Comparison of the performance of a plasmid-based human Igκ minilocus and Yac-based human Igκ transloci for the production of human antibody repertoires in transgenic mice

Transgenics

Volumn 2, Issue 3, 1998, Pages 333-343

  Xian, J ^a   Zou, X ^a   Popov, A V ^a   Mundt, C A ^a   Miller, N ^a   Williams, G T ^a   Davies, S L ^a   Neuberger, M S ^a   Bruggemann, M ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Human antibodies; Hypermutation; Locus control; Translocus expression; Variable gene usage; YAC transfer

Indexed keywords

ANTIBODY; DNA; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN;

ANIMAL CELL; ANTIBODY BLOOD LEVEL; ARTICLE; B LYMPHOCYTE; CROSS BREEDING; DOMINANT GENE; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE LOCUS; GENE TARGETING; GENE TRANSLOCATION; HOMOZYGOTE; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; SOMATIC MUTATION; SPLEEN LYMPHOCYTE; TRANSGENIC MOUSE; YEAST ARTIFICIAL CHROMOSOME;

EID: 0031678590     PISSN: 10236171     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)