Effects of microenvironmental extracellular pH and extracellular matrix proteins on angiostatin's activity and on intracellular pH

General Pharmacology: Vascular System

Volumn 35, Issue 5, 2000, Pages 277-285

  Wahl, Miriam L ^a   Grant, Derrick S ^b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Angiogenesis; Angiostatin; Extracellular acidification; Fluorescent indicator dye; Intracellular pH regulation

Indexed keywords

ANGIOGENESIS INHIBITOR; ANGIOSTATIN; ARGINYLGLYCYLASPARTIC ACID; FIBRONECTIN; MATRIGEL; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; RECEPTOR SUBUNIT;

ANGIOGENESIS; CELL CULTURE; CELL DEATH; CELL MIGRATION; CELL PH; CELL SURFACE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SPECIFICITY; ENDOTHELIUM CELL; ENZYME ASSAY; HISTOCHEMISTRY; HUMAN; HUMAN CELL; INCUBATION TIME; MICROENVIRONMENT; PH; PRIORITY JOURNAL; STAINING; TUMOR;

ANGIOGENESIS INHIBITORS; ANGIOSTATINS; CELL DEATH; CELL MOVEMENT; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX PROTEINS; EXTRACELLULAR SPACE; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR FLUID; PEPTIDE FRAGMENTS; PLASMINOGEN; UMBILICAL VEINS;

EID: 0034581338     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(01)00115-X     Document Type: Conference Paper

References (50)

1. FAK) expression correlates with motility of human melanoma cell lines
2. Assays for angiogenesis: A review
3. Modifications of tumor histology by point mutations in the v-fps oncogene: Possible role of extracellular matrix
4. The effect of extracellular pH on angiogenesis in vitro
5. The biosynthesis of extracellular-matrix components by bovine retinal endothelial cells displaying distinctive morphological phenotypes
6. Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD
7. + exchangers
8. Acidosis inhibits endothelial cell apoptosis and function and induces basic fibroblast growth factor and vascular endothelial growth factor expression
9. Apoptotic cell nuclei favour aggregation and fluorescence quenching of DNA dyes
10. Tumor angiogenesis
11. What is the evidence that tumors are angiogenesis dependent?
12. Inhibition of angiogenesis
13. Angiogenic factors
14. Angiogenesis
15. Control of adhesion-dependent cell survival by focal adhesion kinase
16. Quantitative analysis of alpha-fetoprotein mRNA in circulating peripheral blood of patients with hepatocellular and α-fetoprotein-producing gastric carcinomas
17. Regulation of pH in murine tumor and muscle
18. Angiostatin's partners
19. The role of basement membrane in vascular development
20. Matrigel induces thymosin β4 gene in differentiating endothelial cells
21. Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases and chronic inflammation
22. + antiport: Assessment of effect on intracellular pH
23. 2+ indicators with greatly improved fluorescence properties
24. The proton-linked monocarboxylate transporter (MCT) family: Structure, function, and regulation
25. Inhibitors of basement membrane collagen synthesis prevent endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo
26. Multiple forms of angiostatin induce apoptosis in endothelial cells
27. Relation of neovascularisation to metastasis of non-small-cell lung cancer
28. Angiostatin binds ATP synthase on the surface of human endothelial cells
29. Endothelial cell surface F1 - Fo ATP synthase is active in ATP synthesis and is inhibited by angiostatin
30. Recombinant human angiostatin protein inhibits both migration and tube formation of human endothelial cells
31. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
32. Dependence of proton generation on aerobic or anaerobic metabolism and implications for tumor pH
33. +]
34. Temporal association between alterations in proton extrusion and low pH adaptation
35. Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex
36. Reciprocal paracrine interactions between tumour cells and endothelial cells 'angiogenesis progression' hypothesis
37. Signaling by integrins: Implications for tumorigenesis
38. + antiporter by clustering and immobilizing integrin α v β 1, independent of cell shape
39. Acid pH in tumors and its potential for therapeutic exploitation
40. Thermotolerance and intracellular pH in two Chinese hamster cell lines adapted to growth at low pH
41. Effects of 42°C hyperthermia on intracellular pH in ovarian carcinoma cells during acute acidification or chronic exposure to low extracellular pH
42. Intracellular pH regulation in a nonmalignant and a derived malignant human breast cell line
43. Low dose angiostatin induces intracellular acidosis and anoikis cell death in endothelial cells at tumor-like low pH
44. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma
45. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma
46. Factors affecting topotecan-induced programmed cell death, adhesion protects cells from apoptosis and impairs cleavage of poly(ADP-ribose)polymerase
47. The relevance of tumor pH in the treatment of malignant disease
48. Suppression of tumor growth with recombinant murine angiostatin
49. The chronic administration of drugs that inhibit the regulation of intracellular pH: In vitro and anti-tumour effects