메뉴 건너뛰기




Volumn 7, Issue 4, 2003, Pages 527-541

Molecular targets in the inhibition of angiogenesis

Author keywords

Antiangiogenic therapy; Tumour angiogenesis; Vascular endothelial growth factor (VEGF)

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 4 DEDIMETHYLAMINOSANCYCLINE; 5 AMINO 1 [3,5 DICHLORO 4 (4 CHLOROBENZOYL)BENZYL] 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; AE 941; ALPHA INTERFERON; ANGIOGENESIS INHIBITOR; ANGIOGENIC FACTOR; ANGIOPOIETIN 1; ANGIOPOIETIN 2; BEVACIZUMAB; CELECOXIB; CILENGITIDE; COLLAGEN; CYTOTOXIC AGENT; IM 862; INTEGRIN; INTERLEUKIN 12; MARIMASTAT; MATRIX METALLOPROTEINASE; MONOCLONAL ANTIBODY LM 609; PLASMINOGEN; REBIMASTAT; SQUALAMINE; THALIDOMIDE; THROMBOCYTE FACTOR 4; THROMBOSPONDIN; TUMOR NECROSIS FACTOR ALPHA; TYROSINE KINASE RECEPTOR; UNINDEXED DRUG; VASCULOTROPIN;

EID: 0042329420     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.7.4.527     Document Type: Review
Times cited : (15)

References (190)
  • 1
    • 0032322725 scopus 로고    scopus 로고
    • Hemangioblast development and regulation
    • CHOI K: Hemangioblast development and regulation. Biochem. Cell Biol. (1998) 76:947-956.
    • (1998) Biochem. Cell Biol. , vol.76 , pp. 947-956
    • Choi, K.1
  • 2
    • 0023913551 scopus 로고
    • Embryonic vascular development: Immunohistochemical identification of the origin and subsequent morphogenesis of the major vessel primordia in quail embryos
    • COFFIN JD, POOLE TJ: Embryonic vascular development: immunohistochemical identification of the origin and subsequent morphogenesis of the major vessel primordia in quail embryos. Development (1988) 102:735-748.
    • (1988) Development , vol.102 , pp. 735-748
    • Coffin, J.D.1    Poole, T.J.2
  • 3
    • 0024523907 scopus 로고
    • Relationship between vasculogenesis, angiogenesis and haemopoiesis during avian ontogeny
    • PARDANAUD L, YASSINE F, DIETERLEN-LIEVRE F: Relationship between vasculogenesis, angiogenesis and haemopoiesis during avian ontogeny. Development (1989) 105:473-485.
    • (1989) Development , vol.105 , pp. 473-485
    • Pardanaud, L.1    Yassine, F.2    Dieterlen-Lievre, F.3
  • 4
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • RISAU W: Mechanisms of angiogenesis. Nature (1997) 386:671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 5
    • 0014865863 scopus 로고
    • Population kinetics of carcinoma cells, capillary endothelial cells, and fibroblasts in a transplanted mouse mammary tumor
    • TANNOCK IF: Population kinetics of carcinoma cells, capillary endothelial cells, and fibroblasts in a transplanted mouse mammary tumor. Cancer Res. (1970) 30:2470-2476.
    • (1970) Cancer Res. , vol.30 , pp. 2470-2476
    • Tannock, I.F.1
  • 6
    • 0014824427 scopus 로고
    • Tumor growth and cell kinetics in chronically hypoxic animals
    • TANNOCK IF, STEEL GG: Tumor growth and cell kinetics in chronically hypoxic animals. J. Natl. Cancer Inst. (1970) 45:123-133.
    • (1970) J. Natl. Cancer Inst. , vol.45 , pp. 123-133
    • Tannock, I.F.1    Steel, G.G.2
  • 7
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • FOLKMAN J: Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. (1971) 285:1182-1186.
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 8
    • 0034684999 scopus 로고    scopus 로고
    • Initial stages of tumor cell-induced angiogenesis: Evaluation via skin window chambers in rodent models
    • LI CY, SHAN S, HUANG Q et al.: Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models. J. Natl. Cancer Inst. (2000) 92:143-147.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 143-147
    • Li, C.Y.1    Shan, S.2    Huang, Q.3
  • 9
    • 0016218630 scopus 로고
    • Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation
    • LIOTTA LA, KLEINERMAN J, SAIDEL GM: Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res. (1974) 34:997-1004.
    • (1974) Cancer Res. , vol.34 , pp. 997-1004
    • Liotta, L.A.1    Kleinerman, J.2    Saidel, G.M.3
  • 10
    • 0033529618 scopus 로고    scopus 로고
    • Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
    • ASAHARA T, MASUDA H, TAKAHASHI T et al.: Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ. Res. (1999) 85:221-228.
    • (1999) Circ. Res. , vol.85 , pp. 221-228
    • Asahara, T.1    Masuda, H.2    Takahashi, T.3
  • 11
    • 0034682892 scopus 로고    scopus 로고
    • Genes expressed in human tumor endothelium
    • ST CROIX B, RAGO C, VELCULESCU V et al.: Genes expressed in human tumor endothelium. Science (2000) 289:1197-1202.
    • (2000) Science , vol.289 , pp. 1197-1202
    • St Croix, B.1    Rago, C.2    Velculescu, V.3
  • 12
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis - Correlation in invasive breast carcinoma
    • WEIDNER N, SEMPLE JP, WELCH WR, FOLKMAN J: Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N. Engl. J. Med. (1991) 324:1-8.
    • (1991) N. Engl. J. Med. , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3    Folkman, J.4
  • 13
    • 0027043136 scopus 로고
    • Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma
    • WEIDNER N, FOLKMAN J, POZZA F et al.: Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J. Natl. Cancer Inst. (1992) 84:1875-1887.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 1875-1887
    • Weidner, N.1    Folkman, J.2    Pozza, F.3
  • 14
    • 0028939826 scopus 로고
    • Clinical importance of the determination of tumor angiogenesis in breast carcinoma: Much more than a new prognostic tool
    • GASPARINI G, HARRIS AL: Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. J. Clin. Oncol. (1995) 13:765-782.
    • (1995) J. Clin. Oncol. , vol.13 , pp. 765-782
    • Gasparini, G.1    Harris, A.L.2
  • 15
    • 0028469575 scopus 로고
    • [Tumoral vascular density in breast tumors and their effect on recurrence-free survival]
    • German
    • OBERMAIR A, CZERWENKA K, KURZ C, KAIDER A, SEVELDA P: [Tumoral vascular density in breast tumors and their effect on recurrence-free survival]. Chirurgie (1994) 65:611-615. German.
    • (1994) Chirurgie , vol.65 , pp. 611-615
    • Obermair, A.1    Czerwenka, K.2    Kurz, C.3    Kaider, A.4    Sevelda, P.5
  • 16
    • 0027373841 scopus 로고
    • Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma
    • TOI M, KASHITANI J, TOMINAGA T: Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma. Int. J. Cancer. (1993) 55:371-374.
    • (1993) Int. J. Cancer , vol.55 , pp. 371-374
    • Toi, M.1    Kashitani, J.2    Tominaga, T.3
  • 17
  • 18
    • 0026497186 scopus 로고
    • Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer
    • HORAK ER, LEEK R, KLENK N et al.: Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer. Lancet (1992) 340:1120-1124.
    • (1992) Lancet , vol.340 , pp. 1120-1124
    • Horak, E.R.1    Leek, R.2    Klenk, N.3
  • 21
    • 0029010325 scopus 로고
    • Tumor angiogenesis as a prognostic assay for invasive ductal breast carcinoma
    • AXELSSON K, LJUNG BM, MOORE DH II et al.: Tumor angiogenesis as a prognostic assay for invasive ductal breast carcinoma. J. Natl. Cancer Inst. (1995) 87:997-1008.
    • (1995) J. Natl. Cancer Inst. , vol.87 , pp. 997-1008
    • Axelsson, K.1    Ljung, B.M.2    Moore D.H. II3
  • 22
    • 0027717345 scopus 로고
    • Tumor angiogenesis correlates with metastases in invasive prostate carcinoma
    • WEIDNER N, CARROLL PR, FLAX J, BLUMENFELD W, FOLKMAN J: Tumor angiogenesis correlates with metastases in invasive prostate carcinoma. Am. J. Pathol. (1993) 143:401-409.
    • (1993) Am. J. Pathol. , vol.143 , pp. 401-409
    • Weidner, N.1    Carroll, P.R.2    Flax, J.3    Blumenfeld, W.4    Folkman, J.5
  • 23
    • 0027811085 scopus 로고
    • Tumor-associated angiogenesis in prostate cancer
    • FREGENE TA, KHANUJA PS, NOTO AC et al.: Tumor-associated angiogenesis in prostate cancer. Anticancer Res. (1993) 13:2377-2381.
    • (1993) Anticancer Res. , vol.13 , pp. 2377-2381
    • Fregene, T.A.1    Khanuja, P.S.2    Noto, A.C.3
  • 24
    • 0028049455 scopus 로고
    • Extent of vascularization as a prognostic indicator in thin (< 0.76 mm) malignant melanomas
    • GRAHAM CH, RIVERS J, KERBEL RS, STANKIEWICZ KS, WHITE WL: Extent of vascularization as a prognostic indicator in thin (< 0.76 mm) malignant melanomas. Am. J. Pathol. (1994) 145:510-514.
