Endogenous melanocortin antagonist in fish: Structure, brain mapping, and regulation by fasting of the goldfish agouti-related protein gene

Endocrinology

Volumn 144, Issue 10, 2003, Pages 4552-4561

  Cerdá Reverter, José Miguel ^a,b   Peter, Richard Ector ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CSIC Instituto de Acuicultura de Torre de la Sal IATS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MELANOCORTIN; PEPTIDE;

ARTICLE; BRAIN MAPPING; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; FISH; FOOD INTAKE; GENE OVEREXPRESSION; GENOME; GOLDFISH; HYPOTHALAMUS; IN SITU HYBRIDIZATION; MALE; MAMMAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; UPREGULATION;

ALPHA-MSH; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BRAIN; CLONING, MOLECULAR; ENERGY METABOLISM; FASTING; FEMALE; GENE EXPRESSION; GOLDFISH; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MOLECULAR SEQUENCE DATA; PROTEINS; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 0141450532     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0453     Document Type: Article

References (43)

1. Cone RD 1999 The central melanocortin system and energy homeostasis. Trends Endocrinol Metab 10:211-216
2. Wilson BD, Ollmann MM, Barsh GS 1999 The role of agouti-related protein in regulating body weight. Mol Med Today 5:250-256
3. Schiöth HB 2002 The physiological role of melanocortin receptors. Vitam Horm 63:195-232
4. Lu D, Willard D, Patel IR, Kadwell S, Overton L, Kost T, Luhter M, Chen W, Woychik RP, Wilkinson WO 1994 Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature 371:799-802
5. Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen I, Gantz I, Barsh GS 1997 Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278:135-138
6. Bultman SJ, Michaud EJ, Woychik RP 1992 Molecular characterization of the mouse agouti locus. Cell 71:1195-204
7. Manne J, Argeson AC, Siracusa LD 1995 Mechanism for the pleiotropic effects of the agouti gene. Proc Natl Acad Sci USA 92:4721-4724
8. Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, Rosemblum CI, Vongs A, Feng Y, Cao L, Metzger JM, Strack AM, Camacho RE, Mellin TN, Nunes CN, Min W, Fisher J, Gopal-Truter S, MacIntyre DE, Chen HY, Van der Ploeg LH 2000 Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26:97-102
9. y) is associated with the disruption of a novel RNA-binding protein. Genes Dev 7:1203-1213
10. Miller MW, Duhl DMJ, Vrieling H, Cordes SP, Ollmann MM, Winkes BN, Barsh GS 1993 Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 7:454-467
11. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F 1997 Targeted disruption of melanocortin-4 receptor results in obesity in mice. Cell 88:131-141
12. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD 1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165-168
13. Cone RD, Lu D, Koppula S, Vage DI, Klungland H, Boston B, Chen W, Orth DN, Pouton C, Kesterson RA 1996 The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res 51:287-317
14. Shutter JR, Gramham M, Kinsey AC, Scully S, Luthy R, Stark K 1997 Hypothalamic expression of ART, a novel gene related to agouti, is upregulated in obese and diabetic mutant mice. Genes Dev 11:593-602
15. McNulty JC, Thompson DA, Bolin KA, Wilken J, Barsh GS, Millhauser GL 2001 High-resolution NMR structure of the chemically synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein. Biochemistry 40:15520-15527
16. Takeuchi S, Teshigawara K, Takahashi S 2000 Widespread expression of Agouti-related protein (AGRP) in the chicken: a possible involvement of AGRP in regulating peripheral melanocortin systems in the chicken. Biochim Biophys Acta 1496:261-269
17. Hahn TM, Breininger JF, Baskin DG, Schwartz MW 1998 Coexpression of AGRP and NPY in fasting-activated hypothalamic neurons. Nat Neurosci 1:271-272
18. Bangol D, Lu X-Y, Kaelin CB, Day HEW, Ollmann M, Gantz I, Akil H, Barsh GS, Watson SJ 1999 Anatomy of an endogenous antagonist: Relationship between agouti-related protein and proopiomelanocortin in the brain. J Neurosci 19: RC26 1-7
19. Hagan MM, Rushing PA, Pritchard LM, Schwartz MW, Strack AM, Van der Ploeg LHT, Woods SC, Seeley RJ 2000 Long-term orexigenic effects of AgRP-(83-132) involve mechanism other than melanocortin receptor blockade. Am J Physiol 279:R47-R52
