Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: Towards a pharmacophore model for the nucleotide-binding domain

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 18, 2003, Pages 4113-4120

  Springsteel, Mark F ^a   Galietta, Luis J V ^b   Ma, Tonghui ^c   By, Kolbot ^a   Berger, Gideon O ^a   Yang, Hong ^c   Dicus, Christopher W ^a   Choung, Wonken ^a   Quan, Chao ^a   Shelat, Anang A ^c   Guy, R Kiplin ^c   Verkman, A S ^c   Kurth, Mark J ^a   Nantz, Michael H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b G GASLINI INSTITUTE   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 BROMO 2 (4 PYRIDYL)BENZO[H] 4H CHROMEN 4 ONE; 6 PHENYL 2 (4 PYRIDYL) 4H CHROMEN 4 ONE; APIGENIN; BENZOFLAVONE DERIVATIVE; FLAVONE; GLIBENCLAMIDE; ISOBUTYLMETHYLXANTHINE; MUTANT PROTEIN; NUCLEOTIDE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UCCF 017; UCCF 018; UCCF 029; UCCF 275; UCCF 279; UCCF 281; UCCF 291; UCCF 296; UCCF 320; UCCF 321; UCCF 322; UCCF 323; UCCF 324; UCCF 326; UCCF 327; UCCF 329; UCCF 330; UCCF 332; UCCF 333; UCCF 335; UCCF 336; UCCF 338; UCCF 339; UCCF 340; UCCF 341; UCCF 349; UCCF 350; UCCF 353; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CELL ASSAY; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG BINDING SITE; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; MODEL; NONHUMAN; PHARMACOPHORE; PROTEIN DOMAIN; RAT; STRUCTURE ACTIVITY RELATION; WILD TYPE;

EID: 0041589194     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00435-8     Document Type: Article

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