-
1
-
-
0013675850
-
A repertoire of monoclonal antibodies with human heavy chains from transgenic mice
-
BRÜGGEMANN M., CASKEY H. M., TEALE C., WALDMANN H., WILLIAMS G. T., SURANI M. A. and NEUBERGER M. S. (1989): A repertoire of monoclonal antibodies with human heavy chains from transgenic mice. Proc. Natl. Acad. Sci. USA, 86, 6709-6713.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 6709-6713
-
-
Brüggemann, M.1
Caskey, H.M.2
Teale, C.3
Waldmann, H.4
Williams, G.T.5
Surani, M.A.6
Neuberger, M.S.7
-
2
-
-
0030221606
-
Strategies for expressing human antibody repertoires in transgenic mice
-
BRÜGGEMANN M. and NEUBERGER M. S. (1996): Strategies for expressing human antibody repertoires in transgenic mice. Immunol. Today, 17, 391-397.
-
(1996)
Immunol. Today
, vol.17
, pp. 391-397
-
-
Brüggemann, M.1
Neuberger, M.S.2
-
3
-
-
0025726654
-
Human antibody production in transgenic mice: Expression from 100 kb of the human IgH locus
-
BRÜGGEMANN M., SPICER C., BULUWELA L., ROSEWELL I., BARTON S., SURANI M. A. and RABBITTS T. H. (1991): Human antibody production in transgenic mice: Expression from 100 kb of the human IgH locus. Eur. J. Immunol., 21, 1323-1326.
-
(1991)
Eur. J. Immunol.
, vol.21
, pp. 1323-1326
-
-
Brüggemann, M.1
Spicer, C.2
Buluwela, L.3
Rosewell, I.4
Barton, S.5
Surani, M.A.6
Rabbitts, T.H.7
-
4
-
-
0342437532
-
Production of human antibody repertoires in transgenic mice
-
BRÜGGEMANN M. and TAUSSIG M. J. (1997): Production of human antibody repertoires in transgenic mice. Curr. Opin. Biotechnol., 8, 455-458.
-
(1997)
Curr. Opin. Biotechnol.
, vol.8
, pp. 455-458
-
-
Brüggemann, M.1
Taussig, M.J.2
-
5
-
-
0027263741
-
Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosome
-
CHOI T. K., HOLLENBACH P. W., PEARSON B. E., UEDA R. M., WEDDELL G. N., KURAHARA C. G., WOODHOUSE C. S., KAY R. M. and LORING J. F. (1930): Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosome. Nat. Genet., 4, 117-123.
-
(1930)
Nat. Genet.
, vol.4
, pp. 117-123
-
-
Choi, T.K.1
Hollenbach, P.W.2
Pearson, B.E.3
Ueda, R.M.4
Weddell, G.N.5
Kurahara, C.G.6
Woodhouse, C.S.7
Kay, R.M.8
Loring, J.F.9
-
6
-
-
0027315693
-
Extension of yeast artificial chromosomes by cosmid multimers
-
DAVIES, N. P. and BRÜGGEMANN M. (1993): Extension of yeast artificial chromosomes by cosmid multimers. Nucleic Acids Res., 21, 767-768.
-
(1993)
Nucleic Acids Res.
, vol.21
, pp. 767-768
-
-
Davies, N.P.1
Brüggemann, M.2
-
7
-
-
0039336722
-
Human antibody repertoires in transgenic mice: Manipulation and transfer of YACs
-
McCAFFERTY J., HOOGENBOOM H. R. and CHISWELL D. J. (eds.): IRL, Oxford
-
DAVIES N. P., POPOV A. V., ZOU X. and BRÜGGEMANN M. (1996): Human antibody repertoires in transgenic mice: manipulation and transfer of YACs. In McCAFFERTY J., HOOGENBOOM H. R. and CHISWELL D. J. (eds.): Antibody engineering: a practical approach. IRL, Oxford, 59-76.
-
(1996)
Antibody Engineering: a Practical Approach
, pp. 59-76
-
-
Davies, N.P.1
Popov, A.V.2
Zou, X.3
Brüggemann, M.4
-
8
-
-
14744294865
-
Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin κ locus
-
DAVIES N. P., ROSEWELL I. R., RICHARDSON J. C., COOK G. P., NEUBERGER M. S., BROWNSTEIN B. H., NORRIS M. L. and BRÜGGEMANN M. (1993): Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin κ locus. Biotechnology, 11, 911-914.
