In vitro phenotypic correction of hematopoietic progenitors from Fanconi anemia group A knockout mice

Blood

Volumn 100, Issue 6, 2002, Pages 2032-2039

  Río, Paula ^a,b,c   Segovia, José Carlos ^a,b,c   Hanenberg, Helmut ^a,b,c   Casado, José Antonio ^a,b,c   Martínez, Jesús ^a,b,c   Göttsche, Kerstin ^a,b,c   Cheng, Ngan Ching ^a,b,c   Van De Vrugt, Henri J ^a,b,c   Arwert, Fré ^a,b,c   Joenje, Hans ^a,b,c   Bueren, Juan A ^a,b,c  

^a CIEMAT   (Spain)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FANCONI ANEMIA GROUP A PROTEIN; GENE PRODUCT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GREEN FLUORESCENT PROTEIN; MITOMYCIN C; RETROVIRUS VECTOR; STEM CELL FACTOR; UNCLASSIFIED DRUG; VIRUS VECTOR;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL GROWTH; COLONY FORMING UNIT; CONTROLLED STUDY; FANCONI ANEMIA; GENE MUTATION; GENETIC TRANSDUCTION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; KNOCKOUT MOUSE; MEGAKARYOCYTE; MOUSE; NONHUMAN; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL;

EID: 0037105463     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v100.6.2032.h81802002032_2032_2039     Document Type: Article

References (47)

1. Molecular biology of Fanconi anemia: Implications for diagnosis and therapy
2. The emerging genetic and molecular basis of Fanconi anaemia
3. Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA
4. Cloning of cDNAs for Fanconi's anaemia by functional complementation
5. Positional cloning of a novel Fanconi anemia gene, FANCD2
6. Isolation of a cDNA representing the Fanconi anemia complementation group E gene
7. The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM
8. The Fanconi anaemia group G gene FANCG is identical With XRCC9
9. The Fanconi anemia protein. FANCF forms a nuclear complex with FANCA, FANCC and FANCG
10. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway
11. Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia
12. Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene
13. Mice with a targeted disruption of the Fanconi anemia homolog Fanca
14. Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice
15. Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9
16. Hematopoietic compartment of Fanconi anemia group C null mice contains fewer lineage-negative CD34+ primitive hematopoietic cells and shows reduced reconstruction ability
17. Loss of FancC function results in decreased hematopoietic stem cell repopulating ability
18. Disease model: Fanconi anemia
19. Severe leukopenia and dysregulated erythropoiesis in SCID mice persistently infected with the parvovirus minute virus of mice
20. In vitro and in vivo susceptibility of mouse megakaryocytic progenitors to strain of parvovirus minute virus of mice
21. A flow cytometry assay simultaneously detects independent apoptotic parameters
22. Versatile retroviral vectors for potential use in gene therapy
23. Phenotipic correction of primary Fanconi anemia T cells with retroviral vectors as a diagnostic tool
24. Efficient transduction of human hematopoietic repopulating cells generating stable engraftment of transgene-expressing cells in NOD/SCID mice
25. Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells
26. Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells
27. Preserved long-term repopulation and differentiation properties of hematopoietic grafts subjected to ex vivo expansion with stem cell factor and interleukin 11
28. Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase
29. Assessment of mitomycin C sensitivity in Fanconi anemia complementation group C gene (Fac) knock-out mouse cells
30. Bone marrow failure in the Fanconi anemia group C mouse model after DNA damage
31. Multiple inhibitory cytokines induce deregulated progenitor growth and apoptosis in hematopoietic cells from Fac-/- mice
32. Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of Fanconi anemia complementation group C cells to interferon gamma, tumor necrosis factor-alpha, and double-stranded RNA
33. The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors
34. Increased expression of Fas antigen on bone marrow CD34+ cells of patients with aplastic anaemia
35. Suppression of apoptosis in hematopoietic factor-dependent progenitor cell lines by expression of the FAC gene
36. Inactivation of the Fanconi anemia group C gene augments interferon-gamma-induced apoptotic responses in hematopoietic cells
37. Tumor necrosis factor-alpha and CD95 ligation suppress erythropoiesis in Fanconi anemia C gene knockout mice
38. The Fanconi anemia group C gene product: Signaling functions in hematopoietic cells
39. Interferon-gamma-induced apoptotic responses of Fanconi anemia group C hematopoietic progenitor cells involve caspase 8-dependent activation of caspase 3 family members
40. FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity
41. Functional correction of FA-C cells with FANCC suppresses the expression of interferon gamma-inducible genes
42. Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1
43. In vitro production of CFU-S and cells with erythropoiesis repopulating ability by 5-fluorouracil treated mouse bone marrow
44. Studies of hematopoietic stem cells spared by 5-fluorouracil
45. Spontaneous functional correction of homozygous Fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism
46. Somatic mosaicism in Fanconi anemia: Evidence of genotypic reversion in lymphohematopoietic stem cells