20. Small CJ, Kim MS, Stanley SA, Mitchell JRD, Murphy K, Morgan DGA, Ghatei MA, Bloom SR 2001 Effects of chronic central nervous system administration of agouti-related protein in pair-fed animals. Diabetes 50:248-254
21. Cerdá-Reverter JM, Ringholm A, Schiöth HB, Peter RE 2003 Molecular cloning, pharmacological characterization and brain mapping of the melanocortin 4 receptor in the goldfish: involvement in the control of food intake. Endocrinology 144:2336-2349
22. Cerdá-Reverter JM, Schiöth HB, Peter RE, The central melanocortin system regulates food intake in goldfish. Regul Pept, in press
23. H genes of the goldfish, Carassius auratus: a re-examination. Mol Immunol 28:449-457
24. Cerdá-Reverter JM, Martínez-Rodríguez G, Zanuy S, Carrillo M, Larhammar D 2000 Molecular evolution of the neuropeptide Y (NPY) family of peptides: cloning of three NPY-related peptides from the sea bass (Dicentrarchus labrax). Regul Pept 95:25-34
25. Cerdá-Reverter JM, Martinez-Rodriguez G, Anglade I, Kah O, Zanuy S 2000 Peptide YY (PYY) and fish pancreatic peptide Y (PY) expression in the brain of the sea bass (Dicentrarchus labrax) as revealed by in situ hybridization. J Comp Neurol 426:197-208
26. Peter RE, Gill VE 1975 A stereotaxical atlas and technique for forebrain nuclei of the goldfish, Carassius auratus. J Comp Neurol 159:69-101
27. Ohno S, Muramoto J, Christiansen L 1967 Dipoloid-tetraploid relationships among old world members of the fish family Cyprinidae. Chromosoma 23:1-9
28. Bures EJ, Hui JO, Young Y, Chow DT, Katta V, Rohde MF, Zeni L, Rosenfeld RD, Strak KL, Haniu M 1998 Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylation. Biochemistry 37:12172-12177
29. Perry WL, Nakamura T, Swing DA, Secrest L, Eagleson B, Hustad CM, Copeland NG, Jenkins NA 1996 Couple site-directed mutagenesis/transgenesis identifies important functional domains of the mouse agouti protein. Genetics 144:255-264
30. Rosenfeld RD, Zeni L, Welcher AA, Narhi LO, Hale C, Marasco J, Delaney J, Gleason T, Philo JS, Katta V, Hui J, Baumgartner J, Graham M, Stark KL, Karbon W 1998 Biochemical, biophysical and pharmacological characterization of bacterially expressed human agouti-related protein. Biochemistry 37:16046-16052
31. Bolin KA, Anderson DJ, Trulson JA, Thompson DA, Wilken J, Kent SBH, Gantz I, Millhauser GL 1999 NMR structure of a minimized human agouti related protein prepared by total chemical synthesis. FEBS Lett 451:125-131
32. Jackson PJ, McNulty JC, Yang Y-K, Thompson DA, Chai B, Gantz I, Barsh CS, Millhauser GL 2002 Design, pharmacology, and NMR structure of a minimized cysteine knot with agouti-related protein activity. Biochemistry 41:7565-7572
33. Tota MR, Smith TS, Mao C, MacNeil T, Mosley RT, Van der Ploeg LHT, Fong TM 1999 Molecular interaction of agouti protein and agouti-related protein with human receptors. Biochemistry 38:897-904
34. Vrieling H, Duhl DMJ, Millar SE, Miller KA, Barsh GS 1994 Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene. Proc Natl Acad Sci USA 91:5667-5671
35. Boswell T, Li Q, Takeuchi S 2002 Neurons expressing neuropeptide Y mRNA in the infundibular hypothalamus of Japanese quail are activated by fasting and co-express agouti-related protein mRNA. Mol Brain Res 100:31-42
36. Peng C, Gallin W, Peter RE, Blomqvist AG, Larhammar D 1994 Neuropeptide-Y gene expression in the goldfish brain: distribution and regulation by ovarian steroids. Endocrinology 134:1095-1103
37. Vecino E, Perez MT, Ekstrom P 1994 In situ hybridization of neuropeptide Y (NPY) mRNA in the goldfish brain. Neuroreport 6:127-131
38. Narnaware YK, Peter RE 2001 Effects of food deprivation and refeeding on neuropeptide Y (NPY) mRNA levels in goldfish. Comp Biochem Physiol 129B:633-637
39. Narnaware YK, Peyon PP, Lin X, Peter RE 2000 Regulation of food intake by neuropeptide Y in goldfish. Am J Physiol 279:R1025-R1034
40. Pickavance LC, Staines WA, Fryer JN 1992 Distributions and colocalization of neuropeptide Y and somatostatin in the goldfish brain. J Chem Neuroanat 5:221-233
41. Baker BI 1991 Melanin-concentrating hormone: a general vertebrate polypeptide. Int Rev Cytol 126:1-47
42. Mizuno TM, Mobbs CV 1999 Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology 140:814-817
43. Yada T, Moriyama S, Suzuki Y, Azuma T, Takahashi A, Hirose S, Naito N 2002 Relationship between obesity and metabolic hormones in the "cobalt" variant of rainbow trout. Gen Comp Endocrinol 128:36-43