    • (1994) Am. J. Pathol. , vol.145 , pp. 510-514
    • Graham, C.H.1    Rivers, J.2    Kerbel, R.S.3    Stankiewicz, K.S.4    White, W.L.5
  • 26
    • 0029084797 scopus 로고
    • Tumour angiogenesis and tumour cell proliferation as prognostic indicators in gastric carcinoma
    • MAEDA K, CHUNG YS, TAKATSUKA S et al.: Tumour angiogenesis and tumour cell proliferation as prognostic indicators in gastric carcinoma. Br. J. Cancer (1995) 72:319-323.
    • (1995) Br. J. Cancer , vol.72 , pp. 319-323
    • Maeda, K.1    Chung, Y.S.2    Takatsuka, S.3
  • 27
    • 84970070220 scopus 로고
    • Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
    • TAKAHASHI Y, KITADAI Y, BUCANA CD, CLEARY KR, ELLIS LM: Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res. (1995) 55:3964-3968.
    • (1995) Cancer Res. , vol.55 , pp. 3964-3968
    • Takahashi, Y.1    Kitadai, Y.2    Bucana, C.D.3    Cleary, K.R.4    Ellis, L.M.5
  • 28
    • 0029988680 scopus 로고    scopus 로고
    • Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumour cell proliferation in human epidermoid lung carcinoma
    • MATTERN J, KOOMAGI R, VOLM M: Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumour cell proliferation in human epidermoid lung carcinoma. Br. J. Cancer (1996) 73:931-934.
    • (1996) Br. J. Cancer , vol.73 , pp. 931-934
    • Mattern, J.1    Koomagi, R.2    Volm, M.3
  • 29
    • 1842328560 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer
    • VOLM M, KOOMAGI R, MATTERN J: Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer. Int. J. Cancer (1997) 74:64-68.
    • (1997) Int. J. Cancer , vol.74 , pp. 64-68
    • Volm, M.1    Koomagi, R.2    Mattern, J.3
  • 30
    • 0030756796 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and its receptor correlate with angiogenesis and survival in pulmonary adenocarcinoma
    • TAKANAMI I, TANAKA F, HASHIZUME T, KODAIRA S: Vascular endothelial growth factor and its receptor correlate with angiogenesis and survival in pulmonary adenocarcinoma. Anticancer Res. (1997) 17:2811-2814.
    • (1997) Anticancer Res. , vol.17 , pp. 2811-2814
    • Takanami, I.1    Tanaka, F.2    Hashizume, T.3    Kodaira, S.4
  • 31
    • 0037134709 scopus 로고    scopus 로고
    • Clinical application of antiangiogenic therapy; microvessel density, what it does and doesn't tell us
    • HLATKY L, HAHNFELDT P, FOLKMAN J: Clinical application of antiangiogenic therapy; microvessel density, what it does and doesn't tell us. J. Natl. Cancer Inst. (2002) 94:883-893.
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 883-893
    • Hlatky, L.1    Hahnfeldt, P.2    Folkman, J.3
  • 32
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • HANAHAN D, FOLKMAN J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell (1996) 86:353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 33
    • 0024816246 scopus 로고
    • Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells
    • PLOUET J, SCHILLING J, GOSPODAROWICZ D: Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells. EMBO J. (1989) 8:3801-3806.
    • (1989) EMBO J. , vol.8 , pp. 3801-3806
    • Plouet, J.1    Schilling, J.2    Gospodarowicz, D.3
  • 34
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • SHWEIKI D, ITIN A, SOFFER D, KESHET E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature (1992) 359:843-845.
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 35
    • 0024337366 scopus 로고
    • EGF and TGF-α are potent chemoattractants for endothelial cells and EGF-like peptides are present at sites of tissue regeneration
    • GROTENDORST GR, SOMA Y, TAKEHARA K, CHARETTE M: EGF and TGF-α are potent chemoattractants for endothelial cells and EGF-like peptides are present at sites of tissue regeneration. J. Cell. Physiol. (1989) 139:617-623.
    • (1989) J. Cell. Physiol. , vol.139 , pp. 617-623
    • Grotendorst, G.R.1    Soma, Y.2    Takehara, K.3    Charette, M.4
  • 36
    • 0024436695 scopus 로고
    • Transforming growth factor β-1 positively modulates the bioactivity of fibroblast growth factor on corneal endothelial cells
    • PLOUET J, GOSPODAROWICZ D: Transforming growth factor β-1 positively modulates the bioactivity of fibroblast growth factor on corneal endothelial cells. J. Cell. Physiol. (1989) 141:392-399.
    • (1989) J. Cell. Physiol. , vol.141 , pp. 392-399
    • Plouet, J.1    Gospodarowicz, D.2
  • 37
    • 0027934320 scopus 로고
    • Interleukin-8 and tumor necrosis factor-α are involved in human aortic endothelial cell migration. The possible role of these cytokines in human aortic aneurysmal blood vessel growth
    • SZEKANECZ Z, SHAH MR, HARLOW LA, PEARCE WH, KOCH AE: Interleukin-8 and tumor necrosis factor-α are involved in human aortic endothelial cell migration. The possible role of these cytokines in human aortic aneurysmal blood vessel growth. Pathobiology (1994) 62:134-139.
    • (1994) Pathobiology , vol.62 , pp. 134-139
    • Szekanecz, Z.1    Shah, M.R.2    Harlow, L.A.3    Pearce, W.H.4    Koch, A.E.5
  • 38
    • 0001603840 scopus 로고
    • Angiogenin stimulates endothelial cell prostacyclin secretion by activation of phospholipase A2
    • BICKNELL R, VALLEE BL: Angiogenin stimulates endothelial cell prostacyclin secretion by activation of phospholipase A2. Proc. Natl. Acad. Sci. USA (1989) 86:1573-1577
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 1573-1577
    • Bicknell, R.1    Vallee, B.L.2
  • 39
    • 0028355888 scopus 로고
    • PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF β-receptors
    • BATTEGAY EJ, RUPP J, IRUELA-ARISPE L, SAGE EH, PECH M: PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF β-receptors. J. Cell Biol. (1994) 125:917-928.
    • (1994) J. Cell Biol. , vol.125 , pp. 917-928
    • Battegay, E.J.1    Rupp, J.2    Iruela-Arispe, L.3    Sage, E.H.4    Pech, M.5
  • 40
    • 0034763273 scopus 로고    scopus 로고
    • Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts, DU145 prostate cells and CHRF megakaryocytes
    • HUANG YQ, LI JJ, HU L, LEE M, KARPATKIN S: Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts, DU145 prostate cells and CHRF megakaryocytes. Thromb. Haemost. (2001) 86:1094-1098.
    • (2001) Thromb. Haemost. , vol.86 , pp. 1094-1098
    • Huang, Y.Q.1    Li, J.J.2    Hu, L.3    Lee, M.4    Karpatkin, S.5
  • 41
    • 0030460424 scopus 로고    scopus 로고
    • Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
    • DAVIS S, ALDRICH TH, JONES PF et al.: Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell (1996) 87:1161-1169.
    • (1996) Cell , vol.87 , pp. 1161-1169
    • Davis, S.1    Aldrich, T.H.2    Jones, P.F.3
  • 42
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • FERRARA N, DAVIS-SMYTH T: The biology of vascular endothelial growth factor. Endocr. Rev. (1997) 18:4-25.
    • (1997) Endocr. Rev. , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 43
    • 0028147863 scopus 로고
    • Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo
    • MINCHENKO A, BAUER T, SALCEDA S, CARO J: Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo. Lab. Invest. (1994) 71:374-379.
    • (1994) Lab. Invest. , vol.71 , pp. 374-379
    • Minchenko, A.1    Bauer, T.2    Salceda, S.3    Caro, J.4
  • 44
    • 0029103274 scopus 로고
    • Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer
    • LIU Y, COX SR, MORITA T, KOUREMBANAS S: Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer. Circ. Res. (1995) 77:638-643.
    • (1995) Circ. Res. , vol.77 , pp. 638-643
    • Liu, Y.1    Cox, S.R.2    Morita, T.3    Kourembanas, S.4
  • 45
    • 0028897916 scopus 로고
    • Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor
    • FINKENZELLER G, TECHNAU A, MARME D: Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor. Biochem. Biophys. Res. Commun. (1995) 208:432-439.
    • (1995) Biochem. Biophys. Res. Commun. , vol.208 , pp. 432-439
    • Finkenzeller, G.1    Technau, A.2    Marme, D.3
  • 46
    • 0029068339 scopus 로고
    • Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation
    • MUKHOPADHYAY D, TSIOKAS L, ZHOU XM, FOSTER D, BRUGGE JS, SUKHATME VP: Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature (1995) 375:577-581.
    • (1995) Nature , vol.375 , pp. 577-581
    • Mukhopadhyay, D.1    Tsiokas, L.2    Zhou, X.M.3    Foster, D.4    Brugge, J.S.5    Sukhatme, V.P.6
  • 47
    • 0029681933 scopus 로고    scopus 로고
    • Mono-ADP-ribosylation: A reversible posttranslational modification of proteins
    • OKAZAKI IJ, MOSS J: Mono-ADP-ribosylation: a reversible posttranslational modification of proteins. Adv. Pharmacol. (1996) 35:247-280.
