8-Cyclopentyl-1,3-dipropylxanthine and other xanthines differentially bind to the wild-type and ΔF508 mutant first nucleotide binding fold (NBF- 1) domains of the cystic fibrosis transmembrane conductance regulator

Biochemistry

Volumn 36, Issue 21, 1997, Pages 6455-6461

  Cohen, B E ^a   Lee, G ^a   Jacobson, K A ^a   Kim, Y C ^a   Huang, Z ^b   Sorscher, E J ^b   Pollard, H B ^a,c,d  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^d Building B ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 CYCLOPENTYLTHEOPHYLLINE; ISOBUTYLMETHYLXANTHINE; TRANSMEMBRANE CONDUCTANCE REGULATOR; XANTHINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CHLORIDE TRANSPORT; CYSTIC FIBROSIS; DISSOCIATION CONSTANT; DRUG EFFECT; DRUG PROTEIN BINDING; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE; BINDING, COMPETITIVE; CARRIER PROTEINS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DNA-BINDING PROTEINS; KINETICS; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; XANTHINE; XANTHINES;

EID: 0030943895     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi970150v     Document Type: Article

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