The single sulfur to oxygen substitution in the active site nucleophile of the Yersinia protein-tyrosine phosphatase leads to substantial structural and functional perturbations

Biochemistry

Volumn 36, Issue 6, 1997, Pages 1362-1369

  Zhang, Zhong Yin ^a   Wu, Li ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLAMIDE; BACTERIAL ENZYME; GUANIDINE; IODIDE; MUTANT PROTEIN; PROTEIN TYROSINE PHOSPHATASE; SULFUR; UREA;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PURIFICATION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; YERSINIA;

BINDING SITES; CIRCULAR DICHROISM; CYSTEINE; MUTAGENESIS, SITE-DIRECTED; OXYGEN; POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION; PROTEIN-TYROSINE-PHOSPHATASE; SERINE; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR; YERSINIA ENTEROCOLITICA;

EID: 0031024565     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9624043     Document Type: Article

References (36)

1. Barford, D., Flint, A. J., & Tonks, N. K. (1994) Science 263, 1397-1404.
2. Bliska, J. B., Clemens, J. C., Dixon, J. E., & Falkow, S. (1992) J. Exp. Med. 176, 1625-1630.
3. Cantor, C. R., & Schimmel, P. R. (1980) Biophysical Chemistry, p 377, W. H. Freeman and Company, San Francisco.
4. Cho, H., Krishnaraj, R., Kitas, E., Bannwarth, W., Walsh, C. T., & Anderson, K. S. (1992) J. Am. Chem. Soc. 114, 7296-7298.
5. Cleland, W. W., & Hengge, A. C. (1995) FASEB J. 9, 1585-1594.
6. Eftink, M. R., & Ghiron, C. A. (1981) Anal. Biochem. 114, 199-227.
7. Fauman, E. B., Yuvaniyama, C., Schubert, H. L., Stuckey, J. A., & Saper, M. A. (1996) J. Biol. Chem. 271, 18780-18788.
8. Garton, A. J., Flint, A. J., & Tonks, N. K. (1996) Mol. Cell. Biol. 16, 6408-6418.
9. Guan, K. L., & Dixon, J. E. (1990) Science 249, 553-556.
10. Guan, K. L., & Dixon, J. E. (1991) J. Biol. Chem. 266, 17026-17030.
11. Hengge, A. C., Sowa, G., Wu, L., & Zhang, Z.-Y. (1995) Biochemistry 34, 13982-13987.
12. Jia, Z., Barford, D., Flint, A. J., & Tonks, N. K. (1995) Science 268, 1754-1758.
13. Kirby, A. J., & Varvoglis, A. G. (1967) J. Am. Chem. Soc. 89, 415-423.
14. Kuntz, I. D., Meng, E. C., & Shoichet, B. K. (1994) Acc. Chem. Res. 27, 117-123.
15. Lakowicz, J. R. (1983) Principles of Fluorescence Spectroscopy, pp 342-381, Plenum Press, New York.
16. Lowry, O. H., Rosebrough, N., Farr, A., & Randall, R. (1951) J. Biol. Chem. 193, 265-275.
17. McClure, G. D., Jr., & Cook, P. F. (1994) Biochemistry 33, 1674-1683.
18. Metzler, D. M. (1971) Biochemistry: Chemical Reactions of the Living Cell, p 728, Academic Press, New York.
19. Milarski, K. L., Zhu, G., Pearl, C. G., McNamara, D. J., Dobrusin, E. M., Maclean, D., Thieme-Sefler, A., Zhang, Z.-Y., Sawyer, T., Decker, S. J., Dixon, J. E., & Saltiel, A. R. (1993) J. Biol. Chem. 268, 23634-23639.
20. Pace, C. N. (1986) Methods Enzymol. 131, 266-280.
21. Schubert, H. L., Fauman, E. B., Stuckey, J. A., Dixon, J. E., & Saper, M. A. (1995) Protein Sci. 4, 1904-1913.
22. Streitwieser, A., Jr., & Heathcock, C. H. (1985) in Introduction to Organic Chemistry, 3rd ed., pp 9 and 757, Macmillan Publishing Company, New York.
23. Streuli, M., Krueger, N. X., Thai, T., Tang, M., & Saito, H. (1990) EMBO J. 9, 2399-2407
24. Stuckey, J. A., Fauman, E. B., Schubert, H. L., Zhang, Z.-Y., Dixon, J. E., & Saper, M. A. (1994) Nature 370, 571-575.
25. Sun, H., Charles, C. H., Lau, L. F., & Tonks, N. K. (1993) Cell 75, 487-493.
26. Ward, L. D. (1985) Methods Enzymol. 117, 400-415.
27. Wo, Y.-Y. P., Zhou, M.-M., Stevis, P., Davis, J. P., Zhang, Z.-Y., & Van Etten, R. L. (1992) Biochemistry 31, 1712-1721.
28. Wu, L., & Zhang, Z.-Y. (1996) Biochemistry 35, 5426-5234.
29. Zhang, Z.-Y. (1990) Mechanistic and Kinetic Studies of the Bovine Heart Low Molecular Weight Phosphotyrosyl Protein Phosphatase, Ph.D. Thesis, Purdue University, West Lafayette, IN.
30. Zhang, Z.-Y., & Dixon, J. E. (1993) Biochemistry 32, 9340-9345.
31. Zhang, Z.-Y., Clemens, J. C., Schubert, H. L., Stuckey, J. A., Fischer, M. W. F., Hume, D. M., Saper, M. A., & Dixon, J. E. (1992) J. Biol. Chem. 267, 23759-23766.
32. Zhang, Z.-Y., Thieme-Sefler, A. M., Maclean, D., Roeske, R., & Dixon, J. E. (1993) Anal. Biochem. 211, 7-15.
33. Zhang, Z.-Y., Wang, Y., & Dixon, J. E. (1994a) Proc. Natl. Acad. Sci. U.S.A. 91, 1624-1627.
34. Zhang, Z.-Y., Wang, Y., Wu, L., Fauman, E., Stuckey, J. A., Schubert, H. L., Saper, M. A., & Dixon, J. E. (1994b) Biochemistry 33, 15266-15270.
35. Zhang, Z.-Y., Palfey, B. A., Wu, L., & Zhao, Y. (1995) Biochemistry 34, 16389-16396.
36. Zhao, Y., & Zhang, Z.-Y. (1996) Biochemistry 35, 11791-11804.