A role for extracellular Na+ in the channel gating of native and recombinant kainate receptors

Journal of Neuroscience

Volumn 23, Issue 25, 2003, Pages 8641-8648

  Paternain, Ana V ^a   Cohen, Adir ^b   Stern Bach, Yael ^b   Lerma, Juan ^a  

^a INSTITUTO CAJAL   (Spain)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Allosteric modulation; AMPA; Channel gating; Chimeras; GluR3; GluR6; Glutamate; KA2; Kainate; Receptors; Structure function

Indexed keywords

AMPA RECEPTOR; CESIUM ION; CONCANAVALIN A; GLUTAMIC ACID; IONOTROPIC RECEPTOR; KAINIC ACID RECEPTOR; LITHIUM ION; POTASSIUM ION; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR; SODIUM ION;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CHANNEL GATING; CHIMERA; CONTROLLED STUDY; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; MEMBRANE CURRENT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; XENOPUS;

EID: 0042199046     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-25-08641.2003     Document Type: Article

References (38)

1. Armstrong CM, Lopez-Barneo J (1987) External calcium ions are required for potassium channel gating in squid neurons. Science 236:712-714.
2. Armstrong N, Gouaux E (2000) Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron 28:165-181.
3. Armstrong N, Sun Y, Chen GQ, Gouaux E (1998) Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature 395:913-917.
4. Ayalon G, Stern-Bach Y (2001) Functional assembly of AMPA and kainate receptors is mediated by several discrete protein-protein interactions. Neuron 31:103-113.
5. Bowie D (2002) External anions and cations distinguish between AMPA and kainate receptor gating mechanisms. J Physiol (Lond) 539:725-733.
6. Bowie D, Lange GD (2002) Functional stoichiometry of glutamate receptor desensitization. J Neurosci 22:3392-3403.
7. Burnashev N, Villarroel A, Sakmann B (1996) Dimensions and ion selectivity of recombinant AMPA and kainate receptor channels and their dependence on Q/R site residues. J Physiol (Lond) 496:165-173.
8. Dietzel I, Heinemann U (1986) Dynamic variations of the brain cell microenvironment in relation to neuronal hyperactivity. Ann N Y Acad Sci 481:72-86.
9. Dietzel I, Heinemann U, Hofmeier G, Lux HD (1982) Stimulus-induced changes in extracellular Na+ and Cl- concentration in relation to changes in the size of the extracellular space. Exp Brain Res 46:73-84.
10. Dingledine R, Borges K, Bowie D, Traynelis SF (1999) The glutamate receptor ion channels. Pharmacol Rev 51:7-61.
11. Heginbotham L, MacKinnon R (1992) The aromatic binding site for tetraethylammonium ion on potassium channels. Neuron 8:483-491.
12. Herreras O, Somjen GG (1993) Propagation of spreading depression among dendrites and somata of the same cell population. Brain Res 610:276-282.
13. Hille B (1992) Ionic channels of excitable membranes. Sunderland, MA: Sinauer.
14. Kash TL, Jenkins A, Kelley JC, Trudell JR, Harrison NL (2003) Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature 421:272-275.
15. Kushner L, Lerma J, Zukin RS, Bennett MV (1988) Coexpression of N-methyl-D-aspartate and phencyclidine receptors in Xenopus oocytes injected with rat brain mRNA. Proc Natl Acad Sci USA 85:3250-3254.
16. Lerma J (1997) Kainate reveals its targets. Neuron 19:1155-1158.
17. Lerma J (2003) Roles and rules of kainate receptors in synaptic transmission. Nat Rev Neurosci 4:481-495.
18. Lerma J, Paternain AV, Naranjo JR, Mellstrom B (1993) Functional kainate-selective glutamate receptors in cultured hippocampal neurons. Proc Natl Acad Sci USA 90:11688-11692.
19. Lerma J, Paternain AV, Salvador N, Somohano F, Morales M, Casado M (1998) Excitatory amino acid-activated channels. In: Ion channel pharmacology (Soria B, Ceña V, eds), pp 399-421. Oxford: Oxford UP.
20. Maas S, Melcher T, Seeburg PH (1997) Mammalian RNA-dependent deaminases and edited mRNAs. Curr Opin Cell Biol 9:343-349.
21. Madden DR (2002) The structure and function of glutamate receptor ion channels. Nat Rev Neurosci 3:91-101.
22. Marshall J, Molloy R, Moss GW, Howe JR, Hughes TE (1995) The jellyfish green fluorescent protein: a new tool for studying ion channel expression and function. Neuron 14:211-215.
23. Pardo LA, Heinemann SH, Terlau H, Ludewig U, Lorra C, Pongs O, Stuhmer W (1992) Extracellular K+ specifically modulates a rat brain K+ channel. Proc Natl Acad Sci USA 89:2466-2470.
24. Partin KM, Fleck MW, Mayer ML (1996) AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate. J Neurosci 16:6634-6647.
25. Paternain AV, Morales M, Lerma J (1995) Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 14:185-189.
26. Peitsch MC (1996) ProMod and Swiss-Model: internet-based tools for automated comparative protein modeling. Biochem Soc Trans 24:274-279.
27. Ruano D, Lambolez B, Rossier J, Paternain AV, Lerma J (1995) Kainate receptor subunits expressed in single cultured hippocampal neurons: molecular and functional variants by RNA editing. Neuron 14:1009-1017.
28. (2+) depletion. Biophys J 81:1947-1959.
29. 2+ depletion contributes to fast activity-dependent modulation of synaptic transmission in the brain. Neuron 37:287-297.
30. Seeburg PH (2002) A-to-I editing: new and old sites, functions and speculations. Neuron 35:17-20.
31. Somjen GG (2001) Mechanisms of spreading depression and hypoxic spreading depression-like depolarization. Physiol Rev 81:1065-1096.
32. Stern-Bach Y, Bettler B, Hartley M, Sheppard PO, O'Hara PJ, Heinemann SF (1994) Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins. Neuron 13:1345-1357.
33. Sun Y, Olson R, Horning M, Armstrong N, Mayer M, Gouaux E (2002) Mechanism of glutamate receptor desensitization. Nature 417:245-253.
34. Swanson GT, Gereau 4th RW, Green T, Heinemann SF (1997) Identification of amino acid residues that control functional behavior in GluR5 and GluR6 kainate receptors. Neuron 19:913-926.
35. Swanson GT, Green T, Heinemann SF (1998) Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine. Mol Pharmacol 53:942-949.
36. Unwin N, Miyazawa A, Li J, Fujiyoshi Y (2002) Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the α subunits. J Mol Biol 319:1165-1176.
37. Yeh JZ, Armstrong CM (1978) Immobilisation of gating charge by a substance that simulates inactivation. Nature 273:387-389.
38. Zhang Y, Bendahan A, Zarbiv R, Kavanaugh MP, Kanner BI (1998) Molecular determinant of ion selectivity of a (Na+ + K+)-coupled rat brain glutamate transporter. Proc Natl Acad Sci USA 95:751-755.