    • (1996) Adv. Pharmacol. , vol.35 , pp. 247-280
    • Okazaki, I.J.1    Moss, J.2
  • 48
    • 0027412319 scopus 로고
    • Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: A model of glioblastoma multiforme pathophysiology
    • GOLDMAN CK, KIM J, WONG WL, KING V, BROCK T, GILLESPIE GY: Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol. Biol. Cell. (1993) 4:121-133.
    • (1993) Mol. Biol. Cell. , vol.4 , pp. 121-133
    • Goldman, C.K.1    Kim, J.2    Wong, W.L.3    King, V.4    Brock, T.5    Gillespie, G.Y.6
  • 49
    • 0029805574 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma
    • WARREN RS, YUAN H, MATLI MR, FERRARA N, DONNER DB: Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma. J. Biol. Chem. (1996) 271:29483-29488.
    • (1996) J. Biol. Chem. , vol.271 , pp. 29483-29488
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3    Ferrara, N.4    Donner, D.B.5
  • 50
    • 0030046481 scopus 로고    scopus 로고
    • Interleukin 6 induces the expression of vascular endothelial growth factor
    • COHEN T, NAHARI D, CEREM LW, NEUFELD G, LEVI BZ: Interleukin 6 induces the expression of vascular endothelial growth factor. J. Biol. Chem. (1996) 271:736-741.
    • (1996) J. Biol. Chem. , vol.271 , pp. 736-741
    • Cohen, T.1    Nahari, D.2    Cerem, L.W.3    Neufeld, G.4    Levi, B.Z.5
  • 51
    • 0028804682 scopus 로고
    • Induction of vascular endothelial growth factor gene expression by interleukin-1 β in rat aortic smooth muscle cells
    • LI J, PERRELLA MA, TSAI JC et al.: Induction of vascular endothelial growth factor gene expression by interleukin-1 β in rat aortic smooth muscle cells. J. Biol. Chem. (1995) 270:308-312.
    • (1995) J. Biol. Chem. , vol.270 , pp. 308-312
    • Li, J.1    Perrella, M.A.2    Tsai, J.C.3
  • 52
    • 0028822834 scopus 로고
    • Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
    • RAK J, MITSUHASHI Y, BAYKO L et al.: Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res. (1995) 55:4575-4580.
    • (1995) Cancer Res. , vol.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhashi, Y.2    Bayko, L.3
  • 53
    • 0028865988 scopus 로고
    • Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression
    • MUKHOPADHYAY D, TSIOKAS L, SUKHATME VP: Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res. (1995) 55:6161-6165.
    • (1995) Cancer Res. , vol.55 , pp. 6161-6165
    • Mukhopadhyay, D.1    Tsiokas, L.2    Sukhatme, V.P.3
  • 54
    • 0025147371 scopus 로고
    • A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin
    • GOOD DJ, POLVERINI PJ, RASTINEJAD F et al.: A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc. Natl. Acad. Sci. USA (1990) 87:6624-6628.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6624-6628
    • Good, D.J.1    Polverini, P.J.2    Rastinejad, F.3
  • 55
    • 0025949596 scopus 로고
    • The 16K fragment of prolactin specifically inhibits basal or fibroblast growth factor stimulated growth of capillary endothelial cells
    • FERRARA N, CLAPP C, WEINER R: The 16K fragment of prolactin specifically inhibits basal or fibroblast growth factor stimulated growth of capillary endothelial cells. Endocrinology (1991) 129:896-900.
    • (1991) Endocrinology , vol.129 , pp. 896-900
    • Ferrara, N.1    Clapp, C.2    Weiner, R.3
  • 56
    • 0025166396 scopus 로고
    • Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides
    • MAIONE TE, GRAY GS, PETRO J et al.: Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. Science (1990) 247:77-79.
    • (1990) Science , vol.247 , pp. 77-79
    • Maione, T.E.1    Gray, G.S.2    Petro, J.3
  • 57
    • 0027970092 scopus 로고
    • Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
    • O'REILLY MS, HOLMGREN L, SHING Y et al.: Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell (1994) 79:315-328.
    • (1994) Cell , vol.79 , pp. 315-328
    • O'Reilly, M.S.1    Holmgren, L.2    Shing, Y.3
  • 58
    • 0031454617 scopus 로고    scopus 로고
    • Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
    • O'REILLY MS, BOEHM T, SHING Y et al.: Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell (1997) 88:277-285.
    • (1997) Cell , vol.88 , pp. 277-285
    • O'Reilly, M.S.1    Boehm, T.2    Shing, Y.3
  • 59
    • 0033578910 scopus 로고    scopus 로고
    • Antiangiogenic activity of the cleaved conformation of the serpin antithrombin
    • O'REILLY MS, PIRIE-SHEPHERD S, LANE WS, FOLKMAN J: Antiangiogenic activity of the cleaved conformation of the serpin antithrombin. Science (1999) 285:1926-1928.
    • (1999) Science , vol.285 , pp. 1926-1928
    • O'Reilly, M.S.1    Pirie-shepherd, S.2    Lane, W.S.3    Folkman, J.4
  • 60
    • 0028606364 scopus 로고
    • Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells
    • UEBA T, NOSAKA T, TAKAHASHI JA et al.: Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells. Proc. Natl. Acad. Sci. USA (1994) 91:9009-9013.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9009-9013
    • Ueba, T.1    Nosaka, T.2    Takahashi, J.A.3
  • 61
    • 0028060380 scopus 로고
    • Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
    • DAMERON KM, VOLPERT OV, TAINSKY MA, BOUCK N: Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science (1994) 265:1582-1584.
    • (1994) Science , vol.265 , pp. 1582-1584
    • Dameron, K.M.1    Volpert, O.V.2    Tainsky, M.A.3    Bouck, N.4
  • 62
    • 0036531949 scopus 로고    scopus 로고
    • What do oncogenic mutations have to do with angiogenesis/vascular dependence of tumors?
    • RAK J, YU JL, KERBEL RS, COOMBER BL: What do oncogenic mutations have to do with angiogenesis/vascular dependence of tumors? Cancer Res. (2002) 62:1931-1934.
    • (2002) Cancer Res. , vol.62 , pp. 1931-1934
    • Rak, J.1    Yu, J.L.2    Kerbel, R.S.3    Coomber, B.L.4
  • 63
    • 0025717523 scopus 로고
    • Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
    • KERBEL RS: Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. Bioessays (1991) 13:31-36.
    • (1991) Bioessays , vol.13 , pp. 31-36
    • Kerbel, R.S.1
  • 65
    • 0033592960 scopus 로고    scopus 로고
    • The onset and extent of genomic instability in sporadic colorectal tumor progression
    • STOLER DL, CHEN N, BASIK M et al.: The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc. Natl. Acad. Sci. USA (1999) 96:15121-15126.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 15121-15126
    • Stoler, D.L.1    Chen, N.2    Basik, M.3
  • 66
    • 0031469819 scopus 로고    scopus 로고
    • Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    • BOEHM T, FOLKMAN J, BROWDER T, O'REILLY MS: Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature (1997) 390:404-407.
    • (1997) Nature , vol.390 , pp. 404-407
    • Boehm, T.1    Folkman, J.2    Browder, T.3    O'Reilly, M.S.4
  • 67
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • GORRE ME, MOHAMMED M, ELLWOOD K et al.: Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science (2001) 293:876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 68
    • 0035819527 scopus 로고    scopus 로고
    • Development of matrix metalloproteinase inhibitors in cancer therapy
    • HIDALGO M, ECKHARDT SG: Development of matrix metalloproteinase inhibitors in cancer therapy. J. Natl. Cancer Inst. (2001) 93:178-193.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 178-193
    • Hidalgo, M.1    Eckhardt, S.G.2
  • 69
    • 0035721955 scopus 로고    scopus 로고
    • Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis
    • PEPPER MS: Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis. Arterioscler. Thromb. Vasc. Biol. (2001) 21:1104-1117.
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 1104-1117
    • Pepper, M.S.1
  • 70
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
    • COUSSENS LM, FINGLETON B, MATRISIAN LM: Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science (2002) 295:2387-2392.
    • (2002) Science , vol.295 , pp. 2387-2392
    • Coussens, L.M.1    Fingleton, B.2    Matrisian, L.M.3
  • 71
    • 0029021904 scopus 로고
    • Endothelial receptor tyrosine kinases involved in angiogenesis
    • MUSTONEN T, ALITALO K: Endothelial receptor tyrosine kinases involved in angiogenesis. J. Cell Biol. (1995) 129:895-898.
    • (1995) J. Cell Biol. , vol.129 , pp. 895-898
    • Mustonen, T.1    Alitalo, K.2
  • 72
    • 0034674108 scopus 로고    scopus 로고
    • Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165
    • [corrected]
    • GLUZMAN-POLTORAK Z, COHEN T, HERZOG Y, NEUFELD G: Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]. J. Biol. Chem. (2000) 275:18040-18045.
    • (2000) J. Biol. Chem. , vol.275 , pp. 18040-18045
    • Gluzman-Poltorak, Z.1    Cohen, T.2    Herzog, Y.3    Neufeld, G.4
  • 74
    • 0036491615 scopus 로고    scopus 로고
    • VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis
    • INOUE M, HAGER JH, FERRARA N, GERBER HP, HANAHAN D: VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis. Cancer Cell (2002) 1:193-202.
