Evaluation of nonthreshold leukemogenic response to methyl nitrosourea in p53-deficient C3H/He mice

Toxicology and Applied Pharmacology

Volumn 190, Issue 3, 2003, Pages 251-261

  Hirabayashi, Yoko ^a   Yoshida, Kazuko ^b   Aizawa, Shin Ichi ^c   Kodama, Yukio ^a   Kanno, Jun ^a   Kurokawa, Yuji ^a   Yoshimura, Isao ^d   Inoue, Tohru ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c RIKEN Center for Biosystems Dynamics Research   (Japan)

^d TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Chemical carcinogenesis; Genotoxic carcinogenesis; p53 deficiency; p53 knockout mice; Threshold and nonthreshold

Indexed keywords

CARCINOGEN; METHYLNITROSOUREA; PROTEIN P53;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; BODY WEIGHT; BONE MARROW CELL; CARCINOGENESIS; CELL POPULATION; DNA DAMAGE; DNA REPAIR; FEMALE; GENOTOXICITY; LEUKEMOGENESIS; LINEAR REGRESSION ANALYSIS; MOUSE; NONHUMAN; PROTEIN DEFICIENCY; STATISTICAL ANALYSIS;

EID: 0043094103     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00185-6     Document Type: Article

References (56)

1. Batschelet E. Introduction to Mathematics for Life Scientists. 1979;Springer-Verlag, Berlin.
2. Berenblum I., Shubik P. A new quantitative approach to the study of stages of chemical carcinogenesis in the mouse's skin. Br. J. Cancer. 1:1947;383.
3. Bougeard G., Brugieres L., Chompret A., Gesta P., Charbonnier F., Valent A., Martin C., Raux G., Feunteun J., Paillerets B.B., Frebourg T. Screening for TP53 rearrangements in families with the Li-Fraumeni syndrome reveals a complete deletion of the TP53 gene. Oncogene. 22:2003;840-846.
4. Bridges B.A., Stamper J.G. Hypothetical dose-response curves for chronic exposures to mutagens or carcinogens subject to simple enzymatic detoxification in the mammalian body. Mutat. Res. 33:1975;87-91.
5. Chomentowski M., Kellerer A.M., Pierce D.A. Radiation dose dependences in the atomic bomb survivor cancer mortality data a model-free visualization . Radiat. Res. 153:2000;289-294.
6. Counts J.L., Goodman J.I. Hypomethylation of DNA a possible epigenetic mechanism involved in tumor promotion . Prog. Clin. Biol. Res. 391:1995;81-101.
7. Dobson A.J. An Introduction to Generalized Linear Models. second ed. 2002;Chapman & Hall/CRC, Washington, DC.
8. Ehling U.H., Averbeck D., Cerutti P.A., Friedman J., Greim H., Kolbye A.C. Jr., Mendelsohn M.L. International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC publication no. 10, Review of the evidence for the presence or absence of thresholds in the induction of genetic effects by genotoxic chemicals. Mutat. Res. 123:1983;281-341.
9. Elhajouji A., Van Hummelen P., Kirsch-Volders M. Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes. Environ. Mol. Mutagen. 26:1995;292-304.
10. Falk H.L. Possible mechanisms of combination effects in chemical carcinogenesis. Oncology. 33:1976;77-85.
11. Frei J.V., Lawley P.D. Thymomas induced by simple alkylating agents in C57BL/Cbi mice kinetics of the dose response . J. Natl. Cancer Inst. 64:1980;845-856.
12. French J.E., Lacks G.D., Trempus C., Dunnick J.K., Foley J., Mahler J., Tice R.R., Tennant R.W. Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen- and tissue-dependent. Carcinogenesis. 22:2001;99-106.
13. Fry R.J. The question of thresholds for carcinogenesis. Cancer Invest. 7:1989;299-300.
14. Gehring P.J., Blau G.E. Mechanisms of carcinogenesis dose response . J. Environ. Pathol. Toxicol. 1:1978;163-179.
15. Goodman J.I., Counts J.L. Hypomethylation of DNA a possible nongenotoxic mechanism underlying the role of cell proliferation in carcinogenesis . Environ. Health Perspect. 101:(Suppl. 5):1993;169-172.