-
(1993)
Biotechnology
, vol.11
, pp. 911-914
-
-
Davies, N.P.1
Rosewell, I.R.2
Richardson, J.C.3
Cook, G.P.4
Neuberger, M.S.5
Brownstein, B.H.6
Norris, M.L.7
Brüggemann, M.8
-
9
-
-
8944243547
-
High-avidity human IgK monoclonal antibodies from a novel strain of minilocus transgenic mice
-
FISHWILD D. M., O'DONNELL S. L., BENGOECHEA T., HUDSON D. V., HARDING F., BERNHARD S. L., JONES D., KAY R. M., HIGGINS K. M., SCHRAMM S. R. and LONBERG N. (1996): High-avidity human IgK monoclonal antibodies from a novel strain of minilocus transgenic mice. Nat. Biotechnol., 14, 845-851.
-
(1996)
Nat. Biotechnol.
, vol.14
, pp. 845-851
-
-
Fishwild, D.M.1
O'Donnell, S.L.2
Bengoechea, T.3
Hudson, D.V.4
Harding, F.5
Bernhard, S.L.6
Jones, D.7
Kay, R.M.8
Higgins, K.M.9
Schramm, S.R.10
Lonberg, N.11
-
10
-
-
0020645067
-
Gene transfer into mouse embryos: Production of transgenic mice by pronuclear injection
-
GORDON J. W. and RUDDLE F. H. (1983): Gene transfer into mouse embryos: production of transgenic mice by pronuclear injection. Methods Enzymol., 101, 411-433.
-
(1983)
Methods Enzymol.
, vol.101
, pp. 411-433
-
-
Gordon, J.W.1
Ruddle, F.H.2
-
11
-
-
0027963484
-
Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs
-
GREEN L. L., HARDY M. C., MAYNARD-CURRIE C. E., TSUDA H., LOUIE D. M., MENDEZ M. J., ABDERRAHIM H., NOGUCHI M., SMITH D. H., ZENG Y., DAVID N. E., SASAI H., GARZA D., BRENNER D. G., HALES J. F., MCGUINNESS R. P., CAPON D. J., KLAPHOLZ S. and JAKOBOVITS A. (1994): Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs. Nat. Genet., 7, 13-21.
-
(1994)
Nat. Genet.
, vol.7
, pp. 13-21
-
-
Green, L.L.1
Hardy, M.C.2
Maynard-Currie, C.E.3
Tsuda, H.4
Louie, D.M.5
Mendez, M.J.6
Abderrahim, H.7
Noguchi, M.8
Smith, D.H.9
Zeng, Y.10
David, N.E.11
Sasai, H.12
Garza, D.13
Brenner, D.G.14
Hales, J.F.15
McGuinness, R.P.16
Capon, D.J.17
Klapholz, S.18
Jakobovits, A.19
-
12
-
-
0029551923
-
Production of antigen-specific human antibodies from mice engineered with human heavy and light chain YACs
-
JAKOBOVITS A., GREEN L. L., HARDY M. C., MAYNARD-CURRIE C. E., TSUDA H., LOUIE D. M., MENDEZ M. J., ABDERRAHIM H., NOGUCHI M., SMITH D. H., ZENG Y., DAVID N. E., SASAI H., GARZA D., BRENNER D. G., HALES J. F., MCGUINNES R. P., CAPAON D. J. and KLAPHOLZ S. (1995): Production of antigen-specific human antibodies from mice engineered with human heavy and light chain YACs. Ann. NY Acad. Sci., 764, 525-535.
-
(1995)
Ann. NY Acad. Sci.
, vol.764
, pp. 525-535
-
-
Jakobovits, A.1
Green, L.L.2
Hardy, M.C.3
Maynard-Currie, C.E.4
Tsuda, H.5
Louie, D.M.6
Mendez, M.J.7
Abderrahim, H.8
Noguchi, M.9
Smith, D.H.10
Zeng, Y.11
David, N.E.12
Sasai, H.13
Garza, D.14
Brenner, D.G.15
Hales, J.F.16
McGuinnes, R.P.17
Capaon, D.J.18
Klapholz, S.19
-
13
-
-
0025852445
-
A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
-
KITAMURA D., ROES J., KÜHN R. and RAJEWSKY K. (1991): A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature, 350, 423-426.
