In vivo regulation of peripheral-type benzodiazepine receptor and glucocorticoid synthesis by Ginkgo biloba extract EGB 761 and isolated ginkgolides

Endocrinology

Volumn 137, Issue 12, 1996, Pages 5707-5718

  Amri, Hakima ^a   Ogwuegbu, Stephen O ^a   Boujrad, Noureddine ^a   Drieu, Katy ^b   Papadopoulos, Vassilios ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b Institut Henri Beaufour   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4' CHLORODIAZEPAM; ALDOSTERONE; BENZODIAZEPINE RECEPTOR; BILOBALIDE; CORTICOSTERONE; CORTICOTROPIN; CYTOCHROME P450; GINKGO BILOBA EXTRACT; GINKGOLIDE A; GINKGOLIDE B; GLUCOCORTICOID; REGULATOR PROTEIN; TESTOSTERONE;

ADRENAL FUNCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN RELEASE; DOSE RESPONSE; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LIGAND BINDING; MALE; MITOCHONDRION; NEUROPROTECTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STEROIDOGENESIS; STRUCTURE ACTIVITY RELATION;

EID: 0030458395     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.12.8940403     Document Type: Article

References (49)

1. Chrousos GP, Gold PW 1992 The concepts of stress and stress system disorders. JAMA 267:1244-1252
2. Munck A, Naray-Fejes-Toth A 1994 Glucocorticoids and stress: permissive and suppressive actions. Ann NY Acad Sci 746:115-133
3. Sapolsky RM 1994 The physiological relevance of glucocorticoid endangerment of the hippocampus. Ann NY Acad Sci 746:294-307
4. McEwen BS 1994 Corticosteroids and hippocampal plasticity. Ann NY Acad Sci 746:134-144
5. deKloet ER, Azmitia EC, Landfield PW 1994 Brain corticosteroid receptors. Studies on the mechanism, function, and neurotoxicity of corticosteroid action. Ann NY Acad Sci, vol 746
6. Orrell MW, O'Dwyer A-M 1995 Dementia, ageing, and the stress control system. Lancet 345:666-667
7. Kirschbaum C, Wolf OT, May M, Wippich W, Hellhammer DH 1996 Stressand treatment-induced elevations of cortisol levels associated with impaired declarative memory in helthy adults. Life Sci 58:1475-1483
8. Simpson ER, Waterman MR 1983 Regulation by ACTH of steroid hormone biosynthesis in the adrenal cortex. Can J Biochem Cell Biol 61:692-707
9. scc in steroid hormone synthesis. J Steroid Biochem Mol Biol 43:751-767
10. DeFeudis FV 1991 Ginkgo biloba Extract (EGb 761): Pharmacological Activities and Clinical Applications. Elsevier, Paris
11. Christen Y, Courtois Y, Droy-Lefaix MT 1995 Effects of Gingko biloba Extract (EGb 761) on Aging and Age-Related Disorders. Elsevier, Paris
12. Hofferberth B 1994 The efficacy of EGb 761 in patients with senile dementia of the Alzheimer type, a double-blind, placebo-controlled study on different levels of investigation. Hum Psychopharmcol 9:215-222
13. Itil T, Martorano D 1995 Natural substances on psychiatry (Ginkgo biloba in dementia). Psychopharmcol Bull 31:147-158
14. Christen Y, Costendin J, Lacour M 1991 Effects of Gingko biloba Extract (EGb 761) on the Central Nervous System. Elsevier, Paris
15. Porsolt RD, Martin P, Lenegere A, Fromage S, Drieu K 1990 Effects of an extract of Ginkgo biloba (EGb 761) on "learned helplessness" and other models of stress in rodents. Pharmacol Biochem Behav 36:963-971
16. Rapin JR, Lamproglou I, Drieu K, DeFeudis FV 1994 Demonstration of the "anti-stress" activity of an extract of Ginkgo biloba (EGb 761) using a discrimination learning task. Gen Pharmacol 25:1009-1016
17. Papadopoulos V 1993 Peripheral-type benzodiazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocr Rev 14:222-240
18. Papadopoulos V, Brown AS 1995 Role of the peripheral-type benzodiazepine receptor and the polypeptide diazepam binding inhibitor in steroidogenesis. J Steroid Biochem Mol Biol 53:103-110
19. Riond J, Mattei MG, Kaghad M, Dumont X, Guillemot JC, Le Fur G, Caput D, Ferrara P 1991 Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor. Eur J Biochem 195:305-311
20. Oke BO, Suarez-Quian CA, Riond J, Ferrara P, Papadopoulos V 1992 Cell surface localization of the peripheral-type benzodiazepine receptor in adrenal cortex. Mol Cell Endocrinol 87:R1-R6
21. Garnier M, Boujrad N, Oke BO, Brown AS, Riond J, Ferrara P, Shoyab M, Suarez-Quian CA, Papadopoulos V 1993 Diazepam binding inhibitor is a paracrine/autocrine regulator of Leydig cell proliferation and steroidogenesis. Action via peripheral-type benzodiazepine receptor and independent mechanisms. Endocrinology 132:444-458
22. Garnier M, Dimchev A, Boujrad N, Price MJ, Musto NA, Papadopoulos V 1994 In vitro reconstitution of a functional peripheral-type benzodiazepine receptor. Mol Pharmacol 45:201-211
23. Clark BJ, Wells J, King SR, Stocco DM 1994 The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. J Biol Chem 269:28314-28322
