Towards new neuroprotective agents: Design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors

Farmaco

Volumn 58, Issue 9, 2003, Pages 851-858

  Pellicciari, Roberto ^a   Camaioni, Emidio ^a   Costantino, Gabriele ^a   Marinozzi, Maura ^a   Macchiarulo, Antonio ^a   Moroni, Flavio ^b   Natalini, Benedetto ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Inhibitors; Ischemia; Neuroprotection; PARP

Indexed keywords

4H THIENO[2,3 C]ISOQUINOLIN 5 ONE; 9 HYDROXY 4H THIENO[2,3 C]ISOQUINOLIN 5 ONE; 9 METHOXY 4H THIENO[2,3 C]ISOQUINOLIN 5 ONE; ADENOSINE DIPHOSPHATE RIBOSE; ISOQUINOLINE DERIVATIVE; NEUROPROTECTIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BRAIN ISCHEMIA; DISEASE COURSE; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; EXPERIMENTAL MODEL; FOLLOW UP; NERVE DEGENERATION; NEUROPROTECTION; STRUCTURE ACTIVITY RELATION;

EID: 0038668581     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(03)00143-5     Document Type: Article

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