    • (2002) Cancer Cell , vol.1 , pp. 193-202
    • Inoue, M.1    Hager, J.H.2    Ferrara, N.3    Gerber, H.P.4    Hanahan, D.5
  • 75
    • 0035187771 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Its prognostic, predictive, and therapeutic implications
    • TOI M, MATSUMOTO T, BANDO H: Vascular endothelial growth factor: its prognostic, predictive, and therapeutic implications. Lancet Oncol. (2001) 2:667-673.
    • (2001) Lancet Oncol. , vol.2 , pp. 667-673
    • Toi, M.1    Matsumoto, T.2    Bando, H.3
  • 76
    • 0033521040 scopus 로고    scopus 로고
    • Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis
    • YONEKURA H, SAKURAI S, LIU X et al.: Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. J. Biol. Chem. (1999) 274:35172-35178.
    • (1999) J. Biol. Chem. , vol.274 , pp. 35172-35178
    • Yonekura, H.1    Sakurai, S.2    Liu, X.3
  • 77
    • 0035114105 scopus 로고    scopus 로고
    • Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis
    • HIRATSUKA S, MARU Y, OKADA A, SEIKI M, NODA T, SHIBUYA M: Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. Cancer Res. (2001) 61:1207-1213.
    • (2001) Cancer Res. , vol.61 , pp. 1207-1213
    • Hiratsuka, S.1    Maru, Y.2    Okada, A.3    Seiki, M.4    Noda, T.5    Shibuya, M.6
  • 78
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    • PARK JE, CHEN HH, WINER J, HOUCK KA, FERRARA N: Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J. Biol. Chem. (1994) 269:25646-25654.
    • (1994) J. Biol. Chem. , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3    Houck, K.A.4    Ferrara, N.5
  • 79
    • 0036344495 scopus 로고    scopus 로고
    • Revascularization of ischemic tissues by P1GF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
    • LUTTUN A, TJWA M, MOONS L et al.: Revascularization of ischemic tissues by P1GF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. (2002) 8:831-840.
    • (2002) Nat. Med. , vol.8 , pp. 831-840
    • Luttun, A.1    Tjwa, M.2    Moons, L.3
  • 80
    • 0037438583 scopus 로고    scopus 로고
    • A critical role of placental growth factor in the induction of inflammation and edema formation
    • OURA H, BERTONCINI J, VELASCO P, BROWN LF, CARMELIET P, DETMAR M: A critical role of placental growth factor in the induction of inflammation and edema formation. Blood (2003) 101:560-567.
    • (2003) Blood , vol.101 , pp. 560-567
    • Oura, H.1    Bertoncini, J.2    Velasco, P.3    Brown, L.F.4    Carmeliet, P.5    Detmar, M.6
  • 81
    • 18444413531 scopus 로고    scopus 로고
    • Loss of placental growth factor protects mice against vascular permeability in pathological conditions
    • LUTTUN A, BRUSSELMANS K, FUKAO H et al.: Loss of placental growth factor protects mice against vascular permeability in pathological conditions. Biochem. Biophys. Res. Commun. (2002) 295:428-434.
    • (2002) Biochem. Biophys. Res. Commun. , vol.295 , pp. 428-434
    • Luttun, A.1    Brusselmans, K.2    Fukao, H.3
  • 83
    • 0034737422 scopus 로고    scopus 로고
    • Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway
    • PAPAPETROPOULOS A, FULTON D, MAHBOUBI K et al.: Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway. J. Biol. Chem. (2000) 275:9102-9105.
    • (2000) J. Biol. Chem. , vol.275 , pp. 9102-9105
    • Papapetropoulos, A.1    Fulton, D.2    Mahboubi, K.3
  • 84
    • 0036405427 scopus 로고    scopus 로고
    • Angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice
    • SHIM WS, TEH M, BAPNA A et al.: Angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice. Exp. Cell Res. (2002) 279:299-309.
    • (2002) Exp. Cell Res. , vol.279 , pp. 299-309
    • Shim, W.S.1    Teh, M.2    Bapna, A.3
  • 85
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    • MAISONPIERRE PC, SURI C, JONES PF et al.: Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science (1997) 277:55-60.
    • (1997) Science , vol.277 , pp. 55-60
    • Maisonpierre, P.C.1    Suri, C.2    Jones, P.F.3
  • 86
    • 0033580889 scopus 로고    scopus 로고
    • Vessel co-option, regression, and growth in tumors mediated by angiopoietins and VEGF
    • HOLASH J, MAISONPIERRE PC, COMPTON D et al.: Vessel co-option, regression, and growth in tumors mediated by angiopoietins and VEGF. Science (1999) 284:1994-1998.
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1    Maisonpierre, P.C.2    Compton, D.3
  • 87
    • 0036896832 scopus 로고    scopus 로고
    • Expression of angiopoietins and its clinical significance in non-small cell lung cancer
    • TANAKA F, ISHIKAWA S, YANAGIHARA K et al.: Expression of angiopoietins and its clinical significance in non-small cell lung cancer. Cancer Res. (2002) 62:7124-7129.
    • (2002) Cancer Res. , vol.62 , pp. 7124-7129
    • Tanaka, F.1    Ishikawa, S.2    Yanagihara, K.3
  • 88
    • 0025767622 scopus 로고
    • Inhibition of tumor growth in mice by an analogue of platelet factor 4 that lacks affinity for heparin and retains potent angiostatic activity
    • MAIONE TE, GRAY GS, HUNT AJ, SHARPE RJ: Inhibition of tumor growth in mice by an analogue of platelet factor 4 that lacks affinity for heparin and retains potent angiostatic activity. Cancer Res. (1991) 51:2077-2083.
    • (1991) Cancer Res. , vol.51 , pp. 2077-2083
    • Maione, T.E.1    Gray, G.S.2    Hunt, A.J.3    Sharpe, R.J.4
  • 89
    • 0029025873 scopus 로고
    • Platelet factor-4 inhibits the mitogenic activity of VEGF121 and VEGF165 using several concurrent mechanisms
    • GENGRINOVITCH S, GREENBERG SM, COHEN T et al.: Platelet factor-4 inhibits the mitogenic activity of VEGF121 and VEGF165 using several concurrent mechanisms. J. Biol. Chem. (1995) 270:15059-15065.
    • (1995) J. Biol. Chem. , vol.270 , pp. 15059-15065
    • Gengrinovitch, S.1    Greenberg, S.M.2    Cohen, T.3
  • 90
    • 2642708372 scopus 로고    scopus 로고
    • Platelet factor 4 modulates fibroblast growth factor 2 (FGF-2) activity and inhibits FGF-2 dimerization
    • PEROLLET C, HAN ZC, SAVONA C, CAEN JP, BIKFALVI A: Platelet factor 4 modulates fibroblast growth factor 2 (FGF-2) activity and inhibits FGF-2 dimerization. Blood (1998) 91:3289-3299.
    • (1998) Blood , vol.91 , pp. 3289-3299
    • Perollet, C.1    Han, Z.C.2    Savona, C.3    Caen, J.P.4    Bikfalvi, A.5
  • 91
    • 0035929606 scopus 로고    scopus 로고
    • Solution structure and interaction with basic and acidic fibroblast growth factor of a 3 kDa human platelet factor-4 fragment with antiangiogenic activity
    • LOZANO RM, REDONDO-HORCAJO M, JIMENEZ MA et al.: Solution structure and interaction with basic and acidic fibroblast growth factor of a 3 kDa human platelet factor-4 fragment with antiangiogenic activity. J. Biol. Chem. (2001) 276:35723-35734.
    • (2001) J. Biol. Chem. , vol.276 , pp. 35723-35734
    • Lozano, R.M.1    Redondo-Horcajo, M.2    Jimenez, M.A.3
  • 92
    • 0033179161 scopus 로고    scopus 로고
    • Inhibition of in vitro angiogenesis by platelet factor-4-derived peptides and mechanism of action
    • JOUAN V, CANRON X, ALEMANY M et al.: Inhibition of in vitro angiogenesis by platelet factor-4-derived peptides and mechanism of action. Blood (1999) 94:984-993.
    • (1999) Blood , vol.94 , pp. 984-993
    • Jouan, V.1    Canron, X.2    Alemany, M.3
  • 93
    • 0032910176 scopus 로고    scopus 로고
    • Inhibition of human umbilical vein endothelial cell proliferation by the CXC chemokine, platelet factor 4 (PF4), is associated with impaired downregulation of p21(Cip1/WAF1)
    • GENTILINI G, KIRSCHBAUM NE, AUGUSTINE JA, ASTER RH, VISENTIN GP: Inhibition of human umbilical vein endothelial cell proliferation by the CXC chemokine, platelet factor 4 (PF4), is associated with impaired downregulation of p21(Cip1/WAF1). Blood (1999) 93:25-33.
    • (1999) Blood , vol.93 , pp. 25-33
    • Gentilini, G.1    Kirschbaum, N.E.2    Augustine, J.A.3    Aster, R.H.4    Visentin, G.P.5
  • 96
    • 0035821779 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1
    • JIMENEZ B, VOLPERT OV, REIHER F et al.: c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1. Oncogene (2001) 20:3443-3448.
