Discovering antisense reagents by hybridization of RNA to oligonucleotide arrays

CIBA Foundation Symposia

Volumn , Issue 209, 1997, Pages 38-46

  Southern, E M ^a   Milner, N ^a   Mir, K U ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; HETERODUPLEX; PHENYLALANINE TRANSFER RNA;

ANIMAL; CHEMISTRY; CONFORMATION; MOLECULAR GENETICS; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDE SEQUENCE; REVIEW;

ANIMALS; BASE SEQUENCE; INDICATORS AND REAGENTS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDES, ANTISENSE; RNA, TRANSFER, PHE;

EID: 0031301021     PISSN: 03005208     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Cazenave C, Loreau N, Toulme J-J, Hélène C 1986 Anti-messenger oligodeoxynucleotides: specific inhibition of rabbit β-globin synthesis in wheat germ extract and Xenopus oocytes. Biochimie 68:1063-1069
2. Milner N, Mir KU, Southern EM 1997 Selecting effective antisense reagents on combinatorial oligonucleotide arrays. Nat Biotechnol 15:537-541
3. Mir KU, Southern EM 1997 RNA structure and the mechanism of duplex formation, submitted
4. Mir KU 1995 Novel approaches for the analysis of nucleic acids. PhD thesis, University of Oxford, UK
5. Monia BP, Johnston JF, Geiger T, Muller M, Fabbro D 1996 Antitumour activity of a phosphorothioate antisense oligodeoxynucleotide targeted against c-raf kinase. Nat Med 2:668-675
6. Offensperger WB, Offensperger S, Walter E, Teubner K, Igloi G, Blum HE, Gerok W 1993 In vivo inhibition of duck hepatitis B virus replication and gene expression by phosphorothioate-modified antisense oligodeoxynucleotides. EMBO J 12:1257-1262
7. Robertus JD, Ladner JE, Finch JT et al 1974 Structure of yeast phenylalanine tRNA at 3 Å resolution. Nature 250:546-551
8. Southern EM, Case-Green SC, Elder JK et al 1994 Arrays of complementary oligonucleotides for analysing the hybridisation behaviour of nucleic acid. Nucleic Acids Res 22:1368-73
9. Stein CA, Cheng Y-C 1993 Antisense oligonucleotides as therapeutic agents - is the bullet really magical? Science 261:1004-1012
10. Suddath FL, Quigley GJ, McPherson A et al 1974 Three-dimensional tertiary structure of yeast phenylalanine transfer RNA. Science 185:435-439
11. Wang L, Elder JK 1997 Program for analysing oligonucleotide arrays, in preparation