Differential effects of interleukin-3 and interleukin-1 on the proliferation and interleukin-6 protein secretion of acute myeloid leukemic cells the involvement of ERK, p38 and STAT5

European Cytokine Network

Volumn 10, Issue 4, 1999, Pages 479-490

  Birkenkamp, Kim U ^b   Esselink, Mariet T ^b   Kruijer, Wiebe ^b   Vellenga, Edo ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b NONE

Author keywords

IL 6 protein secretion; Interleukin 1; Interleukin 3; MAP kinases; Proliferation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYTOKINE RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 3; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; STAT5 PROTEIN; SYNAPTOPHYSIN;

ACUTE GRANULOCYTIC LEUKEMIA; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; LEUKEMIA CELL; REVIEW; SIGNAL TRANSDUCTION;

ACUTE DISEASE; CELL DIVISION; DNA; DNA-BINDING PROTEINS; FLAVONOIDS; HUMANS; I-KAPPA B PROTEINS; IMIDAZOLES; INTERLEUKIN-1; INTERLEUKIN-3; INTERLEUKIN-6; LEUKEMIA, MYELOID; MAP KINASE SIGNALING SYSTEM; MILK PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TUMOR CELLS, CULTURED;

EID: 0040204788     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (51)

1. 1. Tuyt L M, Dokter W H, Vellcnga E. 1997. Gene expression, biological effects and clinical aspects of lymphokines. (Review) Crit Rev. Oncol. Hematol. 26: 175.
2. 2. Vellenga E, Ostapovicz D, O'Rourke B, Griffin J D. 1987. Effects of recombinant IL-3, GM-CSF, and G-CSF on proliferation of leukemic clonogenic cells in short-term and long-term cultures. Leukemia 1: 584.
3. 3. Wielenga J J, Vellenga E, Groenewegen A, Sonneveld P, Löwenberg B. 1996. Recombinant human interleukin-3 (rH IL-3) in combination with remission induction chemotherapy in patients with relapsed acute myelogenous leukemia (AML): a phase I/Ii study. Leukemia 10: 43.
4. 4. Kitamura T, Sato N, Arai K, Miyajima A. 1991. Expression cloning of the human IL-3 receptor cDNA reveals a shared ß subunit for human IL-3 and GM-CSF receptors. Cell 66: 1165.
5. 5. Hara T, Miyajima A. 1996. Function and signal transduction mediated by the interleukin-3 receptor system in hematopoiesis. (Review) Stem. Cells 14: 605.
6. 6. Woodcock J M, Bagley C J, Zacharakis B, Lopez A F. 1996. A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3 and IL-5 receptor common ß-chain is necessary and sufficient for high affinity binding and signaling by all three ligands. J. Biol. Chem. 271: 25999.
7. 7. Sato N, Sakamaki K, Terada N, Arai K, Miyajima A. 1993. Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common ß subunit responsible for different signaling. EMBO J. 12: 4181.
8. 8. Sakamaki K, Miyajima I, Kitamura T, Miyajima A. 1992. Critical cytoplasmic domains of the common ß subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J. 11: 3541.
9. 9. Quelle F W, Sato N, Witthuhn B A, Inhorn R C, Eder M, Miyajima A, Griffin J D, Ihle J N. 1994. JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane proximal region. Mol. Cell Biol. 14: 4335.
10. 10. Terada K, Kaziro Y, Satoh T. 1997. Ras-depcndent activation of c-Jun N-terminal kinase/stress-activated protein kinase in response to interleukin-3 stimulation in hematopoietic BaF3 cells. J. Biol. Chem. 272: 4544.
11. 11. Foltz I N, Lee J C, Young P R, Schrader J W. 1997. Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activatcd protein kinase pathway. J. Biol. Chem. 272: 3296.
12. 12. Nagata Y, Moriguchi T, Nishida E, Todokoro K. 1997. Activation of p38 MAP kinase pathway by erythropoietin and interleukin-3. Blood 90: 929.
