0033011603     PISSN: 09602178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (62)

1. International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis and atopic eczema: ISAAC. Lancet 1998; 351:1225-32.
2. van der Veen JM, Lapuhaä CE, Aalberse RC, Jansen HM, van der Zee JS. Bronchial challenge with isolated major allergens of Dermatophagoides pteronyssinus. The role of patient characteristics in the early asthmatic response. J Allergy Clin Immunol 1998; 102:24-31.
3. Redington AE, Simes PJ, Howart PH, Holgate ST. Fibroblasts and extracellular matrix in asthma. In: Holgate ST, Busse WW (eds). Inflammatory Mechanisms in Asthma. Lung biology in health and disease. Lenfant C (Exec, eds), Vol. 117, New York: Marcel Dekker, 1998:443-67.
4. Phunek P, Roche WR, Turzikova J, Kurdmann J, Warner JO. Eosinophilic inflammation in the bronchial mucosa of children with bronchial asthma. Eur Respir J 1997; 19 (Suppl.25):160s (abstract).
5. Montefort S, Baker J, Roche WR, Holgate ST. The distribution of adhesive mechanisims in the normal bronchial epithelium. Eur Resp J 1992; 6:1257-63.
6. Montefort S, Roberts JA, Beasley CR, Holgate ST, Roche WR. The site of disruption of the bronchial epithelium in asthmatics and non-asthmatics. Thorax 1992; 47:499-503.
7. Lackie PM, Baker JE, Günthert U, Holgate ST. Expression of CD44 isoforms is increased in the airway epithelium of asthmatic subjects. Am J Resp Cell Mol Biol 1997; 16:14-22.
8. Knobil K, Jacoby DB. Mediator functions of epithelial cells. In: Holgate ST, Busse WW (eds). Inflammatory Mechanisms in Asthma. Lung biology in health and disease. Lenfant C (Exec, eds), Vol. 117, New York: Marcel Dekker, 1998:469-95.
9. Zhang S, Smartt H, Holgate ST, Roche WR. Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co-culture model of airway remodelling in asthma. Lab Invest 1998 (in press).
10. Walls AF, Shute JK, Warner J et al. Mast cell and eosinophil proteases in the chronic allergic inflammatory response. In: Marone G, Austen KF, Lichtenstein L, Kay AB, Holgate ST (eds). Asthma, Physiology, Immunopharmacology and Treatment. San Diego: Academic Press, 1998:119-31.
11. Pereira PJB, Bergner A, Macedo-Ribeiro S et al. Human J-tryptase is a ring-like tetramer with active sites facing a central pore. Nature 1998; 392:306-10.
12. Wenzel SE, Fowler AA, Schwartz LB. Activation of pulmonary mast cells by bronchoalveolar challenge. In vivo release of histamine and tryptase in atopic subjects with and without asthma. Am Rev Respir Dis 1988; 137:1002-8.
13. Molinari JF, Scari M, Moore WR et al. Inhaled tryptase causes bronchoconstriction in sheep via histamine release. Am J Respir Crit Care Med 1996; 154:649-53.
14. He S, Walls AF. Human mast cell tryptase: a stimulus of microvascular leakage and mast cell activation. Eur J Pharmacol 1997a; 328:89-97.
15. He S, Walls AF. Potent induction of neutrophil and eosinophil-rich infiltrate in vivo by human mast cell tryptase. Selective enhancement of eosinophil recruitment by histamine. J Immunol 1997b; 159:6216-25.
16. Cairns JA, Walls AF. Mast cell tryptase is a mitogen for epithelial cells: stimulation of IL-8 production and ICAM-I expression. J Immunol 1996; 156:275-83.
17. Cairns JA, Walls AF. Mast cell tryptase stimulates the synthesis of type I collagen in human fibroblasts. J Clin Invest 1997; 99:1313-21.
18. Thabrew H, Cairns JA, Walls AF. Mast cell tryptase is a growth factor for airway smooth muscle. J Allergy Clin Immunol 1996; 97:969 (abstract).