-
(1991)
Nature
, vol.350
, pp. 423-426
-
-
Kitamura, D.1
Roes, J.2
Kühn, R.3
Rajewsky, K.4
-
14
-
-
0024845617
-
Construction of mouse A9 clones containing a single human chromosome tagged with neomycin-resistance gene via microcell fusion
-
KOI M., SHIMIZU M., MORITA H., YAMADA H. and OSHIMURA M. (1989): Construction of mouse A9 clones containing a single human chromosome tagged with neomycin-resistance gene via microcell fusion. Jpn. J. Cancer Res., 80, 413-418.
-
(1989)
Jpn. J. Cancer Res.
, vol.80
, pp. 413-418
-
-
Koi, M.1
Shimizu, M.2
Morita, H.3
Yamada, H.4
Oshimura, M.5
-
15
-
-
0028814315
-
Human antibodies from transgenic mice
-
LONBERG N. and HUSZAR D. (1995): Human antibodies from transgenic mice. Int. Rev. Immunol., 13, 65-95.
-
(1995)
Int. Rev. Immunol.
, vol.13
, pp. 65-95
-
-
Lonberg, N.1
Huszar, D.2
-
16
-
-
0028222932
-
Antigen-specific human antibodies from mice comprising four distinct genetic modifications
-
LONBERG N., TAYLOR L. D., HARDING F. A., TROUSTINE M., HIGGINS K. M., SCHRAMM S. R., KUO C.-C., MASHAYEKH R., WYMORE K., MCCABE J. G., MUNOZ-O'REGAN D., O'DONNELL S. L., LAPACHET E. S. G., BENGOECHEA T., FISHWILD D. M., CARMACK C. E., KAY R. M. and HUSZAR D. (1994): Antigen-specific human antibodies from mice comprising four distinct genetic modifications. Nature, 368, 856-859.
-
(1994)
Nature
, vol.368
, pp. 856-859
-
-
Lonberg, N.1
Taylor, L.D.2
Harding, F.A.3
Troustine, M.4
Higgins, K.M.5
Schramm, S.R.6
Kuo, C.-C.7
Mashayekh, R.8
Wymore, K.9
McCabe, J.G.10
Munoz-O'regan, D.11
O'Donnell, S.L.12
Lapachet, E.S.G.13
Bengoechea, T.14
Fishwild, D.M.15
Carmack, C.E.16
Kay, R.M.17
Huszar, D.18
-
17
-
-
0031039315
-
Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice
-
MENDEZ M. J., GREEN L. L, CORVALAN J. R., JIA X.-C., MAYNARD-CURRIE C. E., YANG X.-D., GALLO M. L., LOUIE D. M., LEE D. V., ERICKSON K. L., LUNA J., ROY C. M.-N., ABDERRAHIM H., KIRSCHENBAUM F., NOGUCHI M., SMITH D. H., FUKUSHIMA A., HALES J. F., FINER M. H., DAVIS C. G., ZSEBO K. M. and JAKOBOVITS A. (1997): Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. Nat. Genet., 15, 146-156.
-
(1997)
Nat. Genet.
, vol.15
, pp. 146-156
-
-
Mendez, M.J.1
Green, L.L.2
Corvalan, J.R.3
Jia, X.-C.4
Maynard-Currie, C.E.5
Yang, X.-D.6
Gallo, M.L.7
Louie, D.M.8
Lee, D.V.9
Erickson, K.L.10
Luna, J.11
Roy, C.M.-N.12
Abderrahim, H.13
Kirschenbaum, F.14
Noguchi, M.15
Smith, D.H.16
Fukushima, A.17
Hales, J.F.18
Finer, M.H.19
Davis, C.G.20
Zsebo, K.M.21
Jakobovits, A.22
more..
-
18
-
-
0031555825
-
Mice perform a human repertoire
-
NEUBERGER M. and BRÜGGEMANN M. (1997): Mice perform a human repertoire. Nature, 386, 25-26.
-
(1997)
Nature
, vol.386
, pp. 25-26
-
-
Neuberger, M.1
Brüggemann, M.2
-
19
-
-
0032715903
-
Antibody repertoires of four and five feature translocus mice carrying human immunuglobulin heavy chain and kappa and lambda light chain YACs
-
NICHOLSON I. C., ZOU X., POPOV A. V., COOK G. P., CORPS E. M., HUMPHRIES S., AYLING C., XIAN J., TAUSSIG M. J., NEUBERGER M. S. and BRÜGGEMANN M. (1999): Antibody repertoires of four and five feature translocus mice carrying human immunuglobulin heavy chain and kappa and lambda light chain YACs. J. Immunol., 163, 6898-6906.
