Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia

Human Molecular Genetics

Volumn 12, Issue 16, 2003, Pages 2063-2076

  Wong, Jasmine C Y ^a,b   Alon, Noa ^a   Mckerlie, Colin ^a,c   Huang, Jun R ^a   Meyn, M Stephen ^a,b   Buchwald, Manuel ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; BRCA1 PROTEIN; FANCONI ANEMIA GROUP A PROTEIN; NEOMYCIN; NUCLEAR PROTEIN; PROTEIN MLH1; RAD51 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; CELL MIGRATION; CELL POPULATION; CHROMOSOME PAIRING; CONTROLLED STUDY; CRANIOFACIAL MALFORMATION; EXON; FANCONI ANEMIA; FEMALE; GENE CASSETTE; GENE CONSTRUCT; GENE DISRUPTION; GENE FUNCTION; GENE MUTATION; GENE TARGETING; GENETIC ANALYSIS; GENETIC RECOMBINATION; GONAD; GROWTH RETARDATION; HOMOZYGOTE; HYPOGONADISM; HYPOPLASIA; IN VIVO STUDY; INCIDENCE; INFERTILITY; MALE; MEIOSIS; MICROPHTHALMIA; NONHUMAN; OVARY CYST; PACHYTENE; PHENOTYPE; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPORTER GENE; REPRODUCTION; REVIEW; SENESCENCE; SPERMATOCYTE;

ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; EXONS; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP A PROTEIN; FEMALE; FETAL GROWTH RETARDATION; GENE TARGETING; GERM CELLS; INFERTILITY, FEMALE; INFERTILITY, MALE; MALE; MEIOSIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROPHTHALMOS; PHENOTYPE; PROTEINS;

ANIMALIA;

EID: 0042921156     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddg219     Document Type: Review

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