13. 13. Xia Z, Dickens M, Raingeaud J, Davis R J, Greenberg M E. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326.
14. 14. Kyriakis J M, Banerjee P, Nikolakaki E, Dai T, Rubic E A, Ahmad M F, Avnich J, Woodgett J R. 1994. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369: 156.
15. 15. Raingeaud J, Gupta S, Rogers J S, Dickens M, Han J, Ulevitch R J, Davis R J. 1995. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol Chem. 270: 7420.
16. 16. Greenfeder S A, Nunes P, Kwee L, Labow M, Chizzonite RA, Ju G. 1995. Molecular cloning and characterization of a second subunit of the interleukin-l receptor complex. J. Biol. Chem. 270: 13757.
17. 17. Guan Z, Tetsuka T, Baier L D, Morrison A R. 1996. Interleukin-Iß activates c-jun NH2-terminal kinase subgroup of mitogen-activated protein kinases in mesanglial cells. Am. J. Physiol. 270: 634.
18. 18. Huwiler A, Pfeilschifter J. 1994. Interleukin-l stimulates De novo synthesis of mitogen-activated protein kinase in glomerular mesanglial cells. FEBS Lett. 350: 135.
19. 19. Bird T A, Schule H D, Delaney P, de Roos P, Sleath P, Dower S K, Virca G D. 1994. The interleukin-l-stimulated protein kinase that phosphorylates heat shock protein hsp27 is activated by MAP kinase. FEBS Lett. 338: 31.
20. 20. Cao Z, Henzel W J, Gao X. 1996. IRAK: a kinase associated with the interleukin-l receptor. Science 271: 1128.
21. 21. Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel D V. 1996. TRAF6 is a signal transducer for interleukin-1. Nature 383: 443.
22. 22. Malinin N L, Boldin M P, Kovalenko A V, Wallach D. 1997. MAP3K-related kinase involved in NFκB induction by TNF, CD95 and IL-1. Nature 385: 540.
23. 23. Baeuerle P A, Baltimore D. 1996. NFκB: ten years after. Cell 87: 13.
24. 24. Libermann T A, Baltimore D. 1990. Activation of interleukin-6 gene expression through the NFκB transcription factor. Mol Cell Biol. 10: 2327.
25. 25. Hiscott J, Marois J, Garoufalis J, D'Addario M, Roulston A, Kwan I, Pepin N, Lacoste J, Nguyen H, Bensi G, Fenton M. 1993. Characterization of a functional NFκB site in the human interleukin-l ß promoter: evidence for a positive autoregulatory loop. Mol. Cell Biol. 13: 6231.
26. 26. Nishizawa M, Nagata S. 1990. Regulatory elements responsible for inducible expression of the granulocyte colony-stimulating factor gene in macrophages. Mol. Cell Biol. 10: 2002.
27. 27. Collart M, Baeuerle P A, Vassalli P. 1990. Regulation of tumor necrosis factor-α transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NFκB. Mol. Cell Biol. 10: 1498.
28. 28. Alessi D R, Cuenda A, Cohen P, Dudley D T, Saltiel A R. 1995. PD 98059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270: 27489.
29. 29. Cuenda A, Rouse J, Doza Y N, Meier R, Cohen P, Gallagher T F, Young P R, Lee J C. 1995. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364: 229.
30. 30. Schulze-Osthoff K, Ferrari D, Riehemann K, Wesselborg S. 1997. Regulation of NFκB activation by MAP kinase cascades. (Review) Immunobiology 198: 35.
31. 31. Karin M. 1998. Mitogen-activated protein kinase cascades as regulators of stress responses. (Review) Ann. NY. Acad. Sci. 851: 139.
32. 32. Mui A L, Wakao H, Kinoshita T, Kitamura T, Miyajima A. 1996. Suppression of interleukin-3-induced gene expression by a C-terminal truncated STAT5: role of STAT5 in proliferation. EMBO J. 15: 2425.
33. 33. French-American-British (FAB) Cooperative Group. 1985. Proposed revised criteria for the classification of acute myeloid leukemia. Ann. Intern. Med. 103: 620.
