Camptothecin conjugated with DNA minor-groove binder netropsin: Enhanced lactone stability, inhibition of human dna topoisomerase I and antiproliferative activity

Anticancer Research

Volumn 23, Issue 3 B, 2003, Pages 2609-2615

  Sukhanova, Alyona ^a   Grokhovsky, Sergei ^b,c   Zhuze, Alexei ^b   Devy, Jerome ^a   Pluot, Michel ^a   Oleinikov, Vladimir ^a,d   Nabiev, Igor ^a  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^b ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^c UNIVERSITY OF OSLO   (Norway)

^d SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

Camptothecin; DNA cleavage; Human DNA topoisomerase 1; Hybrid molecule; Netropsin

Indexed keywords

ANTINEOPLASTIC AGENT; CAMPTOTHECIN CONGOCIDINE CONJUGATE; CAMPTOTHECIN DERIVATIVE; CONGOCIDINE; DNA; DNA TOPOISOMERASE; LACTONE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; COLORECTAL CARCINOMA; CONJUGATE; CONTROLLED STUDY; DNA CLEAVAGE; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENZYME INHIBITION; FLUORESCENCE SPECTROSCOPY; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; HYDROLYSIS; LUNG CARCINOMA; OVARY ADENOCARCINOMA; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; TUMOR CELL LINE;

EID: 0041304906     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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