16. Harvey M., McArthur M.J., Montgomery C.A. Jr., Butel J.S., Bradley A., Donehower L.A. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat. Genet. 5:1993;225-229.
17. Henschler D. New approaches to a definition of threshold values for "irreversible" toxic effects? Arch. Toxicol. 32:1974;63-67.
18. Hirabayashi Y., Inoue T., Suda Y., Aizawa S., Ikawa Y., Kanisawa M. Hemopoietic neoplasms in lethally irradiated mice repopulated with bone marrow cells carrying the human c-myc oncogene a repopulation assay . Exp. Hematol. 20:1992;167-172.
19. Hirabayashi Y., Matsuda M., Matumura T., Mitsui H., Sasaki H., Tukada T., Aizawa S., Yoshida K., Inoue T. The p53-deficient hemopoietic stem cells their resistance to radiation apoptosis, but lasted transiently . Leukemia. 11:(Suppl. 3):1997;489-492.
20. Inoue T., Cronkite E.P., Commerford S.L., Carsten A.L. Residual toxicity in hematopoietic cells following a single dose of methylnitrosourea. Leuk. Res. 8:1984;105-116.
21. Kemp C.J. Hepatocarcinogenesis in p53-deficient mice. Mol. Carcinog. 12:1995;132-136.
22. Kemp C.J., Wheldon T., Balmain A. p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat. Genet. 8:1994;66-69.
23. Kirsch-Volders M., Aardema M., Elhajouji A. Concepts of threshold in mutagenesis and carcinogenesis. Mutat. Res. 464:2000;3-11.
24. Le X.C., Xing J.Z., Lee J., Leadon S.A., Weinfeld M. Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage. Science. 280:1998;1066-1069.
25. Li F.P., Fraumeni J.F. Soft-tissue sarcomas, breast cancer, and other neoplasms a familial syndrome? Ann. Intern. Med. 71:1969;747-752.
26. Liao M.J., Zhang X.X., Hill R., Gao J., Qumsiyeh M.B., Nichols W., Van Dyke T. No requirement for V(D)J recombination in p53-deficient thymic lymphoma. Mol. Cell. Biol. 18:1998;3495-3501.
27. Littlefield N.A., Farmer J.H., Gaylor D.W., Sheldon W.G. Effects of dose and time in a long-term, low-dose carcinogenic study. J. Environ. Pathol. Toxicol. 3:1980;17-34.
28. Lovell D.P. Dose-response and threshold-mediated mechanisms in mutagenesis statistical models and study design . Mutat. Res. 464:2000;87-95.
29. Marcus W.L., Rispin A.S. Threshold carcinogenicity using arsenic as an example. Cothern C., Mehlman M., Marcus W.L. Risk Assessment and Risk Management of Industrial and Environmental Chemicals, Vol. 15. 1988;133-159 Princeton Scientific Publishing, Princeton, NJ.
30. Malkin D., Li F.P., Strong L.C., Fraumeni J.F., Nelson C.E., Kim D.H., Kassel J., Gryka M.A., Bischoff F.Z., Tainsky M.A., Friend S.H. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 250:1990;1233-1238.
31. Moragoda L., Jaszewski R., Kulkarni P., Majumdar A.P. Age-associated loss of heterozygosity of tumor suppressor genes in the gastric mucosa of humans. Am J. Physiol. Gastrointest. Liver Physiol. 282:2002;G932-G936.
32. Moustacchi E. DNA damage and repair consequences on dose-responses . Mutat. Res. 464:2000;35-40.
33. Muckerheide J. (Ed.), 2001 Low-level radiation health effects: compiling the data, second edition, revision 4. Radiation, Science, & Health, ( http://cnts.wpi.edu/RSH/Data_Docs/index.html ).
34. O'Connor P.J., Manning F.C., Gordon A.T., Billett M.A., Cooper D.P., Elder R.H., Margison G.P. DNA repair kinetics and thresholds . Toxicol. Pathol. 28:2000;375-381.
35. Oesch F., Herrero M.E., Hengstler J.G., Lohmann M., Arand M. Metabolic detoxification implications for thresholds . Toxicol. Pathol. 28:2000;382-387.
36. Pierce D.A., Preston D.L. Radiation-related cancer risks at low doses among atomic bomb survivors. Radiat. Res. 154:2000;178-186.
37. Povey A.C. DNA adducts endogenous and induced . Toxicol. Pathol. 28:2000;405-414.