    • (2001) Oncogene , vol.20 , pp. 3443-3448
    • Jimenez, B.1    Volpert, O.V.2    Reiher, F.3
  • 97
    • 0033613226 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the Type 1 repeats
    • IRUELA-ARISPE ML, LOMBARDO M, KRUTZSCH HC, LAWLER J, ROBERTS DD: Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the Type 1 repeats. Circulation (1999) 100:1423-1431.
    • (1999) Circulation , vol.100 , pp. 1423-1431
    • Iruela-Arispe, M.L.1    Lombardo, M.2    Krutzsch, H.C.3    Lawler, J.4    Roberts, D.D.5
  • 98
    • 0034644748 scopus 로고    scopus 로고
    • Thrombospondin Type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity
    • BEIN K, SIMONS M: Thrombospondin Type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity. J. Biol. Chem. (2000) 275:32167-32173.
    • (2000) J. Biol. Chem. , vol.275 , pp. 32167-32173
    • Bein, K.1    Simons, M.2
  • 100
    • 0034993498 scopus 로고    scopus 로고
    • In vivo mechanisms by which tumors producing thrombospondin 1 bypass its inhibitory effects
    • FILLEUR S, VOLPERT OV, DEGEORGES A et al.: In vivo mechanisms by which tumors producing thrombospondin 1 bypass its inhibitory effects. Genes Dev. (2001) 15:1373-1382.
    • (2001) Genes Dev. , vol.15 , pp. 1373-1382
    • Filleur, S.1    Volpert, O.V.2    Degeorges, A.3
  • 101
    • 0033593014 scopus 로고    scopus 로고
    • Thrombospondin-2: A potent endogenous inhibitor of tumor growth and angiogenesis
    • STREIT M, RICCARDI L, VELASCO P et al.: Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis. Proc. Natl. Acad. Sci. USA (1999) 96:14888-14893.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 14888-14893
    • Streit, M.1    Riccardi, L.2    Velasco, P.3
  • 103
    • 0033554723 scopus 로고    scopus 로고
    • Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
    • LYDEN D, YOUNG AZ, ZAGZAG D et al.: Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature (1999) 401:670-677.
    • (1999) Nature , vol.401 , pp. 670-677
    • Lyden, D.1    Young, A.Z.2    Zagzag, D.3
  • 104
    • 0035924693 scopus 로고    scopus 로고
    • The Id proteins and angiogenesis
    • BENEZRA R, RAFII S, LYDEN D: The Id proteins and angiogenesis. Oncogene (2001) 20:8334-8341.
    • (2001) Oncogene , vol.20 , pp. 8334-8341
    • Benezra, R.1    Rafii, S.2    Lyden, D.3
  • 106
    • 0025195196 scopus 로고
    • 2(+)-dependent cell - Cell adhesion molecule in endothelial cells
    • 2(+)-dependent cell - cell adhesion molecule in endothelial cells. J. Cell Biol. (1990) 110:1745-1756.
    • (1990) J. Cell Biol. , vol.110 , pp. 1745-1756
    • Heimark, R.L.1    Degner, M.2    Schwartz, S.M.3
  • 107
    • 0026013429 scopus 로고
    • The role of integrins in the maintenance of endothelial monolayer integrity
    • LAMPUGNANI MG, RESNATI M, DEJANA E, MARCHISIO PC: The role of integrins in the maintenance of endothelial monolayer integrity. J. Cell Biol. (1991) 112:479-490.
    • (1991) J. Cell Biol. , vol.112 , pp. 479-490
    • Lampugnani, M.G.1    Resnati, M.2    Dejana, E.3    Marchisio, P.C.4
  • 108
    • 0035964805 scopus 로고    scopus 로고
    • Integrins in vascular development
    • RUPP PA, LITTLE CD: Integrins in vascular development. Circ. Res. (2001) 89:566-572.
    • (2001) Circ. Res. , vol.89 , pp. 566-572
    • Rupp, P.A.1    Little, C.D.2
  • 110
    • 0036734093 scopus 로고    scopus 로고
    • A reevaluation of integrins as regulators of angiogenesis
    • HYNES RO: A reevaluation of integrins as regulators of angiogenesis. Nat. Med. (2002) 8:918-921.
    • (2002) Nat. Med. , vol.8 , pp. 918-921
    • Hynes, R.O.1
  • 111
    • 0036156813 scopus 로고    scopus 로고
    • Integrin indecision
    • CARMELIET P: Integrin indecision. Nat. Med. (2002) 8:14-16.
    • (2002) Nat. Med. , vol.8 , pp. 14-16
    • Carmeliet, P.1
  • 113
    • 0037016498 scopus 로고    scopus 로고
    • Tumstatin, an endothelial cell-specific inhibitor of protein synthesis
    • MAESHIMA Y, SUDHAKAR A, LIVELY JC et al.: Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science (2002) 295:140-143.
    • (2002) Science , vol.295 , pp. 140-143
    • Maeshima, Y.1    Sudhakar, A.2    Lively, J.C.3
  • 114
    • 15444352707 scopus 로고    scopus 로고
    • Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9)
    • PATTERSON BC, SANG QA: Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/type IV collagenase (MMP-9). J. Biol. Chem. (1997) 272:28823-28825.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28823-28825
    • Patterson, B.C.1    Sang, Q.A.2
  • 115
    • 0030998660 scopus 로고    scopus 로고
    • Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma
    • DONG Z, KUMAR R, YANG X, FIDLER IJ: Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma. Cell (1997) 88:801-810.
    • (1997) Cell , vol.88 , pp. 801-810
    • Dong, Z.1    Kumar, R.2    Yang, X.3    Fidler, I.J.4
  • 116
    • 12644251975 scopus 로고    scopus 로고
    • The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin
    • GATELY S, TWARDOWSKI P, STACK MS et al.: The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin. Proc. Natl. Acad. Sci. USA (1997) 94:10868-10872.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10868-10872
    • Gately, S.1    Twardowski, P.2    Stack, M.S.3
  • 118
    • 0034963151 scopus 로고    scopus 로고
    • Angiostatin effects on endothelial cells mediated by ceramide and RhoA
    • GUPTA N, NODZENSKI E, KHODAREV NN et al.: Angiostatin effects on endothelial cells mediated by ceramide and RhoA. EMBO Rep. (2001) 2:536-540.
    • (2001) EMBO Rep. , vol.2 , pp. 536-540
    • Gupta, N.1    Nodzenski, E.2    Khodarev, N.N.3
  • 119
    • 0034714438 scopus 로고    scopus 로고
    • Cytoskeletal disruption accelerates caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis
    • YAMAZAKI Y, TSURUGA M, ZHOU D et al.: Cytoskeletal disruption accelerates caspase-3 activation and alters the intracellular membrane reorganization in DNA damage-induced apoptosis. Exp. Cell Res. (2000) 259:64-78.
    • (2000) Exp. Cell Res. , vol.259 , pp. 64-78
    • Yamazaki, Y.1    Tsuruga, M.2    Zhou, D.3
  • 120
    • 0035810936 scopus 로고    scopus 로고
    • Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin
    • MOSER TL, KENAN DJ, ASHLEY TA et al.: Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin. Proc. Natl. Acad. Sci. USA (2001) 98:6656-6661.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6656-6661
    • Moser, T.L.1    Kenan, D.J.2    Ashley, T.A.3
  • 121
    • 0034581338 scopus 로고    scopus 로고
    • Effects of microenvironmental extracellular pH and extracellular matrix proteins on angiostatin's activity and on intracellular pH
    • WAHL ML, GRANT DS: Effects of microenvironmental extracellular pH and extracellular matrix proteins on angiostatin's activity and on intracellular pH. Gen. Pharmacol. (2000) 35:277-285.
    • (2000) Gen. Pharmacol. , vol.35 , pp. 277-285
    • Wahl, M.L.1    Grant, D.S.2
  • 122
    • 0036479785 scopus 로고    scopus 로고
    • Neutrophils as a key cellular target for angiostatin: Implications for regulation of angiogenesis and inflammation
    • BENELLI R, MORINI M, CARROZZINO F et al.: Neutrophils as a key cellular target for angiostatin: implications for regulation of angiogenesis and inflammation. FASEB J. (2002) 16:267-269.
    • (2002) FASEB J. , vol.16 , pp. 267-269
    • Benelli, R.1    Morini, M.2    Carrozzino, F.3
  • 124
    • 0032536859 scopus 로고    scopus 로고
    • Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution
    • HOHENESTER E, SASAKI T, OLSEN BR, TIMPL R: Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution. EMBO J. (1998) 17:1656-1664.
    • (1998) EMBO J. , vol.17 , pp. 1656-1664
    • Hohenester, E.1    Sasaki, T.2    Olsen, B.R.3    Timpl, R.4
  • 125
    • 0033575658 scopus 로고    scopus 로고
    • Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding
    • YAMAGUCHI N, ANAND-APTE B, LEE M et al.: Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding. EMBO J. (1999) 18:4414-4423.
    • (1999) EMBO J. , vol.18 , pp. 4414-4423
    • Yamaguchi, N.1    Anand-Apte, B.2    Lee, M.3
  • 126
    • 0035045114 scopus 로고    scopus 로고
    • Lack of antitumor activity of recombinant endostatin in a human neuroblastoma xenograft model
    • JOUANNEAU E, ALBERTI L, NEJJARI M et al.: Lack of antitumor activity of recombinant endostatin in a human neuroblastoma xenograft model. J. Neurooncol. (2001) 51:11-18.
