Design, synthesis and biological activity of novel non-amidine factor Xa inhibitors. Part 1: P1 structure-activity relationships of the substituted 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 12, 2002, Pages 1651-1655

  Jia, Zhaozhong J ^a   Wu, Yanhong ^a   Huang, Wenrong ^a   Goldman, Erick ^a   Zhang, Penglie ^a   Woolfrey, John ^a   Wong, Paul ^a   Huang, Brian ^a   Sinha, Uma ^a   Park, Gary ^a   Reed, Andrea ^a   Scarborough, Robert M ^a   Zhu, Bing Yan ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; AMIDINE; BENZAMIDINE DERIVATIVE; BLOOD CLOTTING FACTOR 10A INHIBITOR; NAPHTHYL GROUP; PYRAZOLE DERIVATIVE; SN 429; UNCLASSIFIED DRUG; BLOOD CLOTTING FACTOR 10A; SERINE PROTEINASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME SPECIFICITY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; SYNTHESIS;

AMIDES; ANIMAL; DRUG DESIGN; FACTOR XA; PYRAZOLES; RATS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; ANIMALS;

EID: 0037124198     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00239-1     Document Type: Article

References (13)