Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 5, 2001, Pages 641-645

  Fevig, John M ^a   Pinto, Donald J ^a   Han, Qi ^a   Quan, Mimi L ^a   Pruitt, James R ^a   Jacobson, Irina C ^a   Galemmo, Jr, Robert A ^a   Wang, Shuaige ^a   Orwat, Michael J ^a   Bostrom, Lori L ^a   Knabb, Robert M ^a   Wong, Pancras C ^a   Lam, Patrick Y S ^a   Wexler, Ruth R ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BENZAMIDINE DERIVATIVE; BLOOD CLOTTING FACTOR 10A; HETEROCYCLIC COMPOUND; PYRAZOLE DERIVATIVE; TETRAZOLE DERIVATIVE; THIAZOLE DERIVATIVE; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; NONHUMAN; RABBIT;

ANIMALS; BENZAMIDINES; FACTOR XA; HETEROCYCLIC COMPOUNDS; HUMANS; KINETICS; MOLECULAR STRUCTURE; RABBITS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035848415     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00029-4     Document Type: Article

References (16)