    • (2001) J. Neurooncol. , vol.51 , pp. 11-18
    • Jouanneau, E.1    Alberti, L.2    Nejjari, M.3
  • 128
    • 0035186865 scopus 로고    scopus 로고
    • Thalidomide and its analogues inhibit lipopolysaccharide-mediated induction of cyclooxygenase-2
    • FUJITA J, MESTRE JR, ZELDIS JB, SUBBARAMAIAH K, DANNENBERG AJ: Thalidomide and its analogues inhibit lipopolysaccharide-mediated induction of cyclooxygenase-2. Clin. Cancer Res. (2001) 7:3349-3355.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3349-3355
    • Fujita, J.1    Mestre, J.R.2    Zeldis, J.B.3    Subbaramaiah, K.4    Dannenberg, A.J.5
  • 129
    • 0036891109 scopus 로고    scopus 로고
    • Antitumor efficacy of conventional anticancer drugs is enhanced by the vascular targeting agent ZD6126
    • SIEMANN DW, ROJIANI AM: Antitumor efficacy of conventional anticancer drugs is enhanced by the vascular targeting agent ZD6126. Int. J. Radiat. Oncol. Biol. Phys. (2002) 54:1512-1517.
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.54 , pp. 1512-1517
    • Siemann, D.W.1    Rojiani, A.M.2
  • 130
    • 0036568457 scopus 로고    scopus 로고
    • Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy
    • SIEMANN DW, MERCER E, LEPLER S, ROJIANI AM: Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy. Int. J. Cancer (2002) 99:1-6.
    • (2002) Int. J. Cancer , vol.99 , pp. 1-6
    • Siemann, D.W.1    Mercer, E.2    Lepler, S.3    Rojiani, A.M.4
  • 131
    • 0033119771 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues
    • TOZER GM, PRISE VE, WILSON J et al.: Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues. Cancer Res. (1999) 59:1626-1634.
    • (1999) Cancer Res. , vol.59 , pp. 1626-1634
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3
  • 133
    • 0028951043 scopus 로고
    • Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
    • HOLMGREN L, O'REILLY MS, FOLKMAN J: Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat. Med. (1995) 1:149-153.
    • (1995) Nat. Med. , vol.1 , pp. 149-153
    • Holmgren, L.1    O'reilly, M.S.2    Folkman, J.3
  • 134
    • 0035187305 scopus 로고    scopus 로고
    • Tissue examination to monitor antiangiogenic therapy: A Phase I clinical trial with endostatin
    • MUNDHENKE C, THOMAS JP, WILDING G et al.: Tissue examination to monitor antiangiogenic therapy: a Phase I clinical trial with endostatin. Clin. Cancer Res. (2001) 7:3366-3374.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3366-3374
    • Mundhenke, C.1    Thomas, J.P.2    Wilding, G.3
  • 135
    • 0037106261 scopus 로고    scopus 로고
    • Phase I study of recombinant human endostatin in patients with advanced solid tumors
    • HERBST RS, HESS KR, TRAN HT et al.: Phase I study of recombinant human endostatin in patients with advanced solid tumors. J. Clin. Oncol. (2002) 20:3792-3803.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3792-3803
    • Herbst, R.S.1    Hess, K.R.2    Tran, H.T.3
  • 136
    • 0037106508 scopus 로고    scopus 로고
    • Phase I clinical trial of recombinant human endostatin administered as a short intravenous infusion repeated daily
    • EDER JP Jr, SUPKO JG, CLARK JW et al.: Phase I clinical trial of recombinant human endostatin administered as a short intravenous infusion repeated daily. J. Clin. Oncol. (2002) 20:3772-3784.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3772-3784
    • Eder J.P., Jr.1    Supko, J.G.2    Clark, J.W.3
  • 137
    • 0035424135 scopus 로고    scopus 로고
    • Marimastat as first-line therapy for patients with unresectable pancreatic cancer: A randomized trial
    • BRAMHALL SR, ROSEMURGY A, BROWN PD, BOWRY C, BUCKELS JA: Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial. J. Clin. Oncol. (2001) 19:3447-3455.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3447-3455
    • Bramhall, S.R.1    Rosemurgy, A.2    Brown, P.D.3    Bowry, C.4    Buckels, J.A.5
  • 138
    • 0000397265 scopus 로고    scopus 로고
    • A randomized Phase II trial comparing recombinant humanized monoclonal antibody to vascular endothelial growth factor plus carboplatin/paclitaxel (CP) to CP alone in patients with stage IIIB/IV NSCLC
    • Abstract 1896
    • DEVORE R, FAHRENBACHER L, HERBST R: A randomized Phase II trial comparing recombinant humanized monoclonal antibody to vascular endothelial growth factor plus carboplatin/paclitaxel (CP) to CP alone in patients with stage IIIB/IV NSCLC. Proc. Am. Soc. Oncol. (2000). Abstract 1896, 485a.
    • (2000) Proc. Am. Soc. Oncol.
    • Devore, R.1    Fahrenbacher, L.2    Herbst, R.3
  • 139
    • 0003170893 scopus 로고    scopus 로고
    • A Phase II trial of single agent recombinant humanized monoclonal antibody to vascular endothelial growth factor in patients with relapsed metastatic breast cancer
    • Abstract 5c
    • SLEDGE G, MILLER K, NOVOTNY W, GAUDREAULT J, ASH M, COBLEIGH M: A Phase II trial of single agent recombinant humanized monoclonal antibody to vascular endothelial growth factor in patients with relapsed metastatic breast cancer. Proc. Am. Soc. Clin. Oncol. (2000) 19. Abstract 5c, 3a.
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Sledge, G.1    Miller, K.2    Novotny, W.3    Gaudreault, J.4    Ash, M.5    Cobleigh, M.6
  • 140
    • 0003348278 scopus 로고    scopus 로고
    • A Phase II trial of humanized monoclonal anti-vascular endothelial growth factor antibody in hormone refractory prostate cancer
    • Abstract 1355
    • REESE D, FROHLICH M, BOOK R: A Phase II trial of humanized monoclonal anti-vascular endothelial growth factor antibody in hormone refractory prostate cancer. Proc. Am. Soc. Clin. Oncol. (1999) 18. Abstract 1355, 351a.
    • (1999) Proc. Am. Soc. Clin. Oncol. , vol.18
    • Reese, D.1    Frohlich, M.2    Book, R.3
  • 141
    • 0003037707 scopus 로고    scopus 로고
    • A randomized Phase II trial comparing rhuMabVEGF (recombinant humanized monoclonal antibody to vascular endothelial growth factor) plus 5-fluorouracil/leucovorin (FU/LV) to FU/LV alone in patients with metastatic colorectal cancer
    • Abstract 939
    • BERGSLAND E, HURWITZ H, FAHRENBACHER L: A randomized Phase II trial comparing rhuMabVEGF (recombinant humanized monoclonal antibody to vascular endothelial growth factor) plus 5-fluorouracil/leucovorin (FU/LV) to FU/LV alone in patients with metastatic colorectal cancer. Proc. Am. Soc. Clin. Oncol. (2000) 19. Abstract 939, 242a.
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19
    • Bergsland, E.1    Hurwitz, H.2    Fahrenbacher, L.3
  • 142
    • 0001674315 scopus 로고    scopus 로고
    • A randomized double-blind placebo-controlled trial of bevacizumab (anti-VEGF antibody) demonstrating a prolongation in time to progression in patients with metastatic renal cancer
    • Abstract 15
    • YANG J, HAWORTH L, STEINBERG SM, ROSENBERG SA, NOVOTNY W: A randomized double-blind placebo-controlled trial of bevacizumab (anti-VEGF antibody) demonstrating a prolongation in time to progression in patients with metastatic renal cancer. Proc. Am. Soc. Clin. Oncol. (2002) 21. Abstract 15, 5a.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Yang, J.1    Haworth, L.2    Steinberg, S.M.3    Rosenberg, S.A.4    Novotny, W.5
  • 143
    • 4243326221 scopus 로고    scopus 로고
    • Biomarker analysis of patients samples from a Phase I clinical trial using the angiogenesis inhibitor, SU-6668, for treatment of advanced solid tumors
    • Abstract 336
    • MORIMOTO K, WEST HA, YUEN WR, MATHEWS C, BELLO G: Biomarker analysis of patients samples from a Phase I clinical trial using the angiogenesis inhibitor, SU-6668, for treatment of advanced solid tumors. Proc. Am. Soc. Clin. Oncol. (2002) 21. Abstract 336, 85a.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Morimoto, K.1    West, H.A.2    Yuen, W.R.3    Mathews, C.4    Bello, G.5
  • 144
    • 25944451750 scopus 로고    scopus 로고
    • Pharmacology and toxicology of an antiangiogenic ribozyme
    • IBC 5th Annual Conference: Angiogenesis: novel therapeutic development, Boston. March
    • SANDBERG JA: Pharmacology and toxicology of an antiangiogenic ribozyme. IBC 5th Annual Conference: Angiogenesis: novel therapeutic development, Boston. March 1999.
    • (1999)
    • Sandberg, J.A.1
  • 145
    • 0030482306 scopus 로고    scopus 로고
    • Phase I trial of recombinant platelet factor 4 (rPF4) in patients with advanced colorectal carcinoma
    • BELMAN N, BONNEM EM, HARVEY AH, LIPTON A: Phase I trial of recombinant platelet factor 4 (rPF4) in patients with advanced colorectal carcinoma. Invest. New Drugs (1996) 14:387-389.
