Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modifications

Genes and Development

Volumn 16, Issue 14, 2002, Pages 1766-1778

  Nakagawa, Hiromi ^a   Lee, Joon Kyu ^b   Hurwitz, Jerard ^b   Allshire, Robin C ^c   Nakayama, Jun Ichi ^a,d   Grewal, Shiv I S ^d   Tanaka, Katsunori ^e   Murakami, Yota ^a  

^a KYOTO UNIVERSITY   (Japan)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

^d Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^e SHIMANE UNIVERSITY   (Japan)

Author keywords

CENP B; Centromere; Fission yeast; Heterochromatin; Histone modification

Indexed keywords

CENTROMERE PROTEIN B; HISTONE; PROTEIN; PROTEIN ABP1; PROTEIN CBH1; PROTEIN CBH2; UNCLASSIFIED DRUG;

ARTICLE; CENTROMERE; CONTROLLED STUDY; DEACETYLATION; DROSOPHILA; EUKARYOTIC CELL; GENE DISRUPTION; GENE SILENCING; GENOTYPE; HETEROCHROMATIN; IMMUNOPRECIPITATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN METHYLATION; PROTEIN MODIFICATION; SCHIZOSACCHAROMYCES POMBE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AUTOANTIGENS; BINDING SITES; CENTROMERE; CENTROMERE PROTEIN B; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE SILENCING; HETEROCHROMATIN; HISTONES; MICROFILAMENT PROTEINS; MUTAGENESIS; MUTAGENESIS, INSERTIONAL; PHENOTYPE; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TRANSCRIPTION FACTORS;

EUKARYOTA; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE;

EID: 0037099483     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.997702     Document Type: Article

References (65)

1. Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31
2. Position effect variegation at fission yeast centromeres
3. Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation
4. CENP-A, -B, and -C chromatin complex that contains the I-type α-satellite array constitutes the prekinetochore in HeLa cells
5. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
6. Fission yeast homologs of human CENP-B have redundant functions affecting cell growth and chromosome segregation
7. The centromeric K-type repeat and the central core are together sufficient to establish a functional Schizosaccharomyces pombe centromerc
8. Requirement of heterochromatin for cohesion at centromeres
9. Retinoblastoma protein meets chromatin
10. Analysis of centromeric DNA in the fission yeast Schizosaccharomyces pombe
11. CENP-B: A major human centromere protein located beneath the kinetochore
12. The HP1 protein family: Getting a grip on chromatin
13. The chromodomain protein Swi6: A key component at fission yeast centromeres
14. Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres
15. Fission yeast mutants that alleviate transcriptional silencing in centromeric flanking repeats and disrupt chromosome segregation
16. Structural organization and functional analysis of centromeric DNA in the fission yeast Schizosaccharomyces pombe
17. Transcriptional silencing in fission yeast
18. The use of cell division cycle mutants to investigate the control of microtubule distribution in the fission yeast Schizosaccharomyces pombe
19. Identification of DNA regions required for mitotic and meiotic functions within the centromere of Schizosaccharomyces pombe chromosome I
20. A centromere DNA-binding protein from fission yeast affects chromosome segregation and has homology to human CENP-B
21. Formation of de novo centromeres and construction of first-generation human artificial microchromosomes
22. Heterochromatin function in complex genomes
23. Centromere protein B null mice are mitotically and meiotically normal but have lower body and testis weights
24. Construction of YAC-based mammalian artificial chromosomes
25. Functional redundancies, distinct localizations and interactions among three fission yeast homologs of centromere protein-B
26. Translating the histone code
27. The cenpB gene is not essential in mice
28. The case for epigenetic effects on centromere identity and function
29. Reversion of autonomously replicating sequence mutations in Saccharomyces cerevisiae: Creation of a eucaryotic replication origin within procaryotic vector DNA
30. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
31. Purification and characterization of a CENP-B homologue protein that binds to the centromeric K-type repeat DNA of Schizosaccharomyces pombe
32. Correlation between histone lysine methylation and developmental changes at the chicken β-globin locus
33. Silencing and heritable domains of gene expression
34. Mechanism of silencing in Saccharomyces cerevisiae
35. Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component
36. A human centromere antigen (CENP-B) interacts with a short specific sequence in alphoid DNA, a human centromeric satellite
37. Construction and characterization of centric circular and acentric linear chromosomes in fission yeast
38. Common themes in mechanisms of gene silencing
39. Regulation of p34cdc2 protein kinase during mitosis
40. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
41. Identification, purification, and molecular cloning of autonomously replicating sequence-binding protein 1 from fission yeast Schizosaccharomyces pombe
42. Centromere protein B assembles human centromeric α-satellite DNA at the 17-bp sequence, CENP-B box
43. Chromosome walking shows a highly repetitive sequence present in all the centromere regions of Schizosaccharomyces pombe chromosomes
44. A novel sequence common to the centromere regions of Schizosaccharomyces pombe
45. A chromodomain protein, Swi6, performs imprinting functions in fission yeast during mitosis and meiosis
46. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly
47. Rb targets histone H3 methylation and HP1 to promoters
48. Telomereassociated chromosome breakage in fission yeast results in variegated expression of adjacent genes
49. Construction of a minichromosome by deletion and its mitotic and meiotic behaviour in fission yeast
50. Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries
51. Recruitment of cohesin to heterochromatic regions by Swi6/HPI in fission yeast
52. Distinct protein interaction domains and protein spreading in a complex centromere
53. Centromeric protein B null mice are viable with no apparent abnormalities
54. Regulation of chromatin structure by sitespecific histone H3 methyltransferases
55. A low copy number central sequence with strict symmetry and unusual chromatin structure in fission yeast centromere
56. Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast
57. Crystal structure of the CENP-B protein-DNA complex: The DNA-binding domains of CENP-B induce kinks in the CENP-B box DNA
58. The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes
59. Histone acetylation in chromatin and chromosomes
60. Beyond the nucleosome: Epigenetic aspects of position-effect variegation in Drosophila
61. Nucleotide sequence heterogeneity of α satellite repetitive DNA: A survey of alphoid sequences from different chromosomes
62. Definition of individual components within the cytoskeleton of Trypanosoma brucei by a library of monoclonal antibodies
63. 2 terminus, which is separable from dimerizing activity
64. In vitro assembly of the CENP-B/α-satellite DNA/core histone complex: CENP-B causes nucleosome positioning