34. 34. Kitamura T, Tange T, Terasawa T, Chiba S, Kuwaki T, Miyagawa K, Piao Y F, Miyazono K, Urabe A, Takaku F. 1989. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3 or erythropoietin. J. Cell Phyxiol. 140: 323.
35. 35. Avanzi G C, Porcu P, Brizzi M F, Ghigo D, Bosia A, Pego-raro L. 1991. Interleukin 3-dependent proliferation of the human Mo-7 cell line is supported by discrete activation of late Gl genes. Cancer Res. 51: 1741.
36. 36. Helle M, Boeije L, de Groot E, de Vos A, Aarden L. 1991. Sensitive ELISA for IL-6. Detection of IL-6 in biological fluids and sera. J. Inmnmol. Meth. 138: 47.
37. 37. Schreiber E, Matthias P, Müller M M, Schaffner W. 1989. Rapid detection of octamer binding proteins with "mini extracts", prepared from a small number of cells. Nucleic. Acids. Res. 17: 6419.
38. 38. Dokter W H, Tuyt L M L, Sierdsema S J, Esselink M T, Vellenga E. 1995. The spontaneous expression of interleukin-1 beta and interleukin-6 is associated with spontaneous expression of AP-1 and NFkappa B transcription factor in acute myeloblastic leukemia cells. Leukemia 9: 425.
39. 39. Beadling C, Ng J, Babbage J W, Cantrell D A. 1996. Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/thrconine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway. EMBO J. 15: 1902.
40. 40. Raingeaud J, Whitmarsh A J, Barrett T, Dérijard B, Davis R J. 1996. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell Biol. 16: 1247.
41. 41. Wen Z, Zhong Z, Darnell J E Jr. 1995. Maximal activation of transcription by STAT1 and STAT3 requires both tyrosine and serine phosphorylation. Cell 82: 241.
42. 42. Verma T M, Stevenson J. 1997. IκB kinase: beginning, not the end. (Review) Proc. Natl. Acad. Sci. USA 94: 11 758.
43. 43. Crawley J B, Rawlinson L, Lali F V, Page T H, Saklatvala J, Foxwell B M. 1997. T cell proliferation in response to interleu-kins-2 and 7 requires p38MAP kinase activation. J. Biol. Chem. 272: 15023.
44. 44. Schuringa J J, Jonk L J C, Dokter W H A, Vellenga E, Kruijer W. IL-6 induced STAT3 transactivation involves Vav, Rac-1 and SEK-1 but not JNK-1 as signal transduction components. (Submitted).
45. 45. Feldman G M, Rosenthal L A, Liu X, Hayes M P, Wynshaw-Boris A, Leonard W J, Hennighausen L, Finbloom D S. 1997. STAT5A-dcficient mice demonstrate a defect in granulocytemacrophagc colony-stimulating factor-induced proliferation and gene expression. Blood 90: 1768.
46. 46. Gringhuis S I, Leij De L F M H, Vellenga E. Serine phosphorylation of STAT5 in response to interleukin-7 and T cell receptor activation is mediated by the mitogen-activated kinase p38/Mpk2 in human T lymphocytes. (Submitted).
47. 47. Rothwarf D M, Zandi E, Natoli G, Karin M. 1998. IKK-y is an essential regulatory subunit of the IκB kinase complex. Nature 395: 297.
48. 48. Zhang M Y, Sun S C, Bell L, Mille B A. 1998. NFκB Transcription Factors are involved in normal Erythropoiesis. Blood 91: 4136.
49. 49. Scheid M P, Duronio V. 1998. Dissociation of cytokineinduced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation. Proc. Natl. Acad. Sci. USA 95: 7439.
50. 50. Vanden Berghe W, Plaisance S, Boone E, De Bosscher K, Schmitz M L, Fiers W, Haegeman G. 1998. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-κB p65 transactivation mediated by tumor necrosis factor. J. Biol. Chem. 273: 3285.
51. 51. Tuyt L M, Dokte W H, Birkenkamp K U, Koopmans S B, Lummen C, Kruijer W, Vellenga E. 1999. Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-JUN are involved in NFκB-dependent IL-6 expression in human monocytes. J. Immunology 162: 4893.