    • (1996) Invest. New Drugs , vol.14 , pp. 387-389
    • Belman, N.1    Bonnem, E.M.2    Harvey, A.H.3    Lipton, A.4
  • 146
    • 0001100603 scopus 로고    scopus 로고
    • A Phase I dose escalating study of the angiogenesis inhibitor thrombospondin-mimetis (ABT-510) in patients with advanced cancer
    • DE VOS FYFL, HOEKSTRA R, GIETEMA JA et al.: A Phase I dose escalating study of the angiogenesis inhibitor thrombospondin-mimetis (ABT-510) in patients with advanced cancer. Proc. Am. Soc. Clin. Oncol. (2002) 21:82a.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Devos, F.Y.F.L.1    Hoekstra, R.2    Gietema, J.A.3
  • 148
    • 0037051697 scopus 로고    scopus 로고
    • α v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin
    • TAGA T, SUZUKI A, GONZALEZ-GOMEZ I et al.: α v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. Int. J. Cancer (2002) 98:690-697.
    • (2002) Int. J. Cancer , vol.98 , pp. 690-697
    • Taga, T.1    Suzuki, A.2    Gonzalez-Gomez, I.3
  • 149
    • 0036282502 scopus 로고    scopus 로고
    • Inhibition of angiogenesis: Treatment options for patients with metastatic prostate cancer
    • FIGG WD, KRUGER EA, PRICE DK, KIM S, DAHUT WD: Inhibition of angiogenesis: treatment options for patients with metastatic prostate cancer. Invest. New Drugs (2002) 20:183-194.
    • (2002) Invest. New Drugs , vol.20 , pp. 183-194
    • Figg, W.D.1    Kruger, E.A.2    Price, D.K.3    Kim, S.4    Dahut, W.D.5
  • 150
    • 0033942084 scopus 로고    scopus 로고
    • Phase II evaluation of thalidomide in patients with metastatic breast cancer
    • BAIDAS SM, WINER EP, FLEMING GF et al.: Phase II evaluation of thalidomide in patients with metastatic breast cancer. J. Clin. Oncol. (2000) 18:2710-2717.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 2710-2717
    • Baidas, S.M.1    Winer, E.P.2    Fleming, G.F.3
  • 151
    • 0035671824 scopus 로고    scopus 로고
    • A Phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers
    • BHARGAVA P, MARSHALL JL, DAHUT W et al.: A Phase I and pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin. Cancer Res. (2001) 7:3912-3919.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 3912-3919
    • Bhargava, P.1    Marshall, J.L.L.2    Dahut, W.3
  • 152
    • 0036545491 scopus 로고    scopus 로고
    • Celecoxib with chemotherapy in colorectal cancer
    • BLANKE CD: Celecoxib with chemotherapy in colorectal cancer. Oncology (Huntingt.) (2002) 16:17-21.
    • (2002) Oncology (Huntingt.) , vol.16 , pp. 17-21
    • Blanke, C.D.1
  • 153
    • 0036269257 scopus 로고    scopus 로고
    • Therapeutic options in the management of renal cell carcinoma
    • GLASPY JA: Therapeutic options in the management of renal cell carcinoma. Semin. Oncol. (2002) 29:41-46.
    • (2002) Semin. Oncol. , vol.29 , pp. 41-46
    • Glaspy, J.A.1
  • 155
    • 0036162966 scopus 로고    scopus 로고
    • IL-12-induced production of IL-10 and interferon-γ by mononuclear cells in lung cancer-associated malignant pleural effusions
    • TAKEUCHI E, YANAGAWA H, SUZUKI Y et al.: IL-12-induced production of IL-10 and interferon-γ by mononuclear cells in lung cancer-associated malignant pleural effusions. Lung Cancer (2002) 35:171-177.
    • (2002) Lung Cancer , vol.35 , pp. 171-177
    • Takeuchi, E.1    Yanagawa, H.2    Suzuki, Y.3
  • 156
    • 0032445492 scopus 로고    scopus 로고
    • Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth
    • PIKE SE, YAO L, JONES KD et al.: Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth. J. Exp. Med. (1998) 188:2349-2356.
    • (1998) J. Exp. Med. , vol.188 , pp. 2349-2356
    • Pike, S.E.1    Yao, L.2    Jones, K.D.3
  • 157
    • 0033599308 scopus 로고    scopus 로고
    • Antiangiogenic activity of restin, NC10 domain of human collagen XV: Comparison to endostatin
    • RAMCHANDRAN R, DHANABAL M, VOLK R et al.: Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin. Biochem. Biophys. Res. Commun. (1999) 255:735-739.
    • (1999) Biochem. Biophys. Res. Commun. , vol.255 , pp. 735-739
    • Ramchandran, R.1    Dhanabal, M.2    Volk, R.3
  • 158
    • 0034661728 scopus 로고    scopus 로고
    • Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC
    • VAJKOCZY P, MENGER MD, GOLDBRUNNER R et al.: Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC. Int. J. Cancer (2000) 87:261-268.
    • (2000) Int. J. Cancer , vol.87 , pp. 261-268
    • Vajkoczy, P.1    Menger, M.D.2    Goldbrunner, R.3
  • 159
    • 0031849452 scopus 로고    scopus 로고
    • Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells
    • SHIMO T, NAKANISHI T, KIMURA Y et al.: Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells. J. Biochem. (Tokyo) (1998) 124:130-140.
    • (1998) J. Biochem. (Tokyo) , vol.124 , pp. 130-140
    • Shimo, T.1    Nakanishi, T.2    Kimura, Y.3
  • 160
    • 0027097806 scopus 로고
    • Interleukin-8 as a macrophage-derived mediator of angiogenesis
    • KOCH AE, POLVERINI PJ, KUNKEL SL et al.: Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science (1992) 258:1798-1801.
    • (1992) Science , vol.258 , pp. 1798-1801
    • Koch, A.E.1    Polverini, P.J.2    Kunkel, S.L.3
  • 161
    • 0035214416 scopus 로고    scopus 로고
    • Metronomic scheduling: The future of chemotherapy?
    • GASPARINI G: Metronomic scheduling: the future of chemotherapy? Lancet Oncol. (2001) 2:733-740.
    • (2001) Lancet Oncol. , vol.2 , pp. 733-740
    • Gasparini, G.1
  • 162
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic: Scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • BROWDER T, BUTTERFIELD CE, KRALING BM et al.: Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res. (2000) 60:1878-1886.
    • (2000) Cancer Res. , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3
  • 163
    • 0036570041 scopus 로고    scopus 로고
    • Phase II trial of weekly single-agent paclitaxel in platinum/paclitaxel-refractory ovarian cancer
    • MARKMAN M, HALL J, SPITZ D et al.: Phase II trial of weekly single-agent paclitaxel in platinum/paclitaxel-refractory ovarian cancer. J. Clin. Oncol. (2002) 20:2365-2369.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2365-2369
    • Markman, M.1    Hall, J.2    Spitz, D.3
  • 164
    • 0036256785 scopus 로고    scopus 로고
    • Concomitant radiotherapy and metronomic temozolomide in pediatric high-risk brain tumors
    • STERBA J, PAVELKA Z, SLAMPA P: Concomitant radiotherapy and metronomic temozolomide in pediatric high-risk brain tumors. Neoplasma (2002) 49:117-120.
    • (2002) Neoplasma , vol.49 , pp. 117-120
    • Sterba, J.1    Pavelka, Z.2    Slampa, P.3
  • 165
    • 0033916672 scopus 로고    scopus 로고
    • Activity of thalidomide in AIDS-related Kaposi's sarcoma
    • LITTLE RF, WYVILL KM, PLUDA JM et al.: Activity of thalidomide in AIDS-related Kaposi's sarcoma. J. Clin. Oncol. (2000) 18:2593-2602.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 2593-2602
    • Little, R.F.1    Wyvill, K.M.2    Pluda, J.M.3
  • 167
    • 0033853522 scopus 로고    scopus 로고
    • TNP-470 and recombinant human interferon-α2a inhibit angiogenesis synergistically
    • MINISCHETTI M, VACCA A, RIBATTI D et al.: TNP-470 and recombinant human interferon-α2a inhibit angiogenesis synergistically. Br. J. Haematol. (2000) 109:829-837.
    • (2000) Br. J. Haematol. , vol.109 , pp. 829-837
    • Minischetti, M.1    Vacca, A.2    Ribatti, D.3
  • 168
    • 0034070283 scopus 로고    scopus 로고
    • Potentiated antitumor effects of interleukin 12 and matrix metalloproteinase inhibitor batimastat against B16F10 melanoma in mice
    • DABROWSKA A, GIERMASZ A, MARCZAK M, GOLAB J, JAKOBISIAK M: Potentiated antitumor effects of interleukin 12 and matrix metalloproteinase inhibitor batimastat against B16F10 melanoma in mice. Anticancer Res. (2000) 20:391-394.