-
(1999)
J. Immunol.
, vol.163
, pp. 6898-6906
-
-
Nicholson, I.C.1
Zou, X.2
Popov, A.V.3
Cook, G.P.4
Corps, E.M.5
Humphries, S.6
Ayling, C.7
Xian, J.8
Taussig, M.J.9
Neuberger, M.S.10
Brüggemann, M.11
-
20
-
-
0030600454
-
Assembly and extension of yeast artificial chromosomes to build up a large locus
-
POPOV A. V., BÜTZLER C., FRIPPIAT J.-P., LEFRANC M. P. and BRÜGGEMANN M. (1996): Assembly and extension of yeast artificial chromosomes to build up a large locus. Gene, 177, 195-205.
-
(1996)
Gene
, vol.177
, pp. 195-205
-
-
Popov, A.V.1
Bützler, C.2
Frippiat, J.-P.3
Lefranc, M.P.4
Brüggemann, M.5
-
21
-
-
0033577853
-
A human immunoglobulin λ locus is similarly well expressed in mice and humans
-
POPOV A. V., ZOU X., XIAN J., NICHOLSON I. C. and BRÜGGEMANN M. (1999): A human immunoglobulin λ locus is similarly well expressed in mice and humans. J. Exp. Med., 189, 1611-1620.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1611-1620
-
-
Popov, A.V.1
Zou, X.2
Xian, J.3
Nicholson, I.C.4
Brüggemann, M.5
-
22
-
-
0027451043
-
A method for the generation of YAC transgenic mice by pronuclear microinjection
-
SCHEDL A., LARIN Z., MONTOLIU L., THIES E., KELSEY G., LEHRACH H. and SCHÜTZ G. (1993): A method for the generation of YAC transgenic mice by pronuclear microinjection. Nucleic Acids Res., 21, 4783-4787.
-
(1993)
Nucleic Acids Res.
, vol.21
, pp. 4783-4787
-
-
Schedl, A.1
Larin, Z.2
Montoliu, L.3
Thies, E.4
Kelsey, G.5
Lehrach, H.6
Schütz, G.7
-
23
-
-
0028203509
-
Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM
-
TAYLOR L. D., CARMACK C. E., HUSZAR D., HIGGINS K. M., MASHAYEKH R., SEQUAR G., SCHRAMM S. R., KUO C.-C., O'DONNELL S. L., KAY R. M., WOODHOUSE C. S. and LONBERG N. (1993): Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM. Int. Immunol., 6, 579-591.
-
(1993)
Int. Immunol.
, vol.6
, pp. 579-591
-
-
Taylor, L.D.1
Carmack, C.E.2
Huszar, D.3
Higgins, K.M.4
Mashayekh, R.5
Sequar, G.6
Schramm, S.R.7
Kuo, C.-C.8
O'Donnell, S.L.9
Kay, R.M.10
Woodhouse, C.S.11
Lonberg, N.12
-
24
-
-
0027089852
-
A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins
-
TAYLOR L. D., CARMACK C. E., SCHRAMM S. R., MASHAYEKH R., HIGGINS K. M., KUO C.-C., WOODHOUSE C., KAY R. M. and LONBERG N. (1992): A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins. Nucleic Acids Res., 20, 6287-6295.
-
(1992)
Nucleic Acids Res.
