Analysis of Escherichia coli anaplerotic metabolism and its regulation mechanisms from the metabolic responses to altered dilution rates and phosphoenolpyruvate carboxykinase knockout

Biotechnology and Bioengineering

Volumn 84, Issue 2, 2003, Pages 129-144

  Yang, Chen ^a   Hua, Qianq ^a   Baba, Tomoya ^a   Mori, Hirotada ^a   Shimizu, Kazuyuki ^a,b  

^a KEIO UNIVERSITY   (Japan)

^b KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

13C labeling; Anaplerotic reaction; Escherichia coli; In vivo regulation; Metabolic flux; Phosphoenolpyruvate carboxykinase

Indexed keywords

CARBOXYLATION; ENZYMES; ESCHERICHIA COLI; METABOLISM;

ANAPLEROTIC FLUXES;

BIOTECHNOLOGY;

ADENOSINE TRIPHOSPHATE; AMINO ACID; CARBON 13; GLUCOSE; GLYCEROL; GLYOXYLIC ACID; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP);

ANAPLEROTIC METABOLISM; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL STRAIN; BACTERIUM CULTURE; CHEMOSTAT; DELETION MUTANT; ENERGY TRANSFER; ENZYME ACTIVITY; ESCHERICHIA COLI; GROWTH RATE; KNOCKOUT GENE; METABOLIC FLUX ANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PCK GENE; PROTON NUCLEAR MAGNETIC RESONANCE; REGULATORY MECHANISM;

ACETYL COENZYME A; ADENINE NUCLEOTIDES; ADENOSINE TRIPHOSPHATE; ALGORITHMS; AMINO ACIDS; CARBON; CARBON DIOXIDE; CARBON ISOTOPES; CARBOXYLIC ACIDS; CELL DIVISION; CITRIC ACID CYCLE; ENERGY METABOLISM; ESCHERICHIA COLI; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; GLYCOLYSIS; HYDROLYSIS; ISOCITRATE DEHYDROGENASE; ISOCITRATE LYASE; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, BIOLOGICAL; MONOSACCHARIDES; MUTATION; OXYGEN; PENTOSE PHOSPHATE PATHWAY; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); PHOSPHOENOLPYRUVATE CARBOXYLASE; SUBSTRATE CYCLING;

ESCHERICHIA COLI;

EID: 0141504947     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10692     Document Type: Article

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