Kainate receptors exhibit differential sensitivities to (S)-5- Iodowillardiine

Molecular Pharmacology

Volumn 53, Issue 5, 1998, Pages 942-949

  Swanson, Geoffrey T ^a   Green, Tim ^a   Heinemann, Stephen F ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 IODOWILLARDIINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; GLUTAMATE RECEPTOR; KAINIC ACID; KAINIC ACID RECEPTOR; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG; WILLARDIINE; WILLARDIINE DERIVATIVE;

ARTICLE; CELL MEMBRANE POTENTIAL; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; PLANT SEED; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; SPINAL GANGLION; SYNAPTIC TRANSMISSION;

ALANINE; CELL LINE; HUMANS; PYRIMIDINES; RECEPTORS, GLUTAMATE; RECEPTORS, KAINIC ACID; RECOMBINANT PROTEINS;

EID: 0031750767     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Castillo PE, Malenka RC, and Nicoll RA (1997) Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons. Nature (Lond) 388:182-186.
2. Chittajallu R, Vignes M, Dev KK, Barnes JM, Collingridge GL, and Henley JM (1996) Regulation of glutamate release by presynaptic kainate receptors in the hippocampus. Nature (Lond) 379:78-81.
3. Clarke VR, Ballyk BA, Hoo KH, Mandelzys A, Pellizzari A, Bath CP, Thomas J, Sharpe EF, Davies CH, Ornstein PL, Schoepp DD, Kamboj RK, Collingridge GL, Lodge D, and Bleakman D (1997) A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature (Lond) 389:599-603.
4. Heckmann M, Bufler J, Franke C, and Dudel J (1996) Kinetics of homomeric GluR6 glutamate receptor channels. Biophys J 71:1743-50.
5. Huettner JE (1990) Glutamate receptor channels in rat DRG neurons: Activation by kainate and quisqualate and blockade of desensitization by Con A. Neuron 5:255-266.
6. Jane DE, Hoo K, Kamboj R, Deverill M, Bleakman D, and Mandelzys A (1997) Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J Med Chem 40:3645-3650.
7. Mulle C, Sailer A, Pérez-otaño I, Dickinson-Anson H, Castillo PE, Bureau I, Maron C, Gage FH, Mann JR, Behler B, and Heinemann SF (1998) Altered synaptic physiology and reduced kainate susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature (Lond) 392:601-605.
8. Partin KM, Patneau DK, Winters CA, Mayer ML, and Buonanno A (1993) Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron 11:1069-1082.
9. Paternain AV, Morales M, and Lerma J (1995) Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons. Neuron 14:185-189.
10. Patneau DK, Mayer ML, Jane DE, and Watkins JC (1992) Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine. J Neurosci 12:595-606.
11. Rodriguez-Moreno A, Herreras O, and Lerma J (1997) Kainate receptors presynaptically down-regulate GABAergic inhibition in the rat hippocampus. Neuron 19: 893-901.
12. Schiffer HH, Swanson GT, and Heinemann SF (1997) Rat GluR7 and a carboxyterminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate. Neuron 19:1141-1146.
13. Sommer B, Burnashev N, Verdoorn TA, Keinänen K, Sakmann B, and Seeburg PH (1992) A glutamate receptor channel with high affinity for domoate and kainate. EMBO J 11:1651-1656.
14. Swanson GT, Feldmeyer D, Kaneda M, and Cull-Candy SG (1996) Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors. J Physiol 492:129-142.
15. Swanson GT, Gereau RW IV, Green T, and Heinemann SF (1997) Identification of amino acid residues that control functional behavior in GluR5 and GluR6 kainate receptors. Neuron 19:913-926.
16. Traynelis SF and Wahl P (1997) Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin. J Physiol 503:513-531.
17. Vignes M and Collingridge GL (1997) The synaptic activation of kainate receptors. Nature (Lond) 388:179-182.
18. Wilding TJ and Huettner JE (1997) Activation and desensitization of hippocampal kainate receptors. J Neurosci 17:2713-2721.
19. Wong LA, Mayer ML, Jane DE, and Watkins JC (1994) Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons. J Neurosci 14:3881-3897.