38. Purchase I.F. Current knowledge of mechanisms of carcinogenicity genotoxins versus non-genotoxins . Hum. Exp. Toxicol. 13:1994;17-28.
39. Purchase I.F., Auton T.R. Thresholds in chemical carcinogenesis. Regul. Toxicol. Pharmacol. 22:1995;199-205.
40. Rudel R., Slayton T.M., Beck B.D. Implications of arsenic genotoxicity for dose response of carcinogenic effects. Regul. Toxicol. Pharmacol. 23:1996;87-105.
41. Schulte-Hermann R., Grasl-Kraupp B., Bursch W. Dose-response and threshold effects in cytotoxicity and apoptosis. Mutat. Res. 464:2000;13-18.
42. Seo Y.R., Fishel M.L., Amundson S., Kelley M.R., Smith M.L. Implication of p53 in base excision DNA repair in vivo evidence . Oncogene. 21:2002;731-737.
43. Smith M.L., Seo Y.R. p53 regulation of DNA excision repair pathways. Mutagenesis. 17:2002;149-156.
44. Tanaka T., Suda T., Suda J., Inoue T., Hirabayashi Y., Hirai H., Takaku F., Miura Y. Stimulatory effects of granulocyte colony-stimulating factor on colony-forming units-spleen (CFU-S) differentiation and pre-CFU-S proliferation in mice. Blood. 77:1991;2597-2602.
45. Terracini B., Testa M.C., Cabral J.R., Rossi L. The roles of age at treatment and dose in carcinogenesis in C3Hf/Dp mice with a single administration of N-nitroso-N-methylurea. Br. J. Cancer. 33:1976;427-439.
46. Till J.E., McCulloch E.A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res. 14:1961;213-222.
47. Toft N.J., Curtis L.J., Sansom O.J., Leitch A.L., Wyllie A.H., te Riele H., Arends M.J., Clarke A.R. Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2-deficient background. Oncogene. 21:2002;6299-6306.
48. Tsukada T., Tomooka Y., Takai S., Ueda Y., Nishikawa S., Yagi T., Tokunaga T., Takeda N., Suda Y., Abe S., Matsuo I., Ikawa Y., Aizawa S.-I. Enhanced proliferative potential in culture of cells from p53-deficient mice. Oncogene. 8:1993;3313-3322.
49. United Nations Scientific Committee on the Effects of Atomic Radiation 1986. Dose-response relationship for radiation-induced cancer, in: Genetic and Somatic Effects of Ionizing Radiation: United Nations Scientific Committee on the Effects of Atomic Radiation, 1986 Report to the General Assembly, with annexes. United Nations, New York. Annexes B, pp. 1-262.
50. Weisburger J.H., Williams G.M. Types and amounts of carcinogens as potential human cancer hazards. Cell Biol. Toxicol. 5:1989;377-391.
51. Williams G.M., Iatropoulos M.J., Jeffrey A.M. Mechanistic basis for nonlinearities and thresholds in rat liver carcinogenesis by the DNA-reactive carcinogens 2-acetylaminofluorene and diethylnitrosamine. Toxicol. Pathol. 28:2000;388-395.
52. Yamamoto S., Mitsumori K., Kodama Y., Matsunuma N., Manabe S., Okamiya H., Suzuki H., Fukuda T., Sakamaki Y., Sunaga M., Nomura G., Hioki K., Wakana S., Nomura T., Hayashi Y. Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice. Carcinogenesis. 17:1996;2455-2461.
53. Yoshida K., Aizawa S., Watanabe K., Hirabayashi Y., Inoue T. Stem-cell leukemia P53 deficiency mediated suppression of leukemic differentiation in C3H/He myeloid leukemia . Leuk. Res. 26:2002;1085-1092.
54. Yoshida K., Inoue T., Nojima K., Hirabayashi Y., Sado T. Calorie restriction reduces the incidence of myeloid leukemia induced by a single whole-body radiation in C3H/He mice. Proc. Natl. Acad. Sci. USA. 94:1997;2615-2619.
55. Yoshida K., Nemoto K., Nishimura M., Hayata I., Inoue T., Seki M. Nature of leukemic stem cells in murine myelogenous leukemia. Int. J. Cell Cloning. 4:1986;91-102.
56. Zeise L., Wilson R., Crouch E.A. Dose-response relationships for carcinogens a review . Environ. Health Perspect. 73:1987;259-306.