24. Babel D, Walter G, Gotz H, Thinnes FP, Jurgens L, Konig U, Hilschmann N 1991 Studies on human porin. VI. Production and characterization of eight monoclonal mouse antibodies against the human VDAC porin 31HL and their application for histopathological studies in human skeletal muscle. Biol Chem Hoppe Seyler 372:1027-1034
25. Chrousos GP, Schulte HM, Oldfield EH, Gold PW, Cutler, Jr, GB, Loriaux DL 1984 The corticotropin-releasing factor stimulation test. N Engl J Med 310:622-626
26. Papadopoulos V, Mukhin AG, Costa E, Krueger KE 1990 The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. J Biol Chem 265:3772-3779
27. Krueger KE, Papadopoulos V 1990 Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells. J Biol Chem 265:15015-15022
28. McNamara BC, Jefcoate CR 1990 Heterogeneous pools of cholesterol side-chain cleavage activity in adrenal mitochondria from ACTH-treated rats: different responses to different reducing precursors. Mol Cell Endocrinol 73:123-134
29. Rainey WE, Bird IM, Sawetawan C, Hanley NA, McCarthy JL, McGee EA, Webster R Mason JI 1993 Regulation of human adrenal carcinoma cell (NCI-H295) production of C19 steroids. J Clin Endocrinol Metab 77:731-737
30. Munson PJ, Rodbard D 1980 LIGAND: a versatile computerized approach for characterization of ligand binding systems. Anal Biochem 107:220-239
31. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
32. Dym M, Lamsam-Casalotti S, Jia M-C, Kleinman HK, Papadopoulos V 1991 Basement membrane increases G-protein levels and FSH responsiveness of Sertoli cell adenylyl cyclase. Endocrinology, 128:1167-1176
33. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein-dye binding. Anal Biochem 72:248-254
34. Gavish M, Katz Y, Bar-Ami S, Weizman R 1992 Biochemical, physiological, and pathological aspects of the peripheral benzodiazepine receptor. J Neurochem 58:1589-1601
35. Rodriguez de Turco EB, Droy-Lefaix MT, Bazan N 1993 EGb 761 inhibits stress-induced polydipsia in rats. Physiol Behav 53:1001-1002
36. Yanagibashi K, Ohno Y, Nakamichi N, Matsui T, Hayashida K, Takamura M, Yamada K, Tou S, Kawamura M 1989 Peripheral-type benzodiazepine receptors are involved in the regulation of cholesterol side chain cleavage in adrenocortical mitochondria. J Biochem 106:1026-1029
37. Amsterdam A, Suh BS 1991 An inducible functional peripheral benzodiazepine receptor in mitochondria of steroidogenic granulosa cells. Endocrinology 128:503-510
38. Sprengel R, Werner P, Seeburg PH, Mukhin AG, Santi MR, Grayson DR, Guidotti A, Krueger KE 1989 Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor. J Biol Chem 264:20415-20421
39. Chang YJ, McCabe RT, Rennert H, Budarf ML, Sayegh R, Emanuel BS, Skolnick P, Srauss JF 1992 The human "peripheral-type" benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA. DNA Cell Biol 11:471-480
40. McEnery MW, Snowman AM, Trifiletti RR, Snyder SH 1992 Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc Natl Acad Sci USA 89:3170-3174
41. Bernassau JM, Reversat JL, Ferrara P, Caput D, Lefur G 1993 A 3D model of the peripheral benzodiazepine receptor and its implication in intra mitochondrial cholesterol transport. J Mol Graphics 11:236-245
42. Holmes PV, Stringer AP, Drugan RC 1992 Impact of psychological dynamics of stress on the peripheral benzodiazepine receptor. Pharmacol Biochem Behav 42:437-444
43. Drugan RC, Holmes PV, Scher DM, Luczak S, Oh H, Ferland RJ 1995 Environmentally induced changes in peripheral benzodiazepine receptors are stressors and tissue specific. Pharmacol Biochem Behav 50:551-562
44. Oberto A, Longone P, Krueger KE 1995 Identification of three transcriptional regulatory elements in the rat mitochondrial benzodiazepine receptor-encoding gene. Gene 167:255-260
45. Besman MJ, Yanagibashi K, Lee TD, Kawamura M, Hall PF, Shively JE 1989 Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor. Proc Natl Acad Sci USA 86:4897-4901
46. Garnier M, Boujrad N, Ogwuegbu SO, Hudson, Jr, JR, Papadopoulos V 1994 The polypeptide diazepam binding inhibitor and a higher affinity peripheral-type benzodiazepine receptor sustain constitutive steroidogenesis in the R2C Leydig tumor cell line. J Biol Chem 269:22105-22112
47. Boujrad N, Hudson JR, Papadopoulos V 1993 Inhibition of hormone-stimulated steroidogenesis in cultured Leydig tumor cells by a cholesterol-linked phosphorothioate oligodeoxynucleotide antisense to diazepam binding inhibitor. Proc Natl Acad Sci USA 90:5728-5731
48. Schultz R, Pelto-Huikko M, Alho H 1992 Expression of diazepam binding inhibitor-like immunoreactivity in rat testis is dependent on pituitary hormones. Endocrinology 130:3200-3206
49. Clark BJ, Soo S-C, Caron KM, Ikeda Y, Parker KL, Stocco DM 1995 Hormonal and developmental regulation of the steroidogenic acute regulatory protein. Mol Endocrinol 9:1346-1355