19. Compton SJ, Cairns JA, Holgate ST, Walls AF. The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release and adhesion molecule expression. Tryptase induces expression of mRNA for IL-1β and IL-8 and stimulates selective release of IL-8 from HUVEC. J Immunol 1998; 186:1939-47.
20. Molino M, Barnathon ES, Numerof R et al. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem 1997; 272:4043-9.
21. Perng D-W, Holgate ST, Walls AF. Mast cell tryptase as a stimulus for cytokine production and release from epithelial cells: role of PAR-2. Immunol 1998; 95: (Suppl. 1):21(abstract).
22. Thompson PJ. Unique role of allergens and the epithelium in asthma. Clin Exp Allergy 1998; 28 (Suppl. 5) 110-18.
23. Shimizu T, Nishihara M, Kawaguchi S, Sakakura Y. Expression of phenotypic markers during regeneration of rat tracheal epithelium following mechanical injury. Am J Respir Cell Mol Biol 1994; 11:85-94.
24. Borland G, Ross JA, Guy K. Forms and functions of CD44. Immunol 1998; 93:139-48.
25. Weiss JM, Sleeman J, Renkl AC et al. An essential role for CD44 variant isoforms in epidermal Langerhans cell and blood dendritic cell function. J Cell Biol 1997; 137:1137-47.
26. Ito H, Yamauchi K, Inoue H, Rennard SI, Spurzem JR. CD44 and CD44-related chrondriotin sulphate proteoglycan mediate human bronchial epithelial cell migration. Am J Respir Crit Care Med 1997; 155:A179.
27. Leir S-H, Baker JE, Lackie PM. Cellular correlates of expression of CD44 and its variants in airway epithelial cells. J Appl Physiol 1999 (in press).
28. Tsukita S, Oishi K, Sato N, Sagara J, Kawai A. ERM family members as molecular linkers between the cell surface glycoprotien CD44 and actin-based cytoskeleton. J Cell Biol 1994; 126:391-401.
29. Jackson DG, Bell JI, Dickinson R, Timans J, Shields J. Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the V3 exon. J Cell Biol 1997; 128:673-85.
30. Bennett KL, Jackson DG, Simon JC et al. CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor. J Cell Biol 1995; 128:687-98.
31. Nagafuchi A, Ishihara S, Tsukita S. The roles of catenins in the cadherin-mediated cell adhesion: Functional analysis of E-cadherin-a catenin fusion molecules. J Cell Biol 1994; 127:235-45.
32. Horwitz A, Duggan K, Buck C, Beckerle MC, Burridg K. Interaction of plasma-membrane fibronectin receptor with talin - a transmembrane linkage. Nature 1986; 320:531-3.
33. Otey CA, Pavalko FM, Burridge K. An interaction between alpha-actinin and the beta-1 integrin subunit in vitro. J Cell Biol 1990; 111:721-9.
34. Bullock GR, Campbell AM, Warhol MJ, Multhaupt HAB, Bousquet J. Expression of E-cadherin and alpha, beta and gamma-catenin is associated with epithelial shedding in human lung and nose. J Allergy Clin Immunol 1998; 101:459.
35. Herard AL, Pierrot D, Hinnrasky J et al. Fibronectin and its alpha (5) beta (1)-integrin receptor are involved in the wound-repair process of airway epithelium. Am J Physiol 1996; 15:L726-L733.
36. Chen LL, Ferrando RE, Christian DL et al. Comparison of integrin expression in asthmatic versus normal bronchial epithelium. Am J Respir Crit Care Med 1996; 153:A646 (abstract).
37. Gumbiner B, Stevenson B, Grimaldi A. The role of the cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex. J Cell Biol 1988; 107:1575-87.
38. Zhu X, Huang XZ, Wu JF, Farese RV, Sheppard D. The integrin alpha V beta 6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin. Mol Biol Cell 1997; 8:1074.
39. Sonnenburg A, Calafat J, Junessen H et al. Integrin A6/B4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion. J Cell Biol 1991; 113:907-17.
