Isoxazolines and Isoxazoles as Factor Xa inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 8, 2000, Pages 685-689

  Pruitt, James R ^a   Pinto, Donald J ^a   Estrella, Melissa J ^a   Bostrom, Lori L ^a   Knabb, Robert M ^a   Wong, Pancras C ^a   Wright, Matthew R ^a   Wexler, Ruth R ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLIC ACID; BENZALDEHYDE DERIVATIVE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; DIAZOMETHANE; ESTER; ISOXAZOLE DERIVATIVE; ISOXAZOLINE DERIVATIVE; OXIME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOVENOUS SHUNT; ARTICLE; CHEMICAL MODIFICATION; COMPARATIVE STUDY; DOG; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; FEMORAL ARTERY; FEMORAL VEIN; NONHUMAN; RABBIT; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOSIS;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; FACTOR XA; ISOXAZOLES; MODELS, MOLECULAR; RABBITS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOSIS;

ANIMALIA; CANIS FAMILIARIS; ORYCTOLAGUS CUNICULUS;

EID: 0034678840     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00097-4     Document Type: Article

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