SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients

Journal of Biological Chemistry

Volumn 278, Issue 32, 2003, Pages 29593-29599

  Sanzone, Silvia ^a,b   Zeyda, Maximilian ^c   Saemann, Marcus D ^d   Soncini, Maddalena ^a   Holter, Wolfgang ^e   Fritsch, Gerhard ^e   Knapp, Walter ^d   Candotti, Fabio ^f   Stulnig, Thomas M ^c,g   Parolini, Ornella ^a,d  

^a Poliambulanza Hospital   (Italy)

^b Lab Interdisc di Tecnol Avanzate   (Italy)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

^e CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

^g ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; CALCIUM; CHEMICAL ACTIVATION; DISEASES; GENES; IMMUNOLOGY; PROTEINS;

SIGNAL TRANSDUCTION;

BIOCHEMISTRY;

CD150 ANTIGEN; CD3 ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C; PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL AGGREGATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOPATHOGENESIS; LYMPHOPROLIFERATIVE DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; X LINKED LYMPHOPROLIFERATIVE DISEASE;

ANTIGENS, CD3; CALCIUM; CARRIER PROTEINS; CELL ADHESION; CELL DIVISION; CELL LINE, TRANSFORMED; CHROMOSOMES, HUMAN, X; CYTOPLASM; FLOW CYTOMETRY; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-2; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; IONOMYCIN; LYMPHOPROLIFERATIVE DISORDERS; MAP KINASE SIGNALING SYSTEM; MUTAGENS; MUTATION; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN-2; RETROVIRIDAE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS;

HUMAN HERPESVIRUS 4;

EID: 0042531873     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300565200     Document Type: Article

References (52)