40. Rahman I, MacNee W. Role of transcription factors in inflammatory lung disease. Thorax 1998; 53:601-2.
41. Rosette C, Karin M. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Sci 1996; 274:1194-7.
42. Huang RP, Wu JX, Fan Y, Adamson ED. UV activates growth factor receptors via reactive oxygen intermediates. J Cell Biol 1996; 133:211-20.
43. Polosa R, Krishna MT, Howarth P et al. Elevated epidermal growth factor receptor (EGFR) expression in bronchial epithelium of mild and severe asthmatics. Eur Respir J 1998; 12 (Suppl 28):265s (abstract).
44. Amishima M, Munakata M, Nasuhara Y et al. Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway. Am J Respir Crit Care Med 1998; 157:1907-12.
45. Puddicombe SM, Holgate ST, Davies DE. The role of the epidermal growth factor receptor (EGFR) in bronchial epithelial repair. Eur Respir J 1998 (abstract) (in press).
46. Richter A, Holgate ST, Davies DE. Involvement of the epidermal growth factor receptor (EGFR) in the response of bronchial epithelial cells to oxidant stress. Eur Respir J (abstract) (in press).
47. Antoniades HN, Galanopoulos T, Neville-Golden J, Kiritsy CP, Lynch SE. Expression of growth factor and receptor mRNAs in skin epithelial cells following acute cutaneous injury. Am J Pathol 1993; 142:1099-110.
48. Puddicombe SM, Holgate ST, Davies DE. Epidermal growth factor (EGF) promotes in vitro bronchial epithelial repair. British Association of Lung Research, Cardiff, Sept. 1998 (abstract).
49. Daub H, Weiss U, Wallasch C, Ullrich A. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 1996; 379:557-60.
50. Goishi K, Higashiyama S, Klagsbrun M et al. Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-Iike growth factor: conversion from juxtacrine to paracrine growth factor activity. Mol Biol Cell 1995; 6:967-80.
51. Arribas J, Coodly L, Vollmer P et al. Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprolease inhibitors. J Biol Chem 1996; 271:11376-82.
52. Suzuki M, Raab G, Moses MA, Fernandez CA, Klagsbrun M. Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage of a specific juxtamembrane site. J Biol Chem 1997; 272:31730-7.
53. Redington AE, Madden J, Frew AJ et al. Transforming growth factor-β in asthma. Measurement in bronchoalveolar fluid. Am J Respir Crit Care Med 1997; 156:642-7.
54. Redington AE, Roche WR, McFadden J et al. Basic fibroblast growth factor in asthma: immunolocalisation in bronchial biopsies and measurement in bronchoalveolar lavage at baseline and following allergen challenge. Am J Respir Crit Care Med 1999 (in press).
55. neu protein and EGF receptor modulates EGF receptor function. Cell 1990; 61:1339-47.
56. Fedi P, Pierce JH, Di Fiore PP, Kraus MH. Efficient coupling with PI-3-K, but not PLC-K or GAP, distinguishes erbB3 signalling from that of other ErbB/EGFR family members. Mol Cell Biol 1994; 14:492-500.
57. Pinkas-Kramarski R, Soussan L, Waterman H et al. Diversification of neu differentiation factor and epidermal growth factor signalling by combinatorial receptor interactions. EMBO J 1996; 15:2452-67.
58. Polosa R, Prosperini G, Leir S-H et al. Expression of c-erbB Receptors and Ligands in Human Bronchial Mucosa. Am J Resp Cell Mol Biol 1998 (in press).
59. Vignola AM, Chanez P, Chiappara G et al. Transforming growth factor-J expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 1997; 156:591-9.
60. Post M, Souza P, Ciu J et al. Keratinocyte growth and its receptor are involved in early lung branching. Dev 1996; 122:3107-15.
61. Finch PW, Cunha GR, Rubin JS, Wong J, Ron D. Pattern of keratinocyte growth factor and KGF receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchyme epithelial interactions. Dev Dyn 1995; 203:223-40.
62. Dube J, Chakir J, Laviolette M et al. In vitro procollagen synthesis and proliferative phenotype of bronchial fibroblasts from normal and asthmatic subjects. Lab Invest 1998; 78:297-307.