Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP

Blood

Volumn 97, Issue 12, 2001, Pages 3867-3874

  Sayós, Joan ^a,b   Martín, Margarita ^a,b   Chen, Alice ^a,b   Simarro, María ^a,b   Howie, Duncan ^a,b   Morra, Massimo ^a,b   Engel, Pablo ^a,b   Terhorst, Cox ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CELL SURFACE RECEPTOR; GLYCOPROTEIN;

ARTICLE; B CELL LYMPHOMA; DYSGAMMAGLOBULINEMIA; EPSTEIN BARR VIRUS; GENE MUTATION; GENETIC TRANSFECTION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; INFECTIOUS MONONUCLEOSIS; LYMPHOID CELL; LYMPHOPROLIFERATIVE DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; VIRUS INFECTION;

EID: 0035878004     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.12.3867     Document Type: Article

References (25)

1. Purtilo D-T, Cassel C-K, Yang J-P, Harper R. X-linked recessive progressive combined variable immunodeficiency. Lancet. 1975;1:935-940.
2. Sayos J, Wu C, Morra M. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 1998;395:462-469.
3. Coffey A-J, Brooksbank R-A, Brandau O. Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene. Nat Genet. 1998;20:129-135.
4. Nichols K-E, Harkin D-P, Levitz S. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci U S A. 1998;95:13765-13770.
5. Tangye S-G, Lazetic S, Woollatt E, Sutherland G-R, Lanier L-L, Phillips J-H. Human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. J Immunol. 1999;162:6981-6985.
6. Tangye S-G, Phillips J-H, Lanier L-L, Nichols K-E. Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome. J Immunol. 2000;165:2932-2936.
7. Parolini S, Bottino C, Falco M, et al. X-linked lymphoproliferative disease: 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells. J Exp Med. 2000;192:337-346.
8. Sayos J, Nguyen K, Wu C, et al. Potential pathways for regulation of NK and T cell responses: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4. Int Immunol. 2000;12:1749-1757.
9. Benoit L, Wang X, Tan R. Defective natural killer cell activation in X-linked lymphoproliferative disease. J Immunol. 2000;7:3549-3553.
10. Poy F, Yaffe M-B, Sayos J, et al. Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Mol Cell. 1999;4:555-561.
11. Cocks B-G, Chang C-C, Carballido J-M, Yssel H, de Vries J-E, Aversa G. A novel receptor involved in T-cell activation. Nature. 1995;376:260-263.
12. Aversa G, Chang C-C, Carballido J-M, Cocks B-G, de Vries J-E. Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, cyclosporin A-sensitive T cell proliferation and IFN-gamma production. J Immunol. 1997;158:4036-4044.
13. Aversa G, Carballido J, Punnonen J, et al. SLAM and its role in T cell activation and Th responses. Immunol Cell Biol. 1997;75:202-205.
14. Carballido J-M, Aversa G, Kaltoft K, et al. Reversal of human allergic T helper 2 responses by engagement of signaling lymphocytic activation molecule. J Immunol. 1997;159:4316-4321.
15. Punnonen J, Cocks B, Carballido J, et al. Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes. J Exp Med. 1997;185:993-1004.
16. Mavaddat N, Mason D-W, Atkinson P-D, et al. Signaling lymphocytic activation molecule (SLAM, CD150) is homophilic but self-associates with very low affinity. J Biol Chem. 2000.
17. Mathew P-A, Garni-Wagner B-A, Land K, et al. Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J Immunol. 1993;151:5328-5337.
18. Garni-Wagner B-A, Purohit A, Mathew P-A, Bennett M, Kumar V. A novel function-associated molecule related to non-MHC-restricted cytotoxicity mediated by activated natural killer cells and T cells. J Immunol. 1993;151:60-70.
19. Brown M-H, Boles K, Anton van der Merwe P, Kumar V, Mathew P-A, Barclay A-N. 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. J Exp Med. 1998;188:2083-2090.
20. Peritt D, Sesok-Pizzini D-A, Schretzenmair R. C1.7 antigen expression on CD8+ T cells in HIV-1-infected patients with progressing disease. J Immunol. 1997;162:7563-7568.
21. Nakajima H, Colonna M. 2B4: an NK cell activating receptor with unique specificity and signal transduction mechanism. Hum Immunol. 2000;61:39-43.
22. Staunton D-E, Fisher R-C, Le Beau M-M. Blast-1 possesses a glycosyl-phosphatidylinositol (GPI) membrane anchor, is related to LFA3 and OX-45, maps to chromosome 1q21-23. J Exp Med. 2000;169:1087-1099.
23. de la Fuente M-A, Pizcueta P, Nadal M, Bosch J, Engel P. CD84 leukocyte antigen is a new member of the Ig superfamily. Blood. 1997;90:2398-2405.
24. Howie D, Sayos J, Terhorst C, Morra M. The gene defective in X-linked lymphoproliferative disease controls T cell dependent immune surveillance against Epstein-Barr virus. Curr Opin Immunol. 2000;12:474-478.
25. Tangye SG, Phillips JH, Lanier LL. The CD2-subset of the Ig superfamily of cell surface molecules: receptor-ligand pairs expressed by NK cells and other immune cells. Semin Immunol 2000;12:149-157.