, vol.20
, pp. 6287-6295
-
-
Taylor, L.D.1
Carmack, C.E.2
Schramm, S.R.3
Mashayekh, R.4
Higgins, K.M.5
Kuo, C.-C.6
Woodhouse, C.7
Kay, R.M.8
Lonberg, N.9
-
25
-
-
0034681121
-
Double trans-chromosomic mice: Maintenance of two individual human chromosome fragments containing immunoglobulin heavy and kappa loci and expression of fully human antibodies
-
TOMIZUKA K., SHINOHARA T., YOSHIDA H., UEJIMA H., OHGUMA A., TANAKA S., SATO K., OSHIMURA M. and ISHIDA I. (2000): Double trans-chromosomic mice: Maintenance of two individual human chromosome fragments containing immunoglobulin heavy and kappa loci and expression of fully human antibodies. Proc. Natl. Acad. Sci. USA, 18, 722-727.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.18
, pp. 722-727
-
-
Tomizuka, K.1
Shinohara, T.2
Yoshida, H.3
Uejima, H.4
Ohguma, A.5
Tanaka, S.6
Sato, K.7
Oshimura, M.8
Ishida, I.9
-
26
-
-
0030965015
-
Functional expression and germline transmission of a human chromosome fragment in chimaeric mice
-
TOMIZUKA K., YOSHIDA H., UEJIMA H., KUGOH H., SATO K., OHGUMA A., HAYASAKA M., HANAOKA K., OSHIMURA M. and ISHIDA I. (1997): Functional expression and germline transmission of a human chromosome fragment in chimaeric mice. Nat. Genet., 16, 133-143.
-
(1997)
Nat. Genet.
, vol.16
, pp. 133-143
-
-
Tomizuka, K.1
Yoshida, H.2
Uejima, H.3
Kugoh, H.4
Sato, K.5
Ohguma, A.6
Hayasaka, M.7
Hanaoka, K.8
Oshimura, M.9
Ishida, I.10
-
27
-
-
0030218894
-
Antibody expression from the core region of the human IgH locus reconstructed in transgenic mice using bacteriophage P1 clones
-
WAGNER S. D., GROSS G., COOK G. P., DAVIES S. L. and NEUBERGER M. S. (1996): Antibody expression from the core region of the human IgH locus reconstructed in transgenic mice using bacteriophage P1 clones. Genomics, 35, 405-414.
-
(1996)
Genomics
, vol.35
, pp. 405-414
-
-
Wagner, S.D.1
Gross, G.2
Cook, G.P.3
Davies, S.L.4
Neuberger, M.S.5
-
28
-
-
0028109655
-
The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci
-
WAGNER S. D., POPOV A. V., DAVIES S. L., XIAN J., NEUBERGER M. S. and BRÜGGEMANN M. (1994): The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci. Eur. J. Immunol., 24, 2672-2681.
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 2672-2681
-
-
Wagner, S.D.1
Popov, A.V.2
Davies, S.L.3
Xian, J.4
Neuberger, M.S.5
Brüggemann, M.6
-
29
-
-
0028308322
-
Antibodies generated from human immunoglobulin miniloci in transgenic mice
-
WAGNER S. D., WILLIAMS G. T., LARSON T., NEUBERGER M. S., KITAMURA D., RAJEWSKY K., XIAN J. and BRÜGGEMANN M. (1994): Antibodies generated from human immunoglobulin miniloci in transgenic mice. Nucleic Acids Res., 22, 1389-1393.
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 1389-1393
-
-
Wagner, S.D.1
Williams, G.T.2
Larson, T.3
Neuberger, M.S.4
Kitamura, D.5
Rajewsky, K.6
Xian, J.7
Brüggemann, M.8
-
30
-
-
0031678590
-
Comparison of the performance of a plasmid-based human IgK minilocus and YAC-based human IgK transloci for the production of a human antibody repertoire in transgenic mice
-
XIAN J., ZOU X., POPOV A. V., MUNDT C. A., MILLER N., WILLIAMS G. T., DAVIES S. L., NEUBERGER M. S. and BRÜGGEMANN M. (1998): Comparison of the performance of a plasmid-based human IgK minilocus and YAC-based human IgK transloci for the production of a human antibody repertoire in transgenic mice. Transgenics, 2, 333-343.
-
(1998)
Transgenics
, vol.2
, pp. 333-343
-
-
Xian, J.1
Zou, X.2
Popov, A.V.3
Mundt, C.A.4
Miller, N.5
Williams, G.T.6
Davies, S.L.7
Neuberger, M.S.8
Brüggemann, M.9
-
31
-
-
0029839956
-
Dominant expression of a 1.3 Mb human IgK locus replacing mouse light chain production
-
ZOU X., XIAN J., DAVIES N. P., POPOV A. V. and BRÜGGEMANN M. (1996): Dominant expression of a 1.3 Mb human IgK locus replacing mouse light chain production. FASEB J., 10, 1227-1232.
-
(1996)
FASEB J.
, vol.10
, pp. 1227-1232
-
-
Zou, X.1
Xian, J.2
Davies, N.P.3
Popov, A.V.4
Brüggemann, M.5
|