A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin

Metabolism: Clinical and Experimental

Volumn 52, Issue 5, 2003, Pages 528-534

  Zhou, Yun Ping ^a,b,c   Sreenan, Seamus ^a,b,d   Pan, Chien Yuan ^a,b   Currie, Kevin P M ^a,b   Bindokas, Vytautas P ^a,b   Horikawa, Yukio ^a,b   Lee, Jean Pyo ^a,b   Ostrega, Diane ^a,b   Ahmed, Noreen ^a,b   Baldwin, Aaron C ^a,b   Cox, Nancy J ^a,b   Fox, Aaron P ^a,b   Miller, Richard J ^a,b   Bell, Graeme I ^a,b   Polonsky, Kenneth S ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c Metabolex Inc   (United States)

^d Royal College of Surgeons in Ireland   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOISOCAPROIC ACID; ALOXISTATIN; CALCIUM; CALPAIN; CALPASTATIN; CATHEPSIN B INHIBITOR; GLUCOSE; INSULIN; LACTACYSTIN; N ACETYLLEUCYLLEUCYLMETHIONINAL; N ACETYLLEUCYLLEUCYLNORLEUCINAL; PD 147631; PROTEASOME INHIBITOR; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; [1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER; CALPAIN INHIBITOR III; CYSTEINE PROTEINASE INHIBITOR; DIPEPTIDE; DRUG DERIVATIVE; LEUCINE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; EXOCYTOSIS; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GLUCOSE METABOLISM; INSULIN RELEASE; MITOCHONDRIAL RESPIRATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CELL SEPARATION; DRUG ANTAGONISM; ENERGY METABOLISM; ENZYMOLOGY; IN VITRO STUDY; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION;

ANIMALS; CALCIUM; CALPAIN; CELL SEPARATION; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; ENERGY METABOLISM; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; LEUCINE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NADP; OXIDATION-REDUCTION;

EID: 0038748363     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1053/meta.2003.50091     Document Type: Article

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