1. Morra, M., Howie, D., Grande, M. S., Sayos, J., Wang, N., Wu, C., Engel, P., and Terhorst, C. (2001) Annu. Rev. Immunol. 19, 657-682
2. Nichols, K. E., Harkin, D. P., Levitz, S., Krainer, M., Kolquist, K. A., Genovese, C., Bernard, A., Ferguson, M., Zuo, L., Snyder, E., Buckler, A. J., Wise, C., Ashley, J., Lovett, M., Valentine, M. B., Look, A. T., Gerald, W., Housman, D. E., and Haber, D. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13765-13770
3. Shlapatska, L. M., Mikhalap, S. V., Berdova, A. G., Zelensky, O. M., Yun, T. J., Nichols, K. E., Clark, E. A., and Sidorenko, S. P. (2001) J. Immunol. 166, 5480-5487
4. Nagy, N., Cerboni, C., Mattsson, K., Maeda, A., Gogolak, P., Sumegi, J., Lanyi, A., Szekely, L., Carbone, E., Klein, G., and Klein, E. (2000). Int. J. Cancer 88, 439-447
5. Parolini, O., Weinhausel, A., Kagerbauer, B., Sassmann, J., Holter, W., Gadner, H., Haas, O. A., and Knapp, W. (2003) Immunogenetics 55, 116-121
6. Parolini, S., Bottino, C., Falco, M., Augugliaro, R., Giliani, S., Franceschini, R., Ochs, H. D., Wolf, H., Bonnefoy, J. Y., Biassoni, R., Moretta, L., Notarangelo, L. D., and Moretta, A. (2000) J. Exp. Med. 192, 337-346
7. Czar, M. J., Kersh, E. N., Mijares, L. A., Lanier, G., Lewis, J., Yap, G., Chen, A., Sher, A., Duckett, C. S., Ahmed, R., and Schwartzberg, P. L. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 7449-7454
8. Wu, C., Nguyen, K. B., Pien, G. C., Wang, N., Gullo, C., Howie, D., Sosa, M. R., Edwards, M. J., Borrow, P., Satoskar, A. R., Sharpe, A. H., Biron, C. A., and Terhorst, C. (2001) Nat. Immunol. 2, 410-414
9. Tangye, S. G., Cherwinski, H., Lanier, L. L., and Phillips, J. H. (2000) Mol. Immunol. 37, 493-501
10. Aoukaty, A., and Tan, R. (2002) J. Biol. Chem. 277, 13331-13337
11. Clapham, D. E. (1995) Cell 80, 259-268
12. Berridge, M. J., Lipp, P., and Bootman, M. D. (2000) Nat. Rev. Mol. Cell. Biol. 1, 11-21
13. Zhang, W. G., Sloan-Lancaster, J., Kitchen, J., Trible, R. P., and Samelson, L. E. (1998) Cell 92, 83-92
14. Zhang, W. G., Irvin, B. J., Trible, R. P., Abraham, R. T., and Samelson, L. E. (1999) Int. Immunol. 11, 943-950
15. Fischer, K. D., Tedford, K., and Penninger, J. M. (1998) Semin. Immunol. 10, 317-327
16. Valitutti, S., Dessing, M., Aktories, K., Gallati, H., and Lanzavecchia, A. (1995) J. Exp. Med. 181, 577-584
17. Krawczyk, C., and Penninger, J. M. (2001) J. Leukocyte Biol. 69, 317-330
18. van Kooyk, Y., van Vliet, S. J., and Figdor, C. G. (1999) J. Biol. Chem. 274, 26869-26877
19. Griffiths, E. K., and Penninger, J. M. (2002) Curr. Opin. Immunol. 14, 317-322
20. Krawczyk, C., Oliveira-dos-Santos, A., Sasaki, T., Griffiths, E., Ohashi, P. S., Snapper, S., Alt, F., and Penninger, J. M. (2002) Immunity 16, 331-343
21. Schwartz, R. H. (1992) Cell 71, 1065-1068
22. Karin, M., and Hunter, T. (1995) Curr. Biol. 5, 747-757
23. Garrington, T. P., and Johnson, G. L. (1999) Curr. Opin. Cell Biol. 11, 211-218
24. Bottino, C., Falco, M., Parolini, S., Marcenaro, E., Augugliaro, R., Sivori, S., Landi, E., Biassoni, R., Notarangelo, L. D., Moretta, L., and Moretta, A. (2001) J. Exp. Med. 194, 235-246
25. Latour, S., Gish, G., Helgason, C. D., Humphries, R. K., Pawson, T., and Veillette, A. (2001) Nat. Immunol. 2, 681-690
26. Sayos, J., Martin, M., Chen, A., Simarro, M., Howie, D., Morra, M., Engel, P., and Terhorst, C. (2001) Blood 97, 3867-3874
27. Howie, D., Simarro, M., Sayos, J., Guirado, M., Sancho, J., and Terhorst, C. (2002) Blood 99, 957-965
28. Nakamura, H., Zarycki, J., Sullivan, J. L., and Jung, J. U. (2001) J. Immunol. 167, 2657-2665
29. Parolini, O., Kagerbauer, B., Simonitsch-Klupp, I., Ambros, P., Jaeger, U., Mann, G., Haas, O. A., Morra, M., Gadner, H., Terhorst, C., Knapp, W., and Holter, W. (2002) Ann. Hematol. 81, 441-447
30. Cocks, B. G., Chang, C. C., Carballido, J. M., Yssel, H., de Vries, J. E., and Aversa, G. (1995) Nature 376, 260-263
31. Lewis, J., Eiben, L. J., Nelson, D. L., Cohen, J. I., Nichols, K. E., Ochs, H. D., Notarangelo, L. D., and Duckett, C. S. (2001) Clin. Immunol. (Orlando) 100, 15-23
32. Markowitz, D., Goff, S., and Bank, A. (1988) Virology 167, 400-406
33. Miller, A. D., Garcia, J. V., von Suhr, N., Lynch, C. M., Wilson, C., and Eiden, M. V. (1991) J. Virol. 65, 2220-2224
34. Zeyda, M., Staffler, G., Horejsi, V., Waldhausl, W., and Stulnig, T. M. (2002) J. Biol. Chem. 277, 28418-28423
35. Stulnig, T. M., Berger, M., Sigmund, T., Stockinger, H., Horejsi, V., and Waldhausl, W. (1997) J. Biol. Chem. 272, 19242-19247
36. Taniguchi, T., and Minami, Y. (1993) Cell 73, 5-8
37. Buday, L. (1999) Biochim. Biophys. Acta 1422, 187-204
38. Veillette, A. (2002) Science's STKE http://stke.sciencemag.org/cgi/content/full/OC_sigtrans;2002/120/pe8
39. Sayos, J., Wu, C., Morra, M., Wang, N., Zhang, X., Allen, D., van Schaik, S., Notarangelo, L., Geha, R., Roncarolo, M. G., Oettgen, H., De Vries, J. E., Aversa, G., and Terhorst, C. (1998) Nature 395, 462-469
40. Chan, B., Lanyi, A., Song, H. K., Griesbach, J., Simarro-Grande, M., Poy, F., Howie, D., Sumegi, J., Terhorst, C., and Eck, M. J. (2003) Nat. Cell Biol. 5, 155-160
41. Henning, G., Kraft, M. S., Derfuss, T., Pirzer, R., de Saint-Basile, G., Aversa, G., Fleckenstein, B., and Meinl, E. (2001) Eur. J. Immunol. 31, 2741-2750
42. Latour, S., Roncagalli, R., Chen, R., Bakinowski, M., Shi, X., Schwartzberg, P. L., Davidson, D., and Veillette, A. (2003) Nat. Cell Biol.
43. Finco, T. S., Kadlecek, T., Zhang, W., Samelson, L. E., and Weiss, A. (1998) Immunity 9, 617-626
44. Bubeck Wardenburg, J., Pappu, R., Bu, J. Y., Mayer, B., Chernoff, J., Straus, D., and Chan, A. C. (1998) Immunity 9, 607-616
45. Villalba, M., Bi, K., Rodriguez, F., Tanaka, Y., Schoenberger, S., and Altman, A. (2001) J. Cell Biol. 155, 331-338
46. Villalba, M., Coudronniere, N., Deckert, M., Teixeiro, E., Mas, P., and Altman, A. (2000) Immunity 12, 151-160
47. Moller, A., Dienz, O., Hehner, S. P., Droge, W., and Schmitz, M. L. (2001) J. Biol. Chem. 276, 20022-20028
48. Marinari, B., Costanzo, A., Viola, A., Michel, F., Mangino, G., Acuto, O., Levrero, M., Piccolella, E., and Tuosto, L. (2002) Eur. J. Immunol. 32, 447-456
49. Aguado, E., Richelme, S., Nunez-Cruz, S., Miazek, A., Mura, A. M., Richelme, M., Guo, X. J., Sainty, D., He, H. T., Malissen, B., and Malissen, M. (2002) Science 296, 2036-2040
50. Perez-Villar, J. J., Whitney, G. S., Sitnick, M. T., Dunn, R. J., Venkatesan, S., O'Day, K., Schieven, G. L., Lin, T. A., and Kanner, S. B. (2002) Biochemistry 41, 10732-10740
51. Sommers, C. L., Park, C. S., Lee, J., Feng, C., Fuller, C. L., Grinberg, A., Hildebrand, J. A., Lacana, E., Menon, R. K., Shores, E. W., Samelson, L. E., and Love, P. E. (2002) Science 296, 2040-2043
52. van Kooyk, Y., and Figdor, C. G. (2000) Curr. Opin. Cell Biol. 12, 542-547