Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage

Science

Volumn 280, Issue 5366, 1998, Pages 1066-1069

  Le, X Chris ^a   Xing, James Z ^a   Lee, Jane ^b   Leadon, Steven A ^c   Weinfeld, Michael ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CROSS CANCER INSTITUTE   (Canada)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIHYDRO 5,6 DIHYDROXYTHYMINE; DNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DNA DAMAGE; DNA DETERMINATION; DNA REPAIR; HUMAN; HUMAN CELL; INCUBATION TIME; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY;

ANTIBODIES, MONOCLONAL; BROMODEOXYURIDINE; DNA DAMAGE; DNA REPAIR; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTROPHORESIS, CAPILLARY; HUMANS; RADIATION, IONIZING; THYMINE; TUMOR CELLS, CULTURED;

EID: 0032524396     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5366.1066     Document Type: Article

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44. We thank N. Dovichi, S. Hrudey, and T. Lindahl for reviewing the manuscript and M. Ma, L. Ye, W. Ansbacher, and S. Kuny for technical assistance. Supported by grants from the Natural Sciences and Engineering Research Council of Canada, the National Cancer Institute of Canada, the Alberta Heritage Foundation for Medical Research through the Eco-Research Chair, the Alberta Cancer Board, and NIH (CA40453 and CA62059).