    • (2000) Anticancer Res. , vol.20 , pp. 391-394
    • Dabrowska, A.1    Giermasz, A.2    Marczak, M.3    Golab, J.4    Jakobisiak, M.5
  • 169
    • 0034234623 scopus 로고    scopus 로고
    • Human endothelial cells express CCR2 and respond to MCP-1: Direct role of MCP-1 in angiogenesis and tumor progression
    • SALCEDO R, PONCE ML, YOUNG HA et al.: Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. Blood (2000) 96:34-40.
    • (2000) Blood , vol.96 , pp. 34-40
    • Salcedo, R.1    Ponce, M.L.2    Young, H.A.3
  • 170
    • 0035692285 scopus 로고    scopus 로고
    • Possible mechanisms of acquired resistance to anti-angiogenic drugs: Implications for the use of combination therapy approaches
    • KERBEL RS, YU J, TRAN J et al.: Possible mechanisms of acquired resistance to anti-angiogenic drugs: implications for the use of combination therapy approaches. Cancer Metastasis Rev. (2001) 20:79-86.
    • (2001) Cancer Metastasis Rev. , vol.20 , pp. 79-86
    • Kerbel, R.S.1    Yu, J.2    Tran, J.3
  • 171
    • 0033617532 scopus 로고    scopus 로고
    • Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
    • BERGERS G, JAVAHERIAN K, LO KM, FOLKMAN J, HANAHAN D: Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science (1999) 284:808-812.
    • (1999) Science , vol.284 , pp. 808-812
    • Bergers, G.1    Javaherian, K.2    Lo, K.M.3    Folkman, J.4    Hanahan, D.5
  • 172
    • 0036499078 scopus 로고    scopus 로고
    • Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme
    • GROVES MD, PUDUVALLI VK, HESS KR et al.: Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme. J. Clin. Oncol. (2002) 20:1383-1388.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1383-1388
    • Groves, M.D.1    Puduvalli, V.K.2    Hess, K.R.3
  • 173
    • 0032887340 scopus 로고    scopus 로고
    • Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry
    • MANIOTIS AJ, FOLBERG R, HESS A et al.: Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am. J. Pathol. (1999) 155:739-752.
    • (1999) Am. J. Pathol. , vol.155 , pp. 739-752
    • Maniotis, A.J.1    Folberg, R.2    Hess, A.3
  • 175
    • 0042366200 scopus 로고    scopus 로고
    • Microarray study of vasculogenic mimicry in bi-directional differentiation malignant tumor
    • HAO X, SUN B, ZHANG S, ZHAO X: Microarray study of vasculogenic mimicry in bi-directional differentiation malignant tumor. Zhonghua Yi Xue Za Zhi (2002) 82:1298-1302.
    • (2002) Zhonghua Yi Xue Za Zhi , vol.82 , pp. 1298-1302
    • Hao, X.1    Sun, B.2    Zhang, S.3    Zhao, X.4
  • 176
    • 0033903189 scopus 로고    scopus 로고
    • Vasculogenic mimicry in tumors. Fact or artifact?
    • FAUSTO N: Vasculogenic mimicry in tumors. Fact or artifact? Am. J. Pathol. (2000) 156:359.
    • (2000) Am. J. Pathol. , vol.156 , pp. 359
    • Fausto, N.1
  • 177
    • 0035122537 scopus 로고    scopus 로고
    • Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
    • SKOBE M, HAWIGHORST T, JACKSON DG et al.: Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat. Med. (2001) 7:192-198.
    • (2001) Nat. Med. , vol.7 , pp. 192-198
    • Skobe, M.1    Hawighorst, T.2    Jackson, D.G.3
  • 178
    • 0035150823 scopus 로고    scopus 로고
    • Lymphangiogenesis in malignant tumours: Does it occur?
    • CLARIJS R, RUITER DJ, DE WAAL RM: Lymphangiogenesis in malignant tumours: Does it occur? J. Pathol. (2001) 193:143-146.
    • (2001) J. Pathol. , vol.193 , pp. 143-146
    • Clarijs, R.1    Ruiter, D.J.2    De Waal, R.M.3
  • 179
    • 0035266283 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
    • KARPANEN T, EGEBLAD M, KARKKAINEN MJ et al.: Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res. (2001) 61:1786-1790.
    • (2001) Cancer Res. , vol.61 , pp. 1786-1790
    • Karpanen, T.1    Egeblad, M.2    Karkkainen, M.J.3
  • 180
    • 0036959906 scopus 로고    scopus 로고
    • Lymphatic vessel activation in cancer
    • CASSELLA M, SKOBE M: Lymphatic vessel activation in cancer. Ann. NY Acad. Sci. (2002) 979:120-130.
    • (2002) Ann. NY Acad. Sci. , vol.979 , pp. 120-130
    • Cassella, M.1    Skobe, M.2
  • 181
    • 12244289602 scopus 로고    scopus 로고
    • A paradigm for therapy-induced microenvironmental changes in solid tumors leading to drug resistance
    • YU JL, COOMBER BL, KERBEL RS: A paradigm for therapy-induced microenvironmental changes in solid tumors leading to drug resistance. Differentiation (2002) 70:599-609.
    • (2002) Differentiation , vol.70 , pp. 599-609
    • Yu, J.L.1    Coomber, B.L.2    Kerbel, R.S.3
  • 182
    • 0037154738 scopus 로고    scopus 로고
    • Effect of p53 status on tumor response to antiangiogenic therapy
    • YU JL, RAK JW, COOMBER BL, HICKLIN DJ, KERBEL RS: Effect of p53 status on tumor response to antiangiogenic therapy. Science (2002) 295:1526-1528.
    • (2002) Science , vol.295 , pp. 1526-1528
    • Yu, J.L.1    Rak, J.W.2    Coomber, B.L.3    Hicklin, D.J.4    Kerbel, R.S.5
  • 183
    • 0036932906 scopus 로고    scopus 로고
    • Endocrine gland vascular endothelial growth factor (EG-VEGF) and the hypothesis of tissue-specific regulation of angiogenesis
    • FERRARA N, LECOUTER J, LIN R: Endocrine gland vascular endothelial growth factor (EG-VEGF) and the hypothesis of tissue-specific regulation of angiogenesis. Endocr. Res. (2002) 28:763-764.
    • (2002) Endocr. Res. , vol.28 , pp. 763-764
    • Ferrara, N.1    Lecouter, J.2    Lin, R.3
  • 184
    • 0036732411 scopus 로고    scopus 로고
    • Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis
    • LECOUTER J, LIN R, FERRARA N: Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis. Nat. Med. (2002) 8:913-917.
    • (2002) Nat. Med. , vol.8 , pp. 913-917
    • Lecouter, J.1    Lin, R.2    Ferrara, N.3
  • 185
    • 17444376781 scopus 로고    scopus 로고
    • Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin
    • GORSKI DH, MAUCERI HJ, SALLOUM RM et al.: Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin. Cancer Res. (1998) 58:5686-5689.
    • (1998) Cancer Res. , vol.58 , pp. 5686-5689
    • Gorski, D.H.1    Mauceri, H.J.2    Salloum, R.M.3
  • 186
    • 18244419396 scopus 로고    scopus 로고
    • Combined effects of angiostatin and ionizing radiation in antitumour therapy
    • MAUCERI HJ, HANNA NN, BECKETT MA et al.: Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature (1998) 394:287-291.
    • (1998) Nature , vol.394 , pp. 287-291
    • Mauceri, H.J.1    Hanna, N.N.2    Beckett, M.A.3
  • 187
    • 0343953078 scopus 로고    scopus 로고
    • Combination of angiogenesis inhibitor TNP-470 with cytotoxic drugs in experimental therapy of nasopharyngeal carcinoma
    • QIAN CN, MIN HQ, LIN HL, HONG MH: Combination of angiogenesis inhibitor TNP-470 with cytotoxic drugs in experimental therapy of nasopharyngeal carcinoma. Ann. Otol. Rhinol. Laryngol. (2000) 109:641-645.
    • (2000) Ann. Otol. Rhinol. Laryngol. , vol.109 , pp. 641-645
    • Qian, C.N.1    Min, H.Q.2    Lin, H.L.3    Hong, M.H.4
  • 188
    • 0028305809 scopus 로고
    • Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents
    • TEICHER BA, HOLDEN SA, ARA G et al.: Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents. Int. J. Cancer. (1994) 57:920-925.
    • (1994) Int. J. Cancer , vol.57 , pp. 920-925
    • Teicher, B.A.1    Holden, S.A.2    Ara, G.3
  • 189
    • 0035576325 scopus 로고    scopus 로고
    • Vessels of death or life
    • JAIN RK, CARMELIET PF: Vessels of death or life. Sci. Am. (2001) 285:38-45.
    • (2001) Sci. Am. , vol.285 , pp. 38-45
    • Jain, R.K.1    Carmeliet, P.F.2
  • 190
    • 0003266302 scopus 로고    scopus 로고
    • Phase III study of the matrix metalloprotease (MMP) inhibitor prinomastat (P) in combination with gemcitabine (G) and cisplatin (C) in non-small cell lung cancer (NSCLC)
    • Abstract 1183, 296a
    • BISSETT D, VON PAWEL J, MERCIER R et al.: Phase III study of the matrix metalloprotease (MMP) inhibitor prinomastat (P) in combination with gemcitabine (G) and cisplatin (C) in non-small cell lung cancer (NSCLC). Proc. Am. Soc. Clin. Oncol. (2002) 21. Abstract 1183, 296a.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Bissett, D.1    Von Pawel, J.2    Mercier, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.