Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background

Oncogene

Volumn 21, Issue 41, 2002, Pages 6299-6306

  Toft, Neil J ^a,b   Curtis, Lucy J ^a,b   Sansom, Owen J ^a,b   Leitch, Andrea L ^a,b   Wyllie, Andrew H ^d   Te Riele, Hein ^c   Arends, Mark J ^d   Clarke, Alan R ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Apoptosis; Microsatellite instability; Mismatch repair; p53; Tumorigenesis

Indexed keywords

PROTEIN MSH2; PROTEIN P53;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SURVIVAL; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CONTROLLED STUDY; EMBRYO; GENOME; GENOTYPE; HETEROZYGOSITY; KNOCKOUT MOUSE; LYMPHOMA; MICROSATELLITE INSTABILITY; MISMATCH REPAIR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; BASE PAIR MISMATCH; DNA REPAIR; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HETEROZYGOTE; MICE; MICROSATELLITE REPEATS; MUTS HOMOLOG 2 PROTEIN; NEOPLASMS, EXPERIMENTAL; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS;

ANIMALIA;

EID: 0037068740     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1205727     Document Type: Article

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