Irreversible inhibition of the HIV-1 protease: Targeting alkylating agents to the catalytic aspartate groups

Journal of the American Chemical Society

Volumn 118, Issue 25, 1996, Pages 5846-5856

  Yu, Z ^a   Caldera, P ^a   McPhee, F ^a   De Voss, J J ^a   Jones, P R ^a   Burlingame, A L ^a   Kuntz, I D ^a   Craik, C S ^a   Ortiz De Montellano, P R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; EPOXIDE; HALOPERIDOL DERIVATIVE; PIPERIDINE DERIVATIVE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; DRUG TARGETING; ENZYME BINDING; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MASS SPECTROMETRY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 0030018856     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja954069w     Document Type: Article

References (0)