Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase

Acta Crystallographica - Section D Biological Crystallography

Volumn 59, Issue 4, 2003, Pages 654-661

  Cody, Vivian ^a   Galitsky, Nikolai ^a   Luft, Joseph R ^a   Pangborn, Walter ^a   Gangjee, Aleem ^b  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

^b DUQUESNE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; DRUG DERIVATIVE; FOLIC ACID; FOLIC ACID ANTAGONIST; POLYMER; TRIMETREXATE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; FOLIC ACID; FOLIC ACID ANTAGONISTS; HUMANS; MODELS, MOLECULAR; POLYMERS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETREXATE;

EID: 0037391198     PISSN: 09074449     EISSN: None     Source Type: Journal    
DOI: 10.1107/S0